Do all #NTFs regulate #MotorNeuron axonal transport in vivo? Our new preprint shows they do not. #BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect. #AxonalTransport regulation is selective, not universal. @jamessleigh.bsky.social @uclqsion.bsky.social

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org www.science.org/doi/10.1126/...

How much of what we think we ‘know’ is just trust in the person that told us? And what price do we pay for confusing the two? Coming soon in Science Without Anguish: ‘Don’t believe everything you think!’ sciencewithoutanguish.com Starts Monday 22nd Sep

Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes: www.biorxiv.org/content/10.1... @uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

It's an honour to become a Professor at such a wonderful institution @uclqsion.bsky.social @uclbrainscience.bsky.social. The @uclqsneuromuscular.bsky.social is an amazing place to work and I couldn't have done it without my fantastic team, mentors and collaborators: www.ucl.ac.uk/brain-scienc...

🚨 New #ALS #MND publication from our lab (co-lead @drchayts.bsky.social), in collaboration with Bernát Nógrádi and colleagues from Hungary and Sonia Alonso-Martin and colleagues from Spain, just published in @natcomms.nature.com -> rdcu.be/eyNIs

Next UCL ALS-FTD Network Seminars - 25 July at 4pm, Gilliatt LT, QSH. 'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs' 'Generation of a universal human cellular platform for drug testing in ALS' 'A forebrain organoid model of progranulin-associated FTD'

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal doi.org/10.1101/2025...

Delighted that the department has been awarded Gold for Laboratory Efficiency Assessment Framework (LEAF) 2025. We were commended on the labs signage, management and sustainable initiatives across the whole department.

#ResearchResources: Lots of great free resources for researchers & research students. Thesis planners, goal setting tools, agendas, To-Do lists. Completely customisible and free. No login, no catches. Just download & use. From: buff.ly/2L0YISj #PhDchat #ECRchat #postdoc

We welcome Volume 247 with this fantastic image from work by Sosa et al. This study provides the first comprehensive description of the hindlimb musculature of the #Emperor #Penguin (Aptenodytes forsteri) across different ontogenetic stages. doi.org/10.1111/joa....

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model! www.biorxiv.org/content/10.1... @uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_... #Neuroscience #Postdoc #ResearchOpportunity

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

Registration is now open for NeuroBioUK 2025! This year we're looking forward to hearing from our plenary speaker @cathyabbott.bsky.social. As ever, all other talks chosen from submitted abstracts so get submitting - we can't wait to see you there! neurobiouk.sites.sheffield.ac.uk/registration

Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.sciencedirect.com/science/arti... @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging

We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25. The theme is Translating Targets to Therapies. To register, click below⬇️ www.eventbrite.co.uk/e/ucl-queen-...

The last part of our SMA genetics trilogy is now online at iScience @cellpress.bsky.social! Here we use ONT technology to determine SMN2-specific methylation profiles. We find how methylation may regulate SMN with aging but it may not be a great biomarker. Have a look: www.cell.com/iscience/ful...

If you're struggling to visualise mouse NMJs, we've got a protocol just for you! bio-protocol.org/en/bpdetail?... Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬

The longer we have worked on and refined this #microtubule - based model of #neurodegeneration, the more convincing it becomes. It is the fruit of 20 years of work. If you are interested, join my THE CYTOSKELETON OF NEURONS AND GLIA online talk this Thurday: ncytoskeleton.wixsite.com/webinars

A 🧵 to walk those interested through this paper...

Finally! (remember the famous 2022 ASCB poster and Twitter discussion) www.biorxiv.org/content/10.1...

🧬✨ Get ready for the UCL Neuroscience Symposium 2025! Join us to explore groundbreaking research and connect with over 600 neuroscientists. Book your place now:

Yet another very proud supervisor moment - congratulations to Qiuhan Lang for passing her viva with flying colours today! Thank you very much to examiners @tomgillingwater.bsky.social and Tom Cunningham

Very proud of team member Dr. Ellie Rhymes for coming Highly Commended in MDUK's Early Career Scientist of the Year Award: www.musculardystrophyuk.org/news/preside... @mdukcharity.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social

‘Travel agencies charge far more than it would cost an academic to arrange their own travel and accommodations - sometimes staggeringly more.’

Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September! neurobiouk.sites.sheffield.ac.uk

Join us for the next talk in the UCL Neurology Society x Queen Square Lecture Series! 4th March 2025, 5.30pm Featuring Dr. Oliver Ziff, a neurologist and NIHR Clinical Lecturer at UCL, specialising in neuromuscular diseases. app.medall.org/event-listin...

For Rare Disease Day, check out this great podcast on changing the future of muscle wasting conditions. Featuring my Queen Square colleague Dr Jasper Morrow, Dr Kate Adcock and Tahira Mathur of Muscular Dystrophy UK www.optimumcomms.com/podcast/#epi...

Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin @ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding. www.pnas.org/doi/10.1073/...

First peer reviewed article from our lab is now out. If you are new to stress granule field, you will find this manuscript helpful. Big shout out to @Meghal Desai @keyagulati @Manasi Agrawal, @Shruti Ghumra Thanks @MerkinPnnrCtr for funding 🙏🏼 journals.lww.com/nrronline/ab...

I've been a bit slow to post about this, but our work on RBL2-linked disease is now available online in #Brain. We provide a comprehensive characterisation of clinical phenotypes, and explore the neurological function of the #Drosophila orthologue, Rbf. (1/2) doi.org/10.1093/brai...

FYI: we will be hosting the inaugural UCL Dystonia Day, on May 14th! This Symposium will showcase the latest research into defining dystonia patho-mechanisms and identifying novel treatments for this debilitating disease. www.ucl.ac.uk/ion/events/2...

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging

Here is a starter pack of Academics, Clinical Academics and research groups at Queen Square's UCL Institute of Neurology and/or the National Hospital for Neurology and Neurosurgery go.bsky.app/BTjbEAw

The 2025 UCL Neuroscience Symposium is now open for registrations! ✅ Join us on Wednesday 18 June 2025 to hear talks from leading neuroscientists on the cutting-edge research at UCL and beyond. Connect with the community and save the date by registering today! www.eventbrite.co.uk/e/ucl-neuros...

We're excited to join BlueSky! Make sure to follow us for the latest news from the UCL Queen Square Institute of Neurology.

I'm glad to share that we are back with the #NGFWebinarSeries on 2025. Join us every second Thursday of the month, starting with Prof. Brian Pierchala on 9th Jan, who will be opening the new season. More info & registration? ngfwebinarseries.org

Short perspective from Dr. Ellie Rhymes on shared mechanisms and phenotypes in ARS-related neuropathies: journals.lww.com/nrronline/ci... #CMT #neuropathy #PeripheralNerve

A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...

👋Hi new followers! 👋 At @JournalofAnat, we seek to advance the understanding of all aspects of human and comparative anatomy through the analysis of structure, function, development, and evolution. More about us, and submit your papers here: onlinelibrary.wiley.com/journal/1469...

First post on BlueSky! Stellar post-doc from the lab @gabrielaughey.bsky.social will be giving a Development Node webinar next week 🙂, describing his work using Drosophila to probe cell-cycle dysregulation in neurodevelopmental disease. Please tune in! thenode.biologists.com/development-...

Research Culture starter pack. Certainly incomplete. Please give me a nudge to add more! go.bsky.app/PyBGpg8

By popular demand: the Axon Degeneration starter pack. Definitely incomplete so let me know who I missed. go.bsky.app/5BH6mBE