Out today: Molecular Residual Disease Precedes Disease-Free Survival Events by Months, a #ResearchWatch summary of an impactful exploratory post hoc analysis of the ADAURA trial by Dr. Roy Herbst, Dr. Thomas John, Dr. Yi-Long Wu, and colleagues aacrjournals.org/cdnews/news/...

ICYMI: Ascites-derived Lipid Uptake Drives NK Cell Dysfunction in Ovarian Cancer, a #ResearchWatch summary of a new study by @karen--s.bsky.social, @lydialynch.bsky.social, and colleagues at @ludwigcancer.bsky.social @princetonmolbio.bsky.social aacrjournals.org/cdnews/news/...

ICYMI: SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity, a #ResearchWatch summary of a new study by Dr. Bo Li, @liliyanglab.bsky.social, and colleagues at @dgsomucla.bsky.social @uclastemcell.bsky.social aacrjournals.org/cdnews/news/...

Out today: Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer, a #ResearchWatch summary of a new study by Dr. Gilles Rademaker, @rushika-perera.bsky.social, and colleagues at @ucsanfrancisco.bsky.social 🧬 aacrjournals.org/cdnews/news/...

ICYMI: "Patient-Specific Hematologic Setpoints Inform Diagnosis and Prognosis" - a #ResearchWatch summary of a study by Brody Foy, John M. Higgins, and colleagues @uwdeptmedicine.bsky.social @harvardmed.bsky.social #MassGeneralBrigham doi.org/10.1158/2159...

Cancer Discovery #ResearchWatch: Digoxin Reduces Circulating Tumor Cell Cluster Size in #BreastCancer, a summary of the study by Christian Kurzeder, Bich Doan Nguyen-Sträuli, Ilona Krol, Alexander Ring, Marcus Vetter, Nicola Aceto, et al @ethzurich.bsky.social @unibas.ch doi.org/10.1158/2159...

ICYMI: "Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours" - a #ResearchWatch summary of a study by Ignacio Melero, Eugen Leo, and colleagues #ClinicaNavarra #CIMA_unav #visugromab #CatalYm doi.org/10.1158/2159...

🧪Read this week's Cancer Discovery #ResearchWatch: The Immune Evasin Nef Augments Allogeneic #CART Function and Survival, a summary of the study by Karlo Perica, Michel Sadelain, and colleagues @mskcancercenter.bsky.social @mskdeptofmed.bsky.social doi.org/10.1158/2159...

🧪Read today's #ResearchWatch: A Pediatric Pan-Cancer Cohort Enables the Study of Systemic Antitumor Immunity, a summary of a 📃by Qi Chen, Binbin Zhao, Ziyang Tan, Linda Ljungblad, @petterbrodin.bsky.social, et al @imperialcollegeldn.bsky.social @ki.se aacrjournals.org/cdnews/news/...

Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬

Read this week's Cancer Discovery #ResearchWatch: Cancer Cells Induce T-Cell Dysfunction Through Mitochondrial Transfer, a summary of the study by Hideki Ikeda, Yosuke Togashi, and colleagues at Okayama University doi.org/10.1158/2159...

🧬 #ResearchWatch: Loss–Translocation–Amplification #Chromothripsis Drives #Osteosarcoma Evolution, a summary of the study by @jevalleinclan.bsky.social, Solange De Noon, Adrienne Flanagan, Isidro Cortes-Ciriano, and colleagues @ucl.ac.uk @ebi.embl.org @uclnews.bsky.social doi.org/10.1158/2159...

Cancer Discovery #ResearchWatch: High-risk ER+ #BreastCancers Genomically Resemble HER2+ Tumors, a summary of the study by @khoulahan.bsky.social, @lisemangiante.bsky.social, @crissotomayor.bsky.social, @alvinahere.bsky.social, @cncurtis.bsky.social + colleagues @ Stanford doi.org/10.1158/2159...

Congratulations on these exciting results, Nick and team! We were very happy to feature the work! #ResearchWatch

San Diego morning fog forced a flight diversion to Vegas… but finally made it! Very excited to be here at #ASH24!

How do barrier tissues promote repair and regeneration without tipping the ⚖️ toward malignant transformation? Find out in today's #ResearchWatch summary of a recent 📜 by Srustidhar Das, S. Martina Parigi, Xinxin Luo, Eduardo J. Villablanca, and colleagues. aacrjournals.org/cdnews/news/...

Out today: Oncolytic Virotherapy Plus Nivolumab Is Safe in Muscle-Invasive #BladderCancer, a #ResearchWatch summary of recent clinical findings by Roger Li, James J. Mulé, Jose R. Conejo-Garcia, and colleagues. aacrjournals.org/cdnews/news/...

Countdown to #ASH24! Are you heading to San Diego this weekend? If so, I'd love to connect! If you're presenting, please let me know - I want to hear about your work!

Last week in Cancer Discovery News: GD2-CAR T-cell Therapy is Safe in H3K27M+ Diffuse Midline Glioma, a #ResearchWatch summary of promising clinical findings by Michelle Monje, Sneha Ramakrishna, Crystal Mackall, and colleagues. doi.org/10.1158/2159...

ICYMI: "APOBEC3-Mediated Mutations Promote CCND1 ecDNA Biogenesis in Bladder Cancer," a #ResearchWatch summary of recent findings by Duy D. Nguyen, William F. Hooper, Weisi Liu, Olivier Elemento, @nicorobine.bsky.social, Bishoy M. Faltas, and colleagues. doi.org/10.1158/2159...

ICYMI: "Epigenetic Regulation of T-Cell Differentiation Mediates Immunotherapy Response," a #ResearchWatch summary of recent findings from Tae Gun Kang, Ben Youngblood, Caitlin Zebley, and colleagues. doi.org/10.1158/2159...

Hello, hello! Very happy to see so many familiar faces over yonder. I’m excited to continue connecting and to receive my daily dose of excellent science! 🤗🔬🧬

Follow Cancer Discovery News for breaking updates and Research Watch summaries! Visit the homepage aacrjournals.org/cdnews and sign up for email alerts aacrjournals.org/pages/alerts!