I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...

Congratulations to @jimmy-ly.bsky.social on this well-deserved recognition! His research looking at variants of known proteins offers new insight into rare genetic disorders. tinyurl.com/5xfc3feh

Honoured to receive the IMP Birnstiel Award this year! So grateful to my mentor @iaincheeseman.bsky.social for all of his help and encouragement!! Very thankful to the @whiteheadinstitute.bsky.social community and the wonderful collaborations within the institute—especially @bartellab.bsky.social 😊🥳

New preprint! Graduate student Océane Marescal leverages quiescence - proliferative hibernation - to reveal unexpected dynamics for “constitutively”-localized centromere proteins. To understand the logic of cell division, you need to consider non-dividing cells. www.biorxiv.org/content/10.1...

I am incredibly grateful and honored to be recognized with the Keith Porter Prize 🥹🥳 — thank you, @ascbiology.bsky.social and @iaincheeseman.bsky.social for being the best mentor!! Congratulations to the other awardees and I am looking forward to meeting everyone in Philly

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

Beautiful work by Katya Khalizeva from @iaincheeseman.bsky.social lab, uncovering a surprising feedback loop to globally suppress mRNA decay during mitosis! This helps explain how cells maintain their transcriptome during a mitotic arrest without new transcription! www.biorxiv.org/content/10.1...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Optical Pooled Screening has transformed large-scale cell biology, but lacks robust end-to-end computational strategies to process these Tb-sized datasets. New from Di Bernardo et al (@mat10d.bsky.social‬): Brieflow. A game changer for OPS + new biological insights www.biorxiv.org/content/10.1...

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below. www.biorxiv.org/content/10.1...

Excited to share my work with @iaincheeseman.bsky.social! We show that alternative translation produces differentially localized protein variants mutated in rare human diseases. This was a fun collaboration, blending cell biology with evolution and clinical genetics! www.biorxiv.org/content/10.1...

Countdown to an epic new pre-print. Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!