Mechanism of nucleolytic degradation of human ribosomes https://www.biorxiv.org/content/10.64898/2026.04.26.720784v1

Really great work showing how LARP1 senses 40S levels to regulate TOPs www.biorxiv.org/content/10.6...

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

A Preoptic Neurocircuit That Modulates Metabolic Flexibility https://www.biorxiv.org/content/10.64898/2026.01.15.699760v1

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

Check out the latest work from Jordan Ray (@jordanray.bsky.social), a collaboration between our lab and David Sabatini’s lab. www.biorxiv.org/content/10.1... (1/2)

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...

Very cool. www.science.org/doi/10.1126/...

Don’t miss this Q&A with Dr. Michelle Frank (@michelle-frank.bsky.social), an awesome postdoc in our lab!

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Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites www.biorxiv.org/content/10.1...

We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!

Bartel Lab bids a fond farewell to our incredible lab manager, Asia Stefano. Wishing you all the best on your new adventures in the Rocky Mountains, Asia—thank you for the amazing time we shared together!

If you've been meaning to check out the Night Science Podcast, this is the perfect episode to get started with. Everyone is telling me it's our best one yet!

www.cell.com/cell/fulltex... Quite a cool novel role for a snoRNA. I am curious how the structured domain of the SRP RNA becomes accessible for snoRNA73 binding and if this would disrupt SRP19 binding to the SRP RNA.