Most honoured and thankful for receiving funding from the @erc.europa.eu for the #ERCCoG project BrokenChromosomes! We will investigate how scrambled chromosomes in cancer cells arise to drive aggressive disease @embl.org @ebi.embl.org @sangerinstitute.bsky.social @cancerresearchuk.org

📢 The 2nd European Cancer Dependency Map Symposium is coming! 🗓️ 20 Nov 2025 📍 Human Technopole, Milan Join us for a one-day dive into: 🔹 Cancer genomics 🔹 CRISPR screening 🔹 AI-driven target discovery With the patronage of AIRC 🔗 humantechnopole.it/en/trainings...

Very glad to see this preprint by @lh3lh3.bsky.social and Meyerson labs www.biorxiv.org/content/10.1... confirming our finding of artifactual fold-back inv in long reads (Fig S1 in our @natmethods.nature.com‬ paper presenting SAVANA, which filters such artifacts to improve SV calling 👇

Work by researchers in the group of @isidrolauscher.bsky.social at EMBL-EBI, the R&D lab of @genomicsengland.bsky.social, in collaboration with clinical partners at @ucl.ac.uk, Royal National Orthopaedic Hospital, Instituto de Medicina Molecular João Lobo Antunes, and Boston Children’s Hospital.

Very well done indeed @hbelrick.bsky.social ! 😀

SAVANA is out in the wild 🦁! #SAVANA detects haplotype-resolved somatic structural variants (SVs), copy number aberrations, and calculates tumour purity and ploidy using long-read data. Together with it, a robust, data-driven benchmarking effort! Below is a thread with all the advantages 👇

Thrilled to see #SAVANA out in @natmethods.nature.com 🥳 SAVANA detects haplotype-resolved somatic SVs, copy number aberrations & infers tumour purity & ploidy using long-read sequencing with or WITHOUT a matched germline control 👇https://www.nature.com/articles/s41592-025-02708-0

In this #ToolsoftheTrade article, @timcoorens.bsky.social describes the development of #SComatic, an algorithm enabling the detection of somatic mutations in single cell sequencing data, & its use to study lineage relations + mutational signatures. Read about it here 👇 https://bit.ly/4kyM7...

We have two #postdoc positions open to join my team at @ebi.embl.org in beautiful Cambridge! We are a mission-driven, highly collaborative and dynamic team located at the Wellcome Genome Campus, one of the most exciting hubs in the world focused on biomedical research 👇

Very excited to share the stellar speaker line-up at our ecDNA conference this June in London! 👇 If you're interested in #ecDNA and want to hear or present groundbreaking research, register now. Abstract submission deadline is 14 March. Learn more: www.cancergrandchallenges.org/ecDNA-2025

🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social doi.org/10.1158/2159...