New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

Why do many aging interventions come & go, yet Caloric Restriction (CR) remains a robust pillar, extending healthspan across species? Its benefits are even noted in ancient eastern texts like The Yellow Emperor’s Classic of Internal Medicine!

The importance of the immune system for healthy aging. A large multi-cohort study identifies a mechanism of immune resilience with substantial impact for outcomes onlinelibrary.wiley.com/doi/10.1111/...

Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of

Biological sex is a key modifier of #aging phenotypes, including #Brain 🧠 aging. See this piece out today in #Neuron, spearheaded by @denadubal.bsky.social, co-authored by #YousinSuh, @ctmurphy1.bsky.social and myself on the topic: www.sciencedirect.com/science/arti... #GeroSky #SexDifferences

Interested in brain aging? We are super excited to share our new review!! "Brain aging and rejuvenation at single-cell resolution" 🧪🧠 Massive CONGRATS to Eric Sun, Rahul Nagvekar, and Angie Pogson, three phenomenal graduate students in the lab!! authors.elsevier.com/sd/article/S...

A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience

Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!