Jordan Ray
@jordanray.bsky.social
📤 105
đź“Ą 151
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Biology PhD Candidate at MIT studying lysosomal RNA degradation. UC Berkeley Alum
pinned post!
I am excited to share my graduate work in the Sabatini and
@bartellab.bsky.social
labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation!
www.biorxiv.org/content/10.1...
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
https://www.biorxiv.org/content/10.1101/2025.09.09.674968v1
2 months ago
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Jordan Ray
David Bartel's Lab
4 days ago
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage:
www.biorxiv.org/content/10.1...
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mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
https://www.biorxiv.org/content/10.1101/2025.11.06.686990v1
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Jordan Ray
David Bartel's Lab
28 days ago
Check out the latest work from our lab, led by Arash Latifkar
@ara-latifkar.bsky.social
,
www.biorxiv.org/content/10.1...
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mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
https://www.biorxiv.org/content/10.1101/2025.10.09.680815v1
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Jordan Ray
David Bartel's Lab
2 months ago
Check out the latest work from Jordan Ray (
@jordanray.bsky.social
), a collaboration between our lab and David Sabatini’s lab.
www.biorxiv.org/content/10.1...
(1/2)
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Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
https://www.biorxiv.org/content/10.1101/2025.09.09.674968v1
1
12
4
I am excited to share my graduate work in the Sabatini and
@bartellab.bsky.social
labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation!
www.biorxiv.org/content/10.1...
loading . . .
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. While lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene...
https://www.biorxiv.org/content/10.1101/2025.09.09.674968v1
2 months ago
0
34
18
reposted by
Jordan Ray
David Pla Martin
7 months ago
Are u tired of reading about tariffs? Then take a look to our last work!
@science.org
www.science.org/doi/10.1126/...
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Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
https://www.science.org/doi/10.1126/sciadv.adr6415
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Very cool.
www.science.org/doi/10.1126/...
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Exogenous RNA surveillance by proton-sensing TRIM25
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
https://www.science.org/doi/10.1126/science.ads4539
7 months ago
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Jordan Ray
David Bartel's Lab
7 months ago
Don’t miss this Q&A with Dr. Michelle Frank (
@michelle-frank.bsky.social
), an awesome postdoc in our lab!
add a skeleton here at some point
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add a skeleton here at some point
8 months ago
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reposted by
Jordan Ray
Matthew Harry Hall
8 months ago
Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites
www.biorxiv.org/content/10.1...
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Functional microRNA targeting without seed pairing
MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Compleme...
https://www.biorxiv.org/content/10.1101/2025.03.03.641270v1
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Jordan Ray
Hank Adelmann
11 months ago
We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!
add a skeleton here at some point
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reposted by
Jordan Ray
David Bartel's Lab
11 months ago
Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!
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Jordan Ray
Itai Yanai
12 months ago
If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!
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www.cell.com/cell/fulltex...
Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.
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snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification
Transcriptome-wide mapping of snoRNA targets reveals mRNA-snoRNA-7SL RNA ternary interactions, which facilitate nascent protein translocation to the ER and subsequent secretion.
https://www.cell.com/cell/fulltext/S0092-8674(24)01269-8?dgcid=raven_jbs_aip_email
12 months ago
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