Our next welfare webinar will focus on using positive reinforcement techniques to improve the welfare of pigs and dogs in research by encouraging voluntary cooperation with procedures and reducing stress. 📅 Thursday 27 November, 12.30 – 13.30 (GMT) 👉 Register: nc3rs.org.uk/events/welfa...

New publication: Home-cage monitoring to refine and reduce animal use in drug safety testing A cross-sector collaboration demonstrates that non-invasive, continuous monitoring of rodent behaviour improves detection of central nervous system side effects for new drugs. 👉 nc3rs.org.uk/news/home-ca...

⏳ Pyrogenicity testing survey closing on Thursday 7 November. Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing. Take the survey: nc3rs.org.uk/our-portfoli...

@inserm.fr have reached approaching 1,000 researchers with a training course that uses the NC3Rs Experimental Design Assistant (EDA) to teach best practice for experimental design of in vivo studies. Learn more in our interview with the organiser behind Parcours-EDA: nc3rs.org.uk/news/experim...

Our Chief Executive Vicky Robinson provided comment on the statistics of scientific procedures on animals carried out in Great Britain in 2024, released today. Read the report from the Home Office: www.gov.uk/government/s...

NC3Rs staff have co-authored a new chapter in the fourth edition of the IACUC Handbook to support ethical review bodies assess the reliability of animal research. It includes practical support to avoid animals being wasted in studies that produce unreliable results: nc3rs.org.uk/news/conside...

⏳ NC3Rs-BBSRC Business Interaction Vouchers application deadline approaching: 16.00, Tuesday 4 November. Apply for up to £25k to support industry-academic collaborations that advance 3Rs approaches in oncology, cardiovascular science and new approach methodologies: nc3rs.org.uk/our-funding-...

A new imaging system developed through our Transgene Track CRACK IT Challenge enables real-time, non-invasive monitoring of gene and cell therapies in rodents – reducing animal use and improving data quality in preclinical studies. Learn more: nc3rs.org.uk/crackit/news...

Our latest report highlights the outcomes of the first UK funding call for infrastructure to support animal replacement methods. We made 11 awards (£3.95M) to establish national facilities and provide training opportunities across the UK: nc3rs.org.uk/news/investi...

Thanks to the 320 attendees from 30 countries who joined us over two webinar sessions that explored model-specific refinements and practical tools to minimise laboratory animal suffering. If you missed the session the recording is now available. 👉 nc3rs.org.uk/3rs-resource...

NEW SURVEY. Do you manufacture, regulate or produce biological therapeutics? Help the NC3Rs shape the future of non-animal pyrogenicity testing of biologics: nc3rs.org.uk/our-portfoli...

Register now for an afternoon of networking and expert insights at an event that brings together researchers, clinicians and neurosurgeons to discuss the practicalities and potential of using human brain tissue to replace animal models in neuroscience.

Join researchers, clinicians and neurosurgeons for an afternoon of expert insights and networking to discuss the practicalities and potential of using human brain tissue to replace animal models in neuroscience. 📅 Friday 7 November, 13.00 – 16.00 📍 UCL, London Register: nc3rs.org.uk/events/using...

Recordings available: nc3rs.org.uk/crackit/tech... Watch presentations from six model developers to learn more about their technologies and explore new partnerships to access 3Rs approaches for your oncology research.

We were delighted to welcome 12 BBSRC-funded PhD students to our annual summer school this year alongside NC3Rs-funded students. Our training for early career researchers focuses on their role as ambassadors for the 3Rs throughout their PhD and beyond. 💡 Read more: nc3rs.org.uk/news/trainin...

Please note that our Experimental Design Assistant (EDA) eda.nc3rs.org.uk will be offline tomorrow from 4pm (BST) for planned maintenance. Full details 👇.

Are you a researcher, developer, or industry/regulatory user of NAMs? Join our webinar with @brittoxsoc.bsky.social on how AI can improve safety assessment and reduce reliance on animals: nc3rs.org.uk/events/artif... ⏰ Registration closes: 24 September, 14.00 📅 Webinar: 25 September, 14.00 – 16.00

New report from the NC3Rs, in collaboration with @abpi.bsky.social and MHRA, explores how New Approach Methodologies (NAMs) can transform the way new medicines are developed, harnessing cutting edge human relevant technologies and reducing reliance on animal testing. nc3rs.org.uk/news/incorpo...

Final week to register! Join us at our next Technology Partn3Ring webinar to collaborate with academics and SMEs developing the latest 3Rs technologies in cancer research: nc3rs.org.uk/events/techn... ⏰Registration closes: Tuesday 23 September, 14.00 📅 Webinar: Wednesday 24 September, 14.00 – 15.15

Join us next week to learn more about misconceptions around sex-inclusive research and how the Sex Inclusive Research Framework can be used by scientists, ethical review bodies and funders: nc3rs.org.uk/events/tackl... 📅 18 September, 15.00 – 16.00 📜 One hour of continuing professional development

Online conference: Dosing in animal models of neuroscience @britpharmsoc.bsky.social ‬and @britishneuro.bsky.social ‬are hosting an online conference to explore 3Rs opportunities in preclinical dosing practices for neuropharmacology research. 📅 23 Sept, 9.30 – 16.15 👉 nc3rs.org.uk/events/dosin...

Teach others how to use the EDA to design rigorous in vivo experiments that use the minimum number of animals: nc3rs.org.uk/events/ukrn-... ⏳ Registration closing soon: Wednesday 17 September 🤝Delivered by @drejpearl.bsky.social and @ukrepro.bsky.social 📅 Thursday 13 November, 10.00 – 16.00 (GMT)

Congratulations to Dr Renata Nundes for winning the EUSAAT poster award at WC13! It is fantastic to see further global recognition of her in vitro assay to replace mice in snake antivenom potency testing, which was highly commended in this years’ International 3Rs Prize: nc3rs.org.uk/news/3rs-pri...

Are you interested in the latest 3Rs technologies in oncology research? Join us at our next Technology Partn3Ring webinar for opportunities to collaborate and access new 3Rs models. 📅 Wednesday 24 September, 14.00 – 15.15 (BST) 👉 Register now: nc3rs.org.uk/events/techn...

We are supporting in-person training workshops to promote the use of skin swabbing as a refined approach for genotyping zebrafish. 🐟 Suitable for technical staff and researchers 🤝 Personalised support in small groups 📍 Delivered at your facility (UK only) Find out more: nc3rs.org.uk/training-wor...

Register now for two upcoming sessions on minimising animal suffering with early interventions and refined humane endpoints. 📅 11 and 16 September, 12.30 – 13.30 🙋🏻‍ For animal technicians, ethics committee members and researchers 📜 Certificates of attendance available 👉 nc3rs.org.uk/welfare-webi...

If you are attending WC13, make sure you connect with @james-barker.bsky.social and @drejpearl.bsky.social from our Experimental Design and Reporting team to learn more about resources to embed the 3Rs in the planning and publication of research. 📝 Find out more: nc3rs.org.uk/events/world...

Webinar: Future perspectives on artificial intelligence in safety assessment Three leading experts will discuss how AI and approaches such as machine learning can be used to improve toxicity prediction and reduce the reliance on animal models. 📅 25 September, 14.00 👉 nc3rs.org.uk/events/artif...

⏳ Registration closing on Thursday 28 August! Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative. Find out more: nc3rs.org.uk/events/nc3rs...

The next webinar in our welfare series will focus on refined humane endpoints and early interventions. Join us next month, across two lunchtime sessions, with expert speakers from academia and industry. 📅 Part 1: Thursday 11 September. 📅 Part 2: Tuesday 16 September. 👉 nc3rs.org.uk/welfare-webi...

Thank you to the 100+ people from 24 countries who joined us at our 20th International 3Rs Prize ceremony to hear about work to replace animal-derived antibodies and in vivo antivenom tests, and to GSK who have sponsored the Prize from the start. Watch the recording: nc3rs.org.uk/news/3rs-pri...

Webinar recording and Q&A available: Improving the lives of laboratory zebrafish Professor Robert Gerlai explores how optimising housing and handling improves zebrafish welfare and research quality. 👉 nc3rs.org.uk/3rs-resource-library/welfare-webinar-improving-lives-laboratory-zebrafish

Looking for support to teach experimental design? Join our online workshop with @ukrepro.bsky.social on using the Experimental Design Assistant (EDA) to plan rigorous, reproducible animal studies. 📅 13 November, 10.00 – 16.00 (GMT) ❗ Registration closes: 17 September 👉 nc3rs.org.uk/events/ukrn-...

Are you attending the 20th International Xenopus Conference in August? 🐸 Esther Pearl (@drejpearl.bsky.social) will be sharing our work and resources relevant to research involving Xenopus, including improving experimental design and refining husbandry practices: nc3rs.org.uk/events/20th-...

Excited to send biological models trump cards from the NC3Rs office for the first time! 🎉 Created by @comeflywithjo.bsky.social via our public engagement awards, the game sparks discussion on choosing research models and replacing animal use. 📦 Get your free pack: nc3rs.org.uk/3rs-resource...

Read our new briefing paper, showcasing how the next generation of preclinical in vitro models can replace animal use, better recapitulate human physiology and disease and increase the efficiency of drug development: nc3rs.org.uk/news/briefin...

ARRIVE 2.0 turns five! Since we launched our updated guidelines in July 2020, we have developed a suite of resources to embed transparency and reproducibility throughout the research lifecycle, from planning to peer review: arriveguidelines.org/resources

In the latest activity supported by our public engagement awards, this week over 80 secondary school students explored refinements for rodents in neuroscience research and learned about computational approaches to replace their use. Find out more about the scheme: nc3rs.org.uk/our-funding-...

🏆 Online 3Rs Prize ceremony, 23 July: nc3rs.org.uk/events/3rs-p... Join us, Prize sponsors GSK and NC3Rs Board Chair Professor Dame Julia Buckingham to hear about the outstanding 3Rs impacts recognised by this years’ Prize, including non-animal derived antibodies and in vitro antivenom testing.

Wax moth larvae are growing in use as a partial replacement for rodents, from infection and immunity research to toxicology. The fourth annual Galleria mellonella workshop is organised by Dr Rachel Clare in collaboration with @gmrc.bsky.social 🗓️15 September 👉Register: nc3rs.org.uk/events/galle...

📑 New publication with @hesiglobal.bsky.social! Our comprehensive review of aquatic endocrine assays aims to ensure that data is robust and supports effective decision making, reducing test repeats and the need for some studies using high numbers of animals. 👉 academic.oup.com/etc/article/...

A scalable system to assess antibody performance and build confidence in recombinant reagents to replace animal-derived antibodies has won this year's International 3Rs Prize, sponsored by GSK: nc3rs.org.uk/news/buildin...

In 2024 we awarded almost £21k to 13 public engagement projects, reaching 3,000+ people across 17 events. Genevieve Barr explores the projects, from inspiring the next generation of scientists to creating resources for the community to use in their own 3Rs activities: nc3rs.org.uk/news/public-...

While in Hong Kong we also spent three days providing training for over a hundred animal technicians, vets, ethical review members and researchers on how to promote and support reliable and transparent animal research.

Last week, Esther Pearl and Nathalie Percie du Sert travelled to Hong Kong for the Hong Kong Laboratory Animal Sciences Society (HKLASS) symposium hklass.org. HKLASS is relatively new and it was amazing to see so much enthusiasm for the 3Rs.

WEBINAR: Improving the lives of laboratory zebrafish Join Professor Robert Gerlai tomorrow to explore how optimising housing and his award-winning work on handling methods can improve both zebrafish welfare and research data quality. 📅 18 June ⏰ 14.00 – 15.00 (BST) 🐟 nc3rs.org.uk/events/welfa...

In our 20th issue of Tech3Rs we look back over 20 years of working with technical staff to deliver 3Rs advances in animal facilities. We re-visit two previous Tech3Rs champions, cover support to share your 3Rs work, alongside 3Rs papers of interest and webinars: nc3rs.org.uk/3rs-resource...

On the final day of our PhD student summer school, students explored the importance of reporting detailed methods though a reproducibility workshop that saw them attempt to re-build Lego structures relying only on written instructions.

Day two of our summer school kicked off with Güneş Taylor from the University of Edinburgh. She discussed the challenges and benefits of communicating research with diverse audiences and shared advice from her personal experiences of speaking to the public about animal use in science.