Philip Romero
@philromero.bsky.social
π€ 133
π₯ 148
π 5
Associate professor Duke BME www.romerolab.org
reposted by
Philip Romero
Chang Liu
about 1 month ago
Our new company, K2 Therapeutics, is off to the races to develop new antibody drugs that target multipass membrane proteins. We are hiring so check us out!
www.k2-tx.com/home#careers
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K2 Therapeutics
https://www.k2-tx.com/home#careers
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π Congrats to Nate for his awesome preprint! We used deep learning to design phages with complex infectivity and specificity profiles. Big shifts in host targeting come from just a few mutations! Training on multifunctional data enables precise control over protein properties π§¬
tinyurl.com/yc4wtn8h
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Multiobjective learning and design of bacteriophage specificity
To better understand and design proteins, it is crucial to consider the multifunctional landscapes on which all proteins exist. Proteins are often optimized for single functions during design and engi...
https://tinyurl.com/yc4wtn8h
4 months ago
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Congrats to Nathaniel and Sri for their exciting work teaching protein language models to generate beyond what evolution has explored. They introduce Reinforcement Learning from eXperimental Feedback (RLXF) to steer generation toward enhanced and non-natural functions
www.biorxiv.org/content/10.1...
add a skeleton here at some point
5 months ago
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πCongrats to Chase on her new preprint! She developed OMEGA--a simple method for assembling custom gene panels for as little as $1.50 per gene. Big step forward protein engineering and design!π§¬
www.biorxiv.org/content/10.1...
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Scalable and cost-efficient custom gene library assembly from oligopools
Advances in metagenomics, deep learning, and generative protein design have enabled broad in silico exploration of sequence space, but experimental characterization is still constrained by the cost an...
https://www.biorxiv.org/content/10.1101/2025.03.22.644747v1
6 months ago
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Finally joining social media after all these years!!
6 months ago
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