Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome go.nature.com/3RMNwPW

www.nature.com/articles/s41... #microsky

🧪🦠 Streptomyces rimosus "Das Antibiotikum mit dem Namen Manikomycin wirkt gegen multiresistente Bakterien und könnte langfristig zur Entwicklung neuer Behandlungsoptionen beitragen" www.welt.de/gesundheit/a... 👇 www.nature.com/articles/s41...

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM - pubmed.ncbi.nlm.nih.gov/42151144/

New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

🔽 (the first) ribosomal E-site targeting antibacterial; producer avoids self-toxicity by rRNA methylation. #Ribosome #AMR

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first. links.springernature.com/f/a/Q0JMeeZK...

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM pubmed.ncbi.nlm.nih.gov/42151144/ #cryoem

New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

If you are looking for a PhD with great science, great people, and great views of Hamburg, here is your chance! (In the lab of my wonderful former supervisor).

VitriFlex: An Open-Source, Modular, and Customizable Robotic Platform for Cryo-EM Grid Preparation www.biorxiv.org/content/10.1101/2025.07.24.666634v1 #cryoem

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...

Excited to share that I received the Best Poster Prize at Translation UK 2025 in Edinburgh! Grateful to the @biochemsoc.bsky.social and Bioscience Reports for supporting young researchers. #TranslationUK2025 #StructuralBiology #CryoEM

New preprint alert! Read about Manikomycin, a hidden antibiotic from Streptomyces rimosus that targets the ribosomal E site, revealing a novel MOA against MDR pathogens. Even old strains have surprises. 🧬💥 doi.org/10.21203/rs.... #Antibiotics #CryoEM #Microbiology

Heading to #TranslationUK2025? Come find me at Poster P002 – I’ll be showing how kasugamycin, edeine & GE81112 target different steps of 30S initiation complex formation 🧬 Let’s chat ribosomes, antibiotics & translation! @biochemsoc.bsky.social #BiochemEvent #SciComm

🧬 Spoke at the 2nd Polish RNA Biology Meeting in Poznań! Presented my PhD work on how kasugamycin, edeine & GE81112 disrupt distinct steps of 30S initiation complex formation using cryo-EM. Grateful for the engaged crowd & vibrant discussions! #CryoEM #RNA

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with inada and Zaher labs. Data collected by Bertrand Beckert at the DCI EPFL www.pnas.org/doi/10.1073/...

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.

Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY! Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications. landau-cssb.de/meeting-of-f...

Blocking IF3N delays bacterial translation initiation www.biorxiv.org/content/10.1101/2025.03.14.643242v1 #cryoem

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation pubmed.ncbi.nlm.nih.gov/40075065/ #cryoem

Congrats to Haaris @haarissafdari.bsky.social for successfully defending his PhD thesis today - 2 days after his second first author paper came out! Good timing!

Fascinating things happening at the IIMCB nowadays! This is one of the first patterns milled with our new TFS Hydra Bio Plasma-FIB, and - most likely - the smallest IIMCB logo ever!

Full link: www.nature.com/articles/s41...

Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways. Read more: www.nature.com/articles/s41...

Our study on translation initiation inhibitors now published after peer review at nature.com/articles/s4146…. Great collaboration with Pohl Milon and team. Data collected at @cssbhamburg.bsky.social

Excited to share my first-author paper in Nature Communications! Using cryo-EM, we reveal how kasugamycin, edeine, and GE81112 inhibit bacterial translation initiation by binding the 30S ribosomal subunit in distinct ways. Read more: www.nature.com/articles/s41...

#cryoET of Mycoplasma pneumoniae Chloramphenicol-bound ribosomes at a global 3.0 Å resolution www.nature.com/articles/s41...

Amazing work!

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

Thrilled to share our recent discovery from the Agrawal and Ojha Labs: an Actinobacteria-specific ribosome hibernation factor bound to Mycobacterium tuberculosis ribosomes isolated from biofilms. www.biorxiv.org/content/10.1... @cryoempapers.bsky.social @mycobacterium.bsky.social

Bluesky now tracked as Altmetric research attention source | Research Information https://www.researchinformation.info/news/bluesky-now-tracked-as-altmetric-research-attention-source/

We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile #microsky #phage #evolution #cryoEM #AFM www.whiterose-mechanisticbiology-dtp.ac.uk/yorkshire-bi...

Considering a PhD in molecular biology? There’s still time to apply to join the LMB in October 2024. Applications close on 3rd DEC. Visit our website for more info: www2.mrc-lmb.cam.ac.uk/students/int...

Starter packs are a good indicator of the size of Bluesky adoption. Last week they were called something like 'Cell Biologists', this week it is 'Cytoskeleton', and next week we should see the first 'Connoisseurs of microtubule plus end motors' popping up.