Gabriel Aughey
@gabrielaughey.bsky.social
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Neurobiologist at UCL. Interested in neurological disease, genetics, behaviour, and development.
Always shocking to see these kinds of data collected together. "[publishers made]US$12 billion in profits between 2019 and 2024" - That's $12 billion diverted away from actual research or materially supporting the community - these are disgusting numbers.
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9 days ago
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Really confused about what problem LLMs like qed are meant to be solving? Is it meant to be for people writing papers - in which case we already have well established mechanisms for feedback (i.e. speaking with human colleagues), or for reviewers - obviously problematic for so many reasons!?
9 days ago
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Alejandro Montenegro
about 1 month ago
PREACH!
www.nature.com/articles/s41...
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Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology
As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.
https://www.nature.com/articles/s41556-025-01754-2
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Gabriel Aughey
FlyBase
6 months ago
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
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Andreas Prokop
6 months ago
SUSTAINABILITY &
#DROSOPHILA
- If you keep flies & have tried to re-use containers but then given up on it, please could you let us know & tell us the reasons? We urgently need statements for a publication about sustainability in fly labs. Please, contact
[email protected]
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Mark A. Hanson
6 months ago
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using
@flybase.bsky.social
please donate using the link in post below. This incredible community, on whose backs our
#Drosophila
labs depend, can't be left out to dry.
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Tony Southall
7 months ago
New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis.
tinyurl.com/s44s2z95
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Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation
The RNA-binding protein Sex-lethal (Sxl) is classically known as a master regulator of sex determination and mRNA splicing in Drosophila melanogaster. However, this role is not conserved across specie...
https://tinyurl.com/s44s2z95
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Surfin' NuRD
7 months ago
Pedestrians killed by car drivers in UK annually: >400 Cyclists killed by car drivers in UK annually: >100 Pedestrians killed by cyclists in UK annually: <3 So which of these is the most scary and worthy of more laws?
www.theguardian.com/news/2025/ap...
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Cyclists who kill pedestrians could be jailed for life under new law in England and Wales
Reckless cycling is currently prosecuted under legislation from the 1860s, with a maximum two-year jail sentence
https://www.theguardian.com/news/2025/apr/24/death-by-dangerous-cycling-crime-policing-bill
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Royal Entomological Society
8 months ago
🔔 Reminder: RES
#InsectWelfare
Survey 🦗 We’re gathering perspectives on the ethical treatment of insects in research. If you’re in
#InsectResearch
, your voice is essential! Deadline: 1 April 🔽
buff.ly/kEmqgdr
#EthicsInScience
#InsectEthics
#AnimalResearch
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Gabriel Aughey
Maya Voichek
8 months ago
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
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Masud Husain
9 months ago
Why academia is sleepwalking into self-destruction. My editorial
@brain1878.bsky.social
If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
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Mike Feigin 🥯
9 months ago
I had that nightmare again. The one where I’m a postdoc.
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John Ganz
9 months ago
To me, a Nazi salute means, "I want to murder your family." There can be no irony about it: It puts deep anger and hatred in my heart to see it done and I will never forgive anyone who justifies or minimizes it.
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I've been a bit slow to post about this, but our work on RBL2-linked disease is now available online in
#Brain
. We provide a comprehensive characterisation of clinical phenotypes, and explore the neurological function of the
#Drosophila
orthologue, Rbf. (1/2)
doi.org/10.1093/brai...
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Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder
RBL2 dysfunction, which disrupts cell-cycle gene expression, has been linked to a severe neurodevelopmental disorder. Aughey et al. characterize a cohort o
https://doi.org/10.1093/brain/awae363
9 months ago
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Gabriel Aughey
Abigail Wilson, PhD
10 months ago
Delighted to have been selected to give a talk on 3rd March at the 4th Crick Rare Diseases Conference
@crick.ac.uk
- there's still time to register (and free to register for students!)
www.crick.ac.uk/whats-on/4th...
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4th Crick Rare Diseases Conference
https://www.crick.ac.uk/whats-on/4th-crick-rare-diseases-conference?dm_i=7I3X,8B7R,27AKNZ,10YOM,1
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Auke-Florian 🪹
10 months ago
Bird nests made from anti-bird spikes?! 🤯 Hi, I'm a nest researcher 👋 and new here on BlueSky, sharing the craziest
#bird
nests I've ever found. 👀 Today, I’m sharing my discovery of rebellious birds that build nests out of anti-bird spikes. And honestly, it's like telling a joke... A thread. 🧵
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Was wondering what had been going on. Please stop this - flybase is my emotional support database - I need to visit several times just to get through the day!
add a skeleton here at some point
10 months ago
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Annika Barber
10 months ago
If anyone happens to need it this week for...reasons...this is the best graphic on the complexity of human sex determination I've ever seen. I use it in an undergrad course on gene regulatory mechanisms. Shoutout to
@unamandita.bsky.social
!
www.scientificamerican.com/article/beyo...
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Beyond XX and XY: The Extraordinary Complexity of Sex Determination
A host of factors figure into whether someone is female, male or somewhere in between
https://www.scientificamerican.com/article/beyond-xx-and-xy-the-extraordinary-complexity-of-sex-determination/
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Loïc A. Royer 💻🔬🧪
11 months ago
The birth of fruit fly's central nervous system imaged with multicolor
#adaptive
#lightsheet
microscopy. The microscope self-aligns to a signal that appears during imaging.
www.nature.com/articles/nbt...
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Amoyel lab
12 months ago
We're hiring a postdoc! Please forward to people you know who are looking for positions. Interested in studying how metabolism is wired to support fertility? 🔬🪰 Come join us! Ad to go live next week, but informal enquiries encouraged.
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Fillip Port
12 months ago
Our new preprint is out - please share! We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals. Grab a ☕ and let’s dive in. 🧵🧪 1/n
#CRISPR
#geneediting
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Micah G. Allen
12 months ago
Would you like to see
@biorxivpreprint.bsky.social
add a share to blue sky button?! I know I would! Share this post to let
@richardsever.bsky.social
@erictopol.bsky.social
and others at bioarxiv know!
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Moita Lab
12 months ago
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (
www.biorxiv.org/content/10.1...
). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
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A (lightly) paraphrased sample of recent feedback from a failed fellowship application: Strength - The project was important and ambitious. Weakness - While the project was interesting and important, it was too ambitious to fund. ...not really sure what to take from this experience!🤔
12 months ago
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Gabriel Aughey
the Node
12 months ago
Register for the final Development presents... webinar of 2024, chaired by
@dev-journal.bsky.social
Senior Editor
@amjeve.bsky.social
. We'll hear from Madalena Reimão Pinto and
@gabrielaughey.bsky.social
on the topic of
#GeneRegulation
in
#DevBio
📆Wed 4 Dec 15:00GMT
us02web.zoom.us/webinar/regi...
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Gabriel Aughey
The Company of Biologists
12 months ago
🧪The final Development presents... webinar of 2024 will be chaired by Development’s Senior Editor
@amjeve.bsky.social
. We will hear from Madalena M. Reimão Pinto and Gabriel Aughey on the topic of gene regulation.
#DevBio
#GeneRegulation
📆Wed 4 Dec 15:00GMT Register here:
bit.ly/3OpUfu2
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I'm a bit sceptical about joining another social network, but honestly it's a bit quiet over on mastodon. So I'm tentatively dipping into Bluesky, hoping to engage with like-minded neuro, genetics, and Drosophila community. It's nice to see so many people here already!
12 months ago
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