David Villarroel
@dvillarroelc.bsky.social
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Postdoc @UCL IoN. Inherited neuropathies, axonal transport, and a whiff of cytoskeleton
reposted by
David Villarroel
Anh Hoang Le 🏳️🌈
3 months ago
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
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Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.
https://www.science.org/doi/10.1126/sciadv.adu6361
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reposted by
David Villarroel
James N. Sleigh
4 months ago
Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of
#AxonalTransport
are impaired in aged mice:
www.sciencedirect.com/science/arti...
@dvillarroelc.bsky.social
@andrewtosolini.bsky.social
@alessiovagnoni.bsky.social
@uclqsion.bsky.social
#aging
add a skeleton here at some point
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reposted by
David Villarroel
James N. Sleigh
9 months ago
Short perspective from Dr. Ellie Rhymes on shared mechanisms and phenotypes in ARS-related neuropathies:
journals.lww.com/nrronline/ci...
#CMT
#neuropathy
#PeripheralNerve
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