It is an honor to inform you that our manuscript with low resolution FAIMS is now online www.biorxiv.org/content/10.1...

👀 A simple optimization giving substantial benefits. A little like widening an over-tight quadrupole window to help transmission.

My great colleague Tabi is featured in JASMS. Check out his story.

🎉 BayBioMS turns 10! 🎉 2025 marks our 10th anniversary of Mapping Molecular Mountains. Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de! 🧵(1/6)

🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼 www.biorxiv.org/content/10.1...

Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀 Read how we did it in our latest paper 👇 pubs.acs.org/doi/10.1021/...

🎉 Today we reveal the 2025 RSC Prize winners! 🎉 Celebrating excellence across research, diversity, tech roles, apprentices and partnerships. Join us in congratulating the remarkable individuals and teams advancing chemistry for society. buff.ly/K2un4O1 #Chemistry #ChemSky

Orbitrap Astral Team receive the RSC 2025 Analytical Science Horizon Prize: Robert Boyle Prize. Interesting information about what each role does at TFS. A good read: www.rsc.org/standards-an...

RIP Alan Marshall, one of the greatest mass spectrometrists ever, and a great human to boot. nationalmaglab.org/careers/meet...

Perfectly timed for the Orbitrap Astral Zoom launch today.

I am excited to share the first project of my PhD on bioRxiv and just in time for #ASMS2025 ! Increasing the sensitivity in single cell proteomics to quantify transcription factors in single hematopoietic stem and progenitor cells by iDIA. www.biorxiv.org/content/10.1...

The Cell Diversity Lab is well represented at this year's ASMS; please come and talk with Jakob Woessmann and Benjamin Furtwängler to hear all about their latest efforts in improving, and applying single-cell proteomics by MS. #singlecellproteomics #teammassspec #cellheterogeneity

A new dimension for multiplexing mass spec analysis -- time -- is enabling scaling up throughput at new levels. We demonstrate 27-plex DIA enabling over 500 samples / day. We project that timePlex will enable throughputs exceeding 1,000 samples / day. www.biorxiv.org/content/10.1...

News in Proteomics Research blog post | MAP-MS! Get more Orbitrap dynamic range for free! proteomicsnews.blogs... --- #proteomics #prot-other

Neil Kelleher: The Human Proteoform Project Could Transform Medicine theanalyticalscienti... --- #proteomics #prot-article

Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: www.hecklab.com/advanced-pro...

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm that deconvolves any MS2 spectrum, regardless of whether it was acquired by DDA, DIA or PRM, thus unifying analysis of bottom-up proteomics data. @msaid-de.bsky.social @kusterlab.bsky.social www.nature.com/articles/s41...

Nice reassuring thread on Astral uptime. Trends away from large injections and towards wider adoption of FAIMS are a boon.

Mass spectrometers appearing in the news, in this case the work of the Murdoch Children's Research Institute. www.foxnews.com/health/inter...

We had built something conceptually similar using the front lens on an ICR (or adjacent quad segments) in a segmented PCB quad to trap ions between the LIT and ICR cell on our development instrument to improve trapping for short ICR array cells. Nightmarish to optimize timings, very impressive work

Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates. They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice. www.biorxiv.org/content/10.1...

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

Enlightening and accessible work from Josh Coon's group. It's good to see comparisons coming up. Wonder how many more Olink proteins would be shared with the deeper multi-fraction Seer/Astral analysis with 6k IDs.

New publication by Serrano et al. describes deep analysis of the human proteome in less than 1 hour! This paper describes the process and how it takes advantage of the new Orbitrap Astral mass spec high acquisition speeds. www.mcponline.org/article/S153...

With this manuscript we would like to demonstrate the incredible power of the Orbitrap Astral for XL-MS. Over 40% more IDs than the Orbitrap Eclipse! This opens up a completely new dimension for XL-MS. www.biorxiv.org/content/10.1...

Typing through gritted teeth.

My ceiling tiles are fantastic. The best. Hardly ever do workmen come in, lift the ceiling, and spray particulate crap into my instruments.