NEXT WEEK—join Dr. Barnaby Levin at the AIMS Annual Conference, April 17 at ASU. Catch up with the Arizona imaging and microanalysis community, exchange ideas & learn about the latest research. https://azmicroscopy.org/events/

IN JUST TWO WEEKS! April 22nd Direct Electron will be presenting a webinar: New Camera, Old Microscope - how to bring in new capabilities at a lower cost in TEM Dr. Carter Francis and Dr. Paul Voyles will show you how you can get great results! https://ow.ly/WBra50YCFar

Registration is open! April 22nd Direct Electron will be presenting a webinar: New Camera, Old Microscope - how to bring in new capabilities at a lower cost in TEM Dr. Carter Francis will be joined by Dr. Paul Voyles to show how to get great results with this approach. https://ow.ly/WBra50YCFar

Save the date! April 22nd Direct Electron will be presenting a webinar: New Camera, Old Microscope - how to bring in new capabilities at a lower cost in TEM Join us to learn how researchers are getting great results combining a new camera with their old microscopes.

ICYMI: In a direct comparison on the same sample, Apollo outperformed both K3 and DE-64—achieving 2.24 Å resolution vs ~2.9 Å for K3. Higher detail per particle and better DQE make Apollo the clear leader in cryo-EM detector performance. Read more: https://ow.ly/aF7950XgCWZ

Catfish have tails—and so does their herpesvirus. Researchers at the University of Glasgow used cryo-EM (Apollo on a JEOL CryoARM 300) to study giant viruses and uncover their structure and evolution over 400 million years. https://www.biorxiv.org/content/10.64898/2026.02.13.705735v1.full.pdf

NEXT WEEK: DE's own Dr. Carter Francis continues the GLMS webinar series on HyperSpy. Part 3 focuses on EELS analysis using the eXSpy Python package for advanced multi-dimensional microscopy data processing. March 19, 12 PM EST. Register here: https://ow.ly/ECjE50YtPcZ

Direct Electron R&D Scientist Carter Francis shares his thoughts on why open source matters — for science, collaboration, and the future of microscopy. Read his open letter here: https://directelectron.com/statement-on-open-source-microscopy-software/

Cryo-EM reveals how a bat coronavirus related to MERS may jump to mink — and potentially humans. Researchers from Yale and NIH used Apollo to solve the HKU5 spike–ACE2 structure, uncovering a unique binding strategy and host range. Read the study: https://doi.org/10.1038/s41467-025-61583-7

ICYMI: HyperSpy wins the People’s Choice Award! The open-source Python library for interactive analysis of complex materials data—co-developed with major contributions from Direct Electron scientist Carter Francis—was honored at France’s 2025 Open Science Awards. https://ow.ly/fmvu50Yomlr

We’ve added our latest webinar to the product demos and technical presentations on our Videos page. Explore recordings covering our cameras, workflows, and real-world research applications. Visit: https://directelectron.com/videos/

Missed our recent webinar on the DE API for Direct Electron cameras and scan controllers? The recording is now on YouTube! Explore integration strategies and advanced workflow control with R&D Scientist Dr. Carter Francis. View the full recording: https://youtu.be/kJi1kLvHcGo

Our Applications Scientist Dr. Barnaby Levin will be will be talking about MAPS Detectors for TEM at the Transmission Electron Microscopy for Materials Research Gordon Research Conference, February 15–20. Don't miss him if you're there & follow us for updates. Learn more: https://ow.ly/yrRM50YfrVF

First-ever EBSD orientation maps of hafnia & hafnon: using SEMCam + dictionary indexing, researchers overcame beam sensitivity & low symmetry challenges in ceramics. A new path for difficult materials. Read more: https://ow.ly/7Mn850YeA3K

API WEBINAR - WEDNESDAY, FEB 11! Join R&D Scientist Carter Francis for a practical demo, learn to use Python to control and automate DE cameras for live data visualization, experiment automation, Jupyter workflows, and other new features. Sign up here: https://ow.ly/hAOz50Y5Jrz

Tired of manual bottlenecks slowing your research? Join our free webinar with R&D Scientist Carter Francis to learn how Python-based camera control enables experiment automation, live data visualization & reproducible workflows. Feb 11, 9am PST. Register here: https://ow.ly/FABK50Yas1r

API WEBINAR - ONE WEEK, FEB 11! Join R&D Scientist Carter Francis for a practical demo, learn to use Python to control and automate DE cameras for live data visualization, experiment automation, Jupyter workflows, and other new features. Sign up here: https://ow.ly/hAOz50Y5Jrz

API WEBINAR - FEBRUARY 11th! Learn how to use Python to control and automate Direct Electron cameras. Join R&D Scientist Carter Francis for a practical webinar covering live data visualization, experiment automation, Jupyter workflows, and new features. Sign up here: https://ow.ly/cioN50Y5Jrl

Our Applications Scientist Dr. Barnaby Levin is attending the Liquid Phase Electron Microscopy Gordon Conference this week, where he’s presenting a poster on in situ TEM and in situ 4D STEM with fast direct detectors. If you’re at the meeting, don’t miss it! https://ow.ly/O0Zv50Y5Cbj

Researchers at UCLA show you don’t need a dedicated cryo-EM to get world-class results. Using an adapted entry-level TEM, they achieved 1.95 Å apoferritin—comparable to top-tier systems—pointing to a more accessible future for cryo-EM. Read more: https://doi.org/10.1093/mam/ozae044.364

What makes our direct detectors so special? Let our customers tell you! Learn all about DE-64 & Direct Electron's other ultra-fast cameras for Electron Microscopy & CryoEM at https://directelectron.com/products/

Unlocking atomic detail in seconds: Apollo enables high-speed, low-dose MicroED for microscale and nanoscale crystals—accurate structure solutions in less than a minute of data collection. Learn more about these groundbreaking results: https://ow.ly/SB8k50Y0ocO

Want to know what sets Direct Electron apart? Let our satisfied customers tell you! To learn more about Apollo & our other ultra-fast cameras for Electron Microscopy & CryoEM, visit https://directelectron.com/products/

We’re excited to share a new Journal of Virology study where researchers used our Apollo camera to map VEEV at high resolution and identify a cross-neutralizing antibody that could support development of a pan-alphavirus therapeutic. Read the paper: https://ow.ly/7Z3850XTLIU

Proud to see the Apollo camera supporting new H5Nx bird flu research in Nature Microbiology. NIH scientists imaged 500 antibodies from an H5N1-vaccinated patient and identified 5 that cross-neutralize multiple strains—key for future vaccine design. https://www.nature.com/articles/s41564-025-02137-x

Wishing you a Happy New Year filled with research breakthroughs, innovative discoveries, and scientific milestones made possible by the Most Advanced Direct Detection Cameras for High-Speed Electron Microscopy!

New paper from the Gianola group (UC Santa Barbara)! The first-ever EBSD patterns sliced by electron energy, enabled by direct detection with the DE-SEMCam. Results vs EMSoft simulations show how energy filtering sharpens HR-EBSD versus EBSD patterns. Read it here: https://ow.ly/zeaW50XMLOX

HyperSpy wins the People’s Choice Award! The open-source Python library for interactive analysis of complex materials data—co-developed with major contributions from Direct Electron scientist Carter Francis—was honored at France’s 2025 Open Science Awards. https://ow.ly/5ZJu50XL9zo

Learn HyperSpy from one of its pioneers. DE's Dr. Carter Francis (HyperSpy steering council, lead developer of pyxem) kicks off the GLMS HyperSpy webinar series with an intro for TEM users. Sign up here: https://umich.zoom.us/webinar/register/WN_NcKlNfTSQW-ppeq4tLivuQ#/registration

Where in the world is Direct Electron? Applications Scientist Dr. Barnaby Levin was just at the 2025 MRS Fall meeting, so if you guessed Boston, you got it right! Now for the real challenge—can you name the building?

Dr. Barnaby Levin says "it was great to be at MRS and hear about new & exciting science!” Direct Electron is on the move again—stay tuned for more stops around the globe.

In a direct comparison on the same sample, Apollo outperformed both K3 and DE-64—achieving 2.24 Å resolution vs ~2.9 Å for K3. Higher detail per particle and better DQE make Apollo the clear leader in cryo-EM detector performance. Read more: https://ow.ly/aF7950XgCWZ

Don't miss Dr. Barnaby Levin tomorrow, 2:45 PM at the Fall MRS Meeting presenting: “Advances in Event-Based Direct Detectors for In Situ TEM.” Hear how next-gen detectors + cutting-edge software are unlocking ultrafast, high-res imaging of dynamic processes. Learn more: https://ow.ly/g6vG50XAizy

🍁 We’re grateful for innovation, collaboration, and all the brilliant minds driving scientific progress. Wishing you and yours a day of gratitude, connection, and lots of tasty food! 🦃

Thanks to all who played along with "Where in the World is Direct Electron?" this week! Here’s another shot from Kalani’s latest stop in Europe. This time the landmark is a giveaway — so, if you guessed Strasbourg, France, you nailed it!

Where in the World is Direct Electron? Senior Applications Scientist Michael Spilman (right) stopped by Aalto University in Finland to visit OtaNano Senior Scientist Jani Seitsonen & their JEOL 3200FSC, now running a brand-new Apollo (right next to their trusty DE-16).

Where in the world is DE Director of R&D Dr. Benjamin Bammes This week, it's the Rice University Center for Nanoscale Imaging Sciences Conference, attending Prof. Steve Ludtke’s talk on how continuous-rotation tomography + the DE Apollo improves contrast & reduces 3D artifacts.

Our R&D Scientist Kalani Moore is out in the field supporting our customers — but Where in the World is he? Recognize the beautiful building behind him? Give us your best guess!

To get the most for your money, you must look beyond purchase price. Maintenance & service costs can add up fast! Become one of our happy customers by choosing our cutting-edge systems with low-cost service contracts that are both more affordable & more reliable!

Did you know that we achieved record-breaking 1.85 Å resolution for a cryo-EM helical reconstruction with our Apollo detector? Learn more about the many revolutionary breakthroughs that make up the Direct Electron legacy. Visit: https://directelectron.com/timeline/

Direct Electron R&D Scientist Carter Francis shares his thoughts on why open source matters — for science, collaboration, and the future of microscopy. Read his open letter here: https://directelectron.com/statement-on-open-source-microscopy-software/

NEW VIDEO! R&D Scientist Carter Francis demonstrates how to capture, visualize, and analyze 4D STEM datasets using Mission Control + Dimension — then extend your analysis with HyperSpy + pyxem. Watch the full demo: https://youtu.be/Z498tX42Nvg

HAPPY HALLOWEEN! It's no 🎃 trick, so treat 🍭 yourself to all the knowledge in our spooktacular Learning Center! Say "BOO" to Bad Data! 👻 Don't be batty, 🦇 visit now! https://directelectron.com/learning-center/

With our Apollo event-based detectors, you'll get ultra-fast speed & unrivaled sensitivity, even in low-dose transmission applications. Let us help you secure funding! Visit our website for assistance writing a grant application today: https://directelectron.com/write-a-grant/

In a direct comparison on the same sample, Apollo outperformed both K3 and DE-64—achieving 2.24 Å resolution vs ~2.9 Å for K3. Higher detail per particle and better DQE make Apollo the clear leader in cryo-EM detector performance. Read more: https://ow.ly/pBFj50XgCWX

Thanks to everyone who stopped by to chat with Bob Monteverde at the recent MSSEM meeting in Colorado! If you missed him at the event, you can still connect with us anytime — visit our website to request a quote or learn more about our ultra-fast direct detectors for TEM. https://directelectron.com/

Director of Sales, Bob Monteverde, is headed to the Mountain States Society of Electron Microscopists meeting at CU Boulder TODAY! If you’re attending, be sure to connect with him and learn more about our cutting edge direct detectors for electron microscopy. Learn more: https://ow.ly/CTvR50Xc7sV

Discover the speed and sensitivity of Celeritas XS for 4D STEM! Dr. Kalani Moore recently presented to the Korean Society of Microscopy — and now you can watch the full series on YouTube: https://ow.ly/zYnT50XbmWV

Our Director of Sales, Bob Monteverde, will be at the AReMS Meeting at the University of Tennessee, Knoxville, Oct 9–10. Join scientists, engineers and students from across the region for two days of microscopy talks, exhibits and workshops. Learn more: ow.ly/a8v150X8KTp

DE's @csfrancis.bsky.social will be at the 2025 Great Lakes Microscopy Society Meeting TODAY, Oct 7 at the University of Michigan. The event, co-hosted by (MC)², brings together researchers and industry experts to share the latest in microscopy. Learn more: ow.ly/sai250X7vLV