Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

Huge thanks to all authors on this paper @sami-c.bsky.social @abidalilab.bsky.social and @leonmichalski.bsky.social . And to @carter-lab.bsky.social for support, guidance and the environment to do this work!

We solved cryo-EM structures of dynein–dynactin with 5 adaptors: RAB11FIP3, NIN, TRAK1, BICD2, HOOK3 Across EF-hand, CC1-box, and Hook families. Despite this diversity… the overall architecture is basically the same.

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...