Alessandro Romanel
@aromanel.bsky.social
π€ 9
π₯ 8
π 2
Head of the Bioinformatics and Computational Genomics Lab, CIBIO, University of Trento.
π¨ Out in NAR
@narjournal.bsky.social
! Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences. π Paper:
doi.org/10.1093/nar/...
π» DB:
bcglab.cibio.unitn.it/hapscoredb
#Bioinformatics
#Genomics
#ProteinLanguageModels
#CompBio
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HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences
Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h
https://doi.org/10.1093/nar/gkaf1184
about 1 month ago
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reposted by
Alessandro Romanel
Francesco Cambuli
about 1 year ago
Our latest collaborative project co-led by Dario De Felice, Alessandro Alaimo,
@bresdavide.bsky.social
, and Andrea Lunardi at CIBIO UniTrento π¬ 𧫠𧬠We generated pro-luminal prostate organoid models and found that common FOXA1 cancer indels are loss-of-function
www.embopress.org/doi/full/10....
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RarΞ³-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer | EMBO reports
imageimageLeveraging mouse adult prostate organoids reveals regulators of prostatic luminal lineage commitment. The androgen pathway together with retinoic acid/RarΞ³/Foxa1 signaling programs luminal p...
https://www.embopress.org/doi/full/10.1038/s44319-024-00335-y
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reposted by
Alessandro Romanel
Davide Bressan
12 months ago
Are you looking for a tool to analyze ChIP-seq data with spike-in control? Check out SpikeFlow π
academic.oup.com/nargab/artic...
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SpikeFlow: automated and flexible analysis of ChIP-Seq data with spike-in control
Abstract. ChIP with reference exogenous genome (ChIP-Rx) is widely used to study histone modification changes across different biological conditions. A key
https://academic.oup.com/nargab/article/6/3/lqae118/7744948
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