A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecru...

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

Two year postdoc position available in the Sparte lab at IGDR to investigate the crosstalk between ADP-ribosylation and SUMOylation signaling at stressed replication forks

#ScientificResult | A collaborative work by the Huet group at IGDR and the Suskiewicz team at CBM discovers how SIAH1 polymerization could improve the clearing of protein aggregates involved in certain neurodegenerative diseases. igdr.univ-rennes.fr/en/proteins-... pubmed.ncbi.nlm.nih.gov/39910688/

📢Are you planning to do a #PhD in #Biology? There's still a month to apply at #IGDR PhD call! Apply before April 21st, 1:00 pm 7 to 9 positions ℹ️https://igdr.univ-rennes.fr/en/application-igdr-phd-program cc @cnrs-bretagneloire.bsky.social @insermgrandouest.bsky.social @rennesuniv.bsky.social

Here is a link to the article: onlinelibrary.wiley.com/share/author... We're very happy to see it published in a society journal, The FEBS J. It's another great collaboration with the team from Rennes led by Sébastien Huet @spartelab.bsky.social . Thanks to @ercresearch.bsky.social for funding.

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

This is a cover design that wasn't accepted, showing SIAH1 multimers on top of cells (SIAH1 red, actin green). We were not able to visualise SIAH1 chains in vitro, as we could only purify N- or C-term halves of SIAH1 separately: the blue chains are made from combined dimeric structures of each half.

What better occasion for our first post on Bluesky than this? Congratulations to Dr. Eva Pinto for successfully defending her thesis, "Study of ADP-ribose-dependent chromatin remodeling processes occurring at early stages of the DNA damage response." 🧬🔬