Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...

We have a postdoctoral position available in the lab europeandrosophilasociety.org/job/postdoct.... Get in touch if interested!

1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇

Our BBSRC CircadiAgeing sLola project launches today with @hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing circadiageing.blogs.bristol.ac.uk

The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues. circadiageing.blogs.bristol.ac.uk

VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.

Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.sciencedirect.com/science/arti... @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging

The brain’s energy landscape as a potential window into brain health www.nature.com/articles/d41... (study led by Martin Picard and Michel Thiebaut de Schotten)

Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence https://www.biorxiv.org/content/10.1101/2025.03.31.646469v1

www.nature.com/articles/s41... Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease www.nature.com/articles/s41...

Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 #FluorescenceFriday Imaged by @batemanlab.bsky.social

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites www.nature.com/articles/s41...

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

imAGEin: one-in-a-kind 2Y Erasmus Mundus Joint Master @euerasmusplus.bsky.social on the Biology of #ageing. shorturl.at/n4jsd Partners: @ucoimbra.bsky.social @sorbonne-universite.fr @univcotedazur.bsky.social @unisevilla.bsky.social @unicologne.bsky.social. 15 scholarships available to cover costs.

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice: www.biorxiv.org/content/10.1... Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al. @uclqsion.bsky.social #aging

Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

www.theguardian.com/society/2024... Good use of hospital records, biobank data, and AI

Announcing award of our 5 year BBSRC sLola CircadiAgeing: clock excitability, circadian rhythms & healthy ageing grant with @hughp.bsky.social @MeganGJackson @mbra3.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @alessiovagnoni.bsky.social Edgar Buhl bristol.ac.uk/news/2024/de...

Really excited to be part of the CircadiAgeing team @docfly.bsky.social @mbra3.bsky.social @krasimiratsaneva.bsky.social, H.Piggins, M.Belle @official-uom.bsky.social

Excited to be part of one of the BBSRC larger and longer grants with such a great team. Healthy circadian aging is healthy brain aging… @imperialmed.bsky.social www.ukri.org/news/bbsrc-i...

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...

Ye Olde endosymbiont never cease to surprise rdcu.be/d222K

There is an open PhD position in our Lab! In collaboration with the lab of @manuperisse.bsky.social we will study how flies evaluate negative experiences based on context. More info here: mrtlllab.uni-mainz.de/we-are-hiring/

High-pressure freezing EM and modelling to study membrane 'nanopearling' vs 'beading' in unmyelinated axons of the mouse brain www.nature.com/articles/s41...

The 7th edition is in place!. It wil be held in Marbella, Chile next year and will be again part of the EMBO workshop series. The organizers are @monicamsousa.bsky.social, Kassandra Ori-Mckenney and Tomas Falzone. Registration is already opened neurocytoskeleton.com/2025/

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

‘Change becomes inevitable when the right platform meets enough willing users’. It sounds like a great starting point @colemanlab.bsky.social colemanlab.brc.cam.ac.uk/blog/peer-re...

Opportunities to join us as a junior group leader. #Genetics As well as the advert, there's more general background, testimonials, etc., on our web page: www.gen.cam.ac.uk/join-us/grou...

Hello Bluesky! I came over from the other platform and slowly building up. Nice to re-connect with many familiar faces and with new ones.