Rare disease treatment relies on the combined efforts of clinicians, researchers, and families. Yet these people rarely find themselves in the same room. BridgeRD brought them together last week to address the challenges of understanding, diagnosing, and treating rare diseases. 🔗 shorturl.at/pJXcu

From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly. wi.mit.edu/news/alterna...

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Congratulations to @jimmy-ly.bsky.social on this well-deserved recognition! His research looking at variants of known proteins offers new insight into rare genetic disorders. tinyurl.com/5xfc3feh

Honoured to receive the IMP Birnstiel Award this year! So grateful to my mentor @iaincheeseman.bsky.social for all of his help and encouragement!! Very thankful to the @whiteheadinstitute.bsky.social community and the wonderful collaborations within the institute—especially @bartellab.bsky.social 😊🥳

New preprint! Graduate student Océane Marescal leverages quiescence - proliferative hibernation - to reveal unexpected dynamics for “constitutively”-localized centromere proteins. To understand the logic of cell division, you need to consider non-dividing cells. www.biorxiv.org/content/10.1...

I am incredibly grateful and honored to be recognized with the Keith Porter Prize 🥹🥳 — thank you, @ascbiology.bsky.social and @iaincheeseman.bsky.social for being the best mentor!! Congratulations to the other awardees and I am looking forward to meeting everyone in Philly

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

Beautiful work by Katya Khalizeva from @iaincheeseman.bsky.social lab, uncovering a surprising feedback loop to globally suppress mRNA decay during mitosis! This helps explain how cells maintain their transcriptome during a mitotic arrest without new transcription! www.biorxiv.org/content/10.1...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10d.bsky.social‬): Brieflow. A game changer for OPS + new biological insights www.biorxiv.org/content/10.1...

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below. www.biorxiv.org/content/10.1...

Excited to share my work with @iaincheeseman.bsky.social! We show that alternative translation produces differentially localized protein variants mutated in rare human diseases. This was a fun collaboration, blending cell biology with evolution and clinical genetics! www.biorxiv.org/content/10.1...

Countdown to an epic new pre-print. Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!