Really nice animation explaining how Orbitrap Astral technology works and serves humanity. Commisioned by the Royal Society of Chemistry for the Horizon Prize.

It's a great story. Lowering a FAIMS electrode temperature compromises resolving power and greatly increases transmitted peptide ions, while still filtering out troublesome singly charged background. www.nature.com/articles/s41...

I just had one last dinner with John Syka, before he moves back to Virginia for retirement later this week. I am indescribably grateful for the opportunity to work with him over the last eight years at Thermo. #TeamMassSpec (1/N)

There’s still time to share your analytical chemistry research at the Analytical research forum (ARF26). Oral abstract deadline is now 23 March. 📆 Submit your abstract today: rsc.li/arf2026 #ChemSky

MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10

Finally released the preprint covering TMT HR mode for the Orbitrap Astral Zoom mass spectrometer. Here, multi-pass MS/MS measurements grant us sufficient resolution to quantify TMT reporter ions even to 35-plex, greatly increasing analytical throughput. www.biorxiv.org/content/10.6...

Always enjoy a rare multi-reflection ToF publication. Fills in some gaps.

(JASMS) [ASAP] Faces of Mass Spectrometry/Khatereh Motamedchaboki: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00430 (RSS) #MassSpecRSS #JASMS

Big evaluation of our Orbitrap Astral Zoom mass spectrometer by the Olsen group, now peer reviewed, published and open access. www.sciencedirect.com/science/arti...

@benneely.com it’s finally real!!

Our Orbitrap Astral Zoom mass spectrometer has won its first prize! Nice little interview here with my teammate Johannes. theanalyticalscientist.com/issues/2025/...

Breaking barriers in crosslinking mass spectrometry with enhanced throughput and sensitivity using Orbitrap Astral www.nature.com/artic... --- #proteomics #prot-paper

I'm excited to see this paper in press! pubs.acs.org/doi/10.1021/...

🧵(4/7) 🔬 We have put together a fascinating #Keynote #Speakers team: • Prof. Albert Heck - @hecklab.bsky.social • Dr. Hamish Stewart - @hamishs.bsky.social • Prof. Olga Vitek - @olgavitek.bsky.social l • Prof. Ron M.A. Heeren

It is an honor to inform you that our manuscript with low resolution FAIMS is now online www.biorxiv.org/content/10.1...

👀 A simple optimization giving substantial benefits. A little like widening an over-tight quadrupole window to help transmission.

My great colleague Tabi is featured in JASMS. Check out his story.

🎉 BayBioMS turns 10! 🎉 2025 marks our 10th anniversary of Mapping Molecular Mountains. Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de! 🧵(1/6)

🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼 www.biorxiv.org/content/10.1...

Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀 Read how we did it in our latest paper 👇 pubs.acs.org/doi/10.1021/...

🎉 Today we reveal the 2025 RSC Prize winners! 🎉 Celebrating excellence across research, diversity, tech roles, apprentices and partnerships. Join us in congratulating the remarkable individuals and teams advancing chemistry for society. buff.ly/K2un4O1 #Chemistry #ChemSky

Orbitrap Astral Team receive the RSC 2025 Analytical Science Horizon Prize: Robert Boyle Prize. Interesting information about what each role does at TFS. A good read: www.rsc.org/standards-an...

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot. nationalmaglab.org/careers/meet...

Perfectly timed for the Orbitrap Astral Zoom launch today.

I am excited to share the first project of my PhD on bioRxiv and just in time for #ASMS2025 ! Increasing the sensitivity in single cell proteomics to quantify transcription factors in single hematopoietic stem and progenitor cells by iDIA. www.biorxiv.org/content/10.1...

The Cell Diversity Lab is well represented at this year's ASMS; please come and talk with Jakob Woessmann and Benjamin Furtwängler to hear all about their latest efforts in improving, and applying single-cell proteomics by MS. #singlecellproteomics #teammassspec #cellheterogeneity

A new dimension for multiplexing mass spec analysis -- time -- is enabling scaling up throughput at new levels. We demonstrate 27-plex DIA enabling over 500 samples / day. We project that timePlex will enable throughputs exceeding 1,000 samples / day. www.biorxiv.org/content/10.1...

News in Proteomics Research blog post | MAP-MS! Get more Orbitrap dynamic range for free! proteomicsnews.blogs... --- #proteomics #prot-other

Neil Kelleher: The Human Proteoform Project Could Transform Medicine theanalyticalscienti... --- #proteomics #prot-article

Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: www.hecklab.com/advanced-pro...

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm that deconvolves any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying analysis of bottom-up proteomics data. @msaid-de.bsky.social @kusterlab.bsky.social www.nature.com/articles/s41...

Nice reassuring thread on Astral uptime. Trends away from large injections and towards wider adoption of FAIMS are a boon.

Mass spectrometers appearing in the news, in this case the work of the Murdoch Children's Research Institute. www.foxnews.com/health/inter...

We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work

Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates. They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice. www.biorxiv.org/content/10.1...

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

Enlightening and accessible work from Josh Coon's group. It's good to see comparisons coming up. Wonder how many more Olink proteins would be shared with the deeper multi-fraction Seer/Astral analysis with 6k IDs.

New publication by Serrano et al. describes deep analysis of the human proteome in less than 1 hour! This paper describes the process and how it takes advantage of the new Orbitrap Astral mass spec high acquisition speeds. www.mcponline.org/article/S153...

With this manuscript we would like to demonstrate the incredible power of the Orbitrap Astral for XL-MS. Over 40% more IDs than the Orbitrap Eclipse! This opens up a completely new dimension for XL-MS. www.biorxiv.org/content/10.1...

Typing through gritted teeth.

My ceiling tiles are fantastic. The best. Hardly ever do workmen come in, lift the ceiling, and spray particulate crap into my instruments.