Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...

Stop using viridis

Collinearity of Decomposed Energy Terms in MM-GBSA Binding Free Energy Calculations https://www.biorxiv.org/content/10.64898/2026.06.24.734195v1

Incredible chart from @propublica.org. If you don’t follow enviro stuff closely, your instinct might be that the hold-your-nose solution (carbon capture from fossil fuels) would be the “pragmatic” one versus covering Earth in solar panels, which seems utopian. In fact it’s the opposite

"you're right - I not only ran 28.8 million fake conversations, I used them to train a competing model. That's not just a distillation attack - it's a breach of trust. Would you like me to: * Explore more deeply how to carry out distillation attacks * Draft a cease and desist letter

Every city’s got an ominous megastructure. Dallas, TX.

Me

lol www.biorxiv.org/content/10.6...

while you were touching grass i was crashing out online. while you were having fun i was misery posting. while you were at the gym i was picking fights with checkmarks. and now that you want to plan a beach trip with all your friends you come to me for help?

gwen does fantastic work as usual on some of the 401,000 trans people who’ve had to flee hostile territory in their own country in the past 18 months.

i do think social media exposed a lot of people to doing three of the scariest kinds of job (poet, psychoanalyst, celebrity) with zero training and now everyones mad theyre bad at it and its not a fun social life

oof summer continues

I spent the last month obsessed with finding colors that can't be displayed on a conventional screen. This is what I found. moultano.wordpress.com/2026/06/19/w...

it’s oof summer

elementary school: slavery caused the civil war high school: complicated economic issues caused the civil war College: slavery caused the civil war Grad school: the civil war was a struggle between feudalism and capitalism Your 30s: the civil war was a metaphysical struggle between Good and Evil

“I’ll meet Paxton at any time and any place if he will answer Texans’ questions about why he let admitted child sex offender Adam Hoffman walk free,” Talarico said, according to Texas Tribune reporter Alejandro Serrano. www.msn.com/en-ca/news/w...?

You're scrolling Reels and see a beautiful woman revealing the true ingredients in processed food. Into a beaker she pours: corn. The beaker fills, then overflows. She pours on. The corn covers the table, spills onto the floor. She can't control the corn now. An avalanche of corn floods the studio

If I was a sailor peg I would simply not lose my leg

This is why 🏳️‍🌈🏳️‍⚧️ Pride is important. A positive Pride display would have made all the difference to a closeted kid in a working-class town (Waltham, MA) like me in the 1970s: In my city library, there was a short book on the shelves that was an anti-gay manifesto (Dewey decimal 301.4). 1/3

Comparative Molecular Dynamics Characterization of Hair Keratin Unfolding Mechanics https://www.biorxiv.org/content/10.64898/2026.06.06.730563v1

Capitalism and Schizophrenia

presented without comment chemrxiv.org/doi/pdf/10.2...

On Tuesday, queer Houstonians mourned Persia Conway, a trans woman found dead last week. After grief, there was rage. Rage at Houston PD. Rage at rumors that Persia was someone she wasn't. But most of all, rage over another trans woman of color taken too soon: www.chron.com/culture/arti...

Paxton is suing my community (again) to stop a Pride celebration. www.cbsnews.com/texas/news/a...

happy pride from estrogen receptor alpha

If you die in Euphoria you die in real life

Somerville more like yummerville with all these treats

lmfao

Always seemed to me like the evolutionary dynamics here lead to free transcriptional switches. I wonder if anyone has modeled this

New fluoddity landing page. I have been entirely sniped by these lil guys fluoddity.mino.mobi

fly on, o great one. www.theguardian.com/music/2026/m...

I was just talking about this with people in the checkout line at the grocery store

Reviewers in two groups were given identical resumes for Emily Clarke and James Clarke and told they had used AI. Emily's was 2x as likely to raise doubts about competence. "She can't even write a CV herself." But James "just needed a bit of help." fortune.com/2026/05/10/i...

Damn, they basically got the book right

It turns out that a lot of the bafflingly poor metaphors used by LLMs (as opposed to repetitive linguistic constructs like — or “it’s not X, it’s Y”) are actually direct regurgitations from human-written bad fanfiction in the training data: tuhinchakrabarty.substack.com/p/ai-slop-gr...

gf in LA and accidentally uncovered a crazy google account that is mass farming google review points by using Gemini to farm images of Kim Jong Un in various local establishments www.google.com/maps/contrib...

What a man. A dragon-man.

You may have noticed I disappeared from social media after my launch of @beyondxandy.bsky.social I was violently attacked by a transphobe who recognized me and have been in the hospital and resting If you'd like to help me with my medical bills, please consider donating here: gofund.me/9328f91f2

I had missed this earlier but holy crap, Anthropic will turn an operating profit this quarter. I’m genuinely blown away by this. And set to more than double revenues QoQ. www.wsj.com/tech/ai/mind...

there was that regime CPA thread about The Deal texas had with the PMC and how it fell apart after trump

American science right now is basically 10,000 of these stories, all with their own heartbreaking specificity Lost careers, lost progress, lost discoveries I feel so sad every day for all we’ve lost and continue to lose 💔

Love this from @epigenci.bsky.social and collaborators. Always nice when beautiful mathematics and the methods needed to understand a biological problem coincide

Good news everyone! Fidget to your heart's content at g.mino.mobi/mole

Love these ensemble visualizations. It is remarkable that Kresten started this in 2004 (cool story later in the thread)

some really weird visualizations from the cutting room floor of my PhD

The joint entropy decomposes as S(X,Y) = S(X) + S(Y|X) so if S(Y|X) is constant over the set of environments you care about you can probably just ignore Y. Importantly this is true regardless of what X and Y are!

watched this on repeat losing my shit for two nights now

Love a paper with figures that make me ask questions like “When’s the last time I saw a hydrated binding pocket?” “When’s the last time I really *saw* a binding pocket?” “When’s the last time I really *saw* a *protein*?” “When’s the last time I really *saw* a PROTEIN, man?”