Read this exciting work from the @kristywelshhans.bsky.social lab led by Manasi Agrawal. Very happy to have contributed to this story. Restoring DSCAM expression mitigates neuronal morphology and axon guidance deficits in Down syndrome academic.oup.com/brain/articl...

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

First major grant for the lab. Thank you, #NJCBIR, for believing in us. Now let's get back to the bench to get that work done :)

🚨 New pre-print! If you are interested in new roles for SARM1, check this out. The lab did cool work showing macrophages need Sarm1 to efficiently respond to immunoogical stimuli and PNS injury. Cell specific sarm1 KO mice give surprising results- check it out! www.biorxiv.org/content/10.6...

🧪 When an mRNA has not one or two, but at least THREE localization signals, suggesting that mTOR mRNA requires robust localization. See our preprint, lead by Nitzan Samra with greatly appreciated collaborations with @sahoolab.bsky.social and the Jeffery L. Twiss lab www.biorxiv.org/content/10.6...

How many axon localization elements are in one mRNA? mTor mRNA seems to have at least 3. Read this interesting preprint from the @mfainzilber.bsky.social lab. Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth www.biorxiv.org/content/10.6...

There is a current push towards doing biological research using only hiPSC models, but are we there yet? Manasi nicely discusses it in this review using neural repair as a model system. www.sciencedirect.com/science/arti...

So it was an RNA world 🤔 A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/...

Very happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth. We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory! www.science.org/doi/10.1126/...

🧪 An EMBO Meeting on Axon Biology in Okinawa, Japan Iconic science at an amazing venue. Please join us! EMBO | COB Workshop on Axonal degeneration and regeneration meetings.embo.org/event/26-axo...

Very exciting results from the Fanzilber lab!

ATP - not only a fuel source! Intriguing work from Marco Terenzio and colleagues at the OIST www.science.org/doi/full/10....

Excellent story from the Woolf lab! www.nature.com/articles/s41...

Pretty cool!

New preprint from Roz Segal’s group on specialization in local axonal translation www.biorxiv.org/content/10.1...

Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin @ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding. www.pnas.org/doi/10.1073/...

First peer reviewed article from our lab is now out. If you are new to stress granule field, you will find this manuscript helpful. Big shout out to @Meghal Desai @keyagulati @Manasi Agrawal, @Shruti Ghumra Thanks @MerkinPnnrCtr for funding 🙏🏼 journals.lww.com/nrronline/ab...

New study from the Twiss lab! www.biorxiv.org/content/10.1...

Synthetic biomolecular condensates enhance translation from a target mRNA in living cells www.nature.com/articles/s41...

G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration: Cell Reports www.cell.com/cell-reports...

Molecular determinants of condensate composition: Molecular Cell www.cell.com/molecular-ce...