ICYMI: New online! A new antibiotic scaffold hits a new target

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the 2nd paper in Nature *this month* by Gerard D. Wright! that's the 1st one www.nature.com/articles/s41...

A 'megacluster' of genes found in a common soil bacterium can produce a range of antibiotics that can act against multi-drug-resistant bacteria go.nature.com/4xObGKf

🧵 study https://bsky.app/profile/marcveld.bsky.social/post/3mopvubj67f2h

Yes ! www.nature.com/articles/s41...

Manikomycin, which blocks the exit site of the protein-producing machinery in bacteria, is the fourth major discovery from antimicrobial resistance expert Gerry Wright’s research team in recent months. news.mcmaster.ca/mcmaster-res... #CdnPSE (2/2)

“the compound—known as manikomycin—is the first antibacterial agent known to target the E-site in the large ribosomal subunit, opening the door to an entirely new class of treatments.” www.genengnews.com/topics/infec...

New Antibiotic Found in Dirt Targets Superbugs in a Way ‘Never Been Seen Before’: A collaborative team of U.S., Canadian, and German researchers has discovered manikomycin, a novel peptide antibiotic derived from the soil bacterium *Streptomyces rimosus*, the same sou… https://ranked.news/976616?u=b

🧫 Antibiotikum gegen multiresistente Keime entdeckt: Ein Forschungsteam unter UHH-Beteiligung hat in einem bereits untersuchten Bodenbakterium den neuen Wirkstoff Manikomycin gefunden. Die Entdeckung zeigt: Bekannte Mikroorganismen besitzen weiterhin Potenzial für die Entwicklung neuer Antibiotika.

New class of antibiotics? Please. "The compound, called manikomycin, was identified by a team led by McMaster..Early testing showed it was effective against several priority pathogens, including salmonella, E. coli & klebsiella. “What makes this exciting is that it’s a brand new unique structure”

Canadian-led team of scientists discover new antibiotic hidden in decades-old bacterium https://www.ctvnews.ca/sci-tech/article/canadian-led-researchers-discover-antibiotic-that-targets-drug-resistant-bacteria/ ↷ canadahealthwatch.ca/featured 🍁

Manikomycin A is not going to be a drug, but it *is* a very promising starting point for new antibiotic development www.science.org/content/blog...

Biochemiker und Pharmazeuten aus den USA, Kanada und Deutschland haben gemeinsam ein neues, natürlich vorkommendes #Antibiotikum entdeckt: #Manikomycin. https://gizmodo.com/new-antibiotic-found-in-dirt-targets-bacteria-in-a-way-never-been-seen-before-2000770712

Ribosome hibernation in archea with HibA, with a bacterial line hpf/raiA domain rdcu.be/foDtr

This is such a big fucking deal and it's also so cool!!!

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome Very important! A new antibiotic working in a very different way. www.nature.com/artic... 1/5

Flipping antimicrobial peptides in the exit tunnel of the bacterial ribosome | Nature Communications https://www.nature.com/articles/s41467-026-74007-x

A narrow ribosome tunnel can act as a checkpoint for bacterial protein production. Some peptides block it directly, while another can trigger a temporary pause under specific stress. doi.org/hb62q9

🚨 Nature Reviews Microbiology highlights our Nature paper on Manikomycin. A new antibiotic scaffold targeting the ribosomal E-site → new mechanism against drug-resistant bacteria. www.nature.com/articles/s41...

🚨 Nature Reviews Microbiology highlights our Nature paper on Manikomycin. A new antibiotic scaffold targeting the ribosomal E-site → new mechanism against drug-resistant bacteria. www.nature.com/articles/s41...

#NatMicroPicks Hidden in plain sight! 💊🦠 Assessing overlooked minor compounds uncovered a new antibiotic, manikomycin, from well-studied Streptomyces species that kills bacteria by uniquely targeting the ribosomal E-site #MicroSky www.nature.com/articles/s41...

Das hört sich nach einer sehr guten Nachricht an. #Antibiotika „Manikomycin is the first antibacterial agent, to our knowledge, to target the critical but underexplored E-site in the large ribosomal subunit, highlighting its value as a lead for developing new antibiotics.“

🚨 Our Nature paper on Manikomycin is a Research Highlight in Nature Reviews Drug Discovery. A new antibiotic. A new ribosomal target (E-site). Activity against MDR pathogens. doi.org/10.1038/d415...

🚨 Our Nature paper on Manikomycin is a Research Highlight in Nature Reviews Drug Discovery. A new antibiotic. A new ribosomal target (E-site). Activity against MDR pathogens. doi.org/10.1038/d415...

👉 A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome! www.nature.com/articles/s41... @nature.com #manik

An old microbe, a new antibiotic, and a new target. 🦠 Thrilled to see our @nature.com paper on Manikomycin featured in @science.org magazine blog. MKM is the first antibiotic shown to target the bacterial ribosome E-site. www.science.org/content/blog...

An old microbe, a new antibiotic, and a new target. 🦠 Thrilled to see our @nature.com paper on Manikomycin featured in @science.org magazine blog. MKM is the first antibiotic shown to target the bacterial ribosome E-site. www.science.org/content/blog...

Researchers say they have used a precise genome-editing technique called base editing to alter the genome of human embryos for the first time, an announcement that prompted both excitement and dismay. go.nature.com/3RUBKD6

Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome go.nature.com/3RMNwPW

www.nature.com/articles/s41... #microsky

🧪🦠 Streptomyces rimosus "Das Antibiotikum mit dem Namen Manikomycin wirkt gegen multiresistente Bakterien und könnte langfristig zur Entwicklung neuer Behandlungsoptionen beitragen" www.welt.de/gesundheit/a... 👇 www.nature.com/articles/s41...

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM - pubmed.ncbi.nlm.nih.gov/42151144/

New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

🔽 (the first) ribosomal E-site targeting antibacterial; producer avoids self-toxicity by rRNA methylation. #Ribosome #AMR

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first. links.springernature.com/f/a/Q0JMeeZK...

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...