📣 Call for Papers! 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers

De Giorgis, Neely et al. show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to CaV1.2 channel opening upon the translocation of two charges before reaching full activation. rupress.org/jgp/article/... #IonChannels

Vonk, Esen, Kirby et al. @amsterdamumc.bsky.social report that 3D culture environments preserve #muscle fiber health and contractility better than 2D systems, offering an improved model for drug screening and testing genetic interventions. rupress.org/jgp/article/...

JGP's November issue is here! rupress.org/jgp/issue/15... In the retina of a Trpm1-knockout mouse, rod bipolar cell axon terminals (PKCα, green) are smaller and show an altered distribution relative to starburst amacrine cells (ChAT, magenta). From Horie et al. doi.org/10.1085/jgp....

⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference! Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org #WSCC26 #SodiumChannels #PainResearch

Altered Naᵥ1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction. new study from Noortje van den Braak, Maike Dohrn and colleagues @rwth.bsky.social: rupress.org/jgp/article/... #Pathophysiology #MolecularPhysiology #Nerve

The origins of oscillations. Horie et al. (doi.org/10.1085/jgp....) explain why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, & suggest that the same mechanism causes similar oscillations in other outer retinal diseases. In Research News: rupress.org/jgp/article/...

📣 Call for Papers! 📣 You are invited to submit your research on Voltage-Gated Sodium Channels. Submit your paper by September 30, 2026, to be highlighted in a special issue. Learn more 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

We’re thrilled to welcome the Journal of General Physiology @jgp.org @rupress.org to our Affiliate Program! 🎉 Authors can now seamlessly transfer their #peerreviewedpreprint @reviewcommons.org @embo.org to JGP via our transfer portal. Excited to start this new chapter with JGP @rupress.org!

🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome. 🧠 Abstracts due Nov 2 – all published in a JGP special issue! 🔗 sodiumchannelconference2026.org/WELCOME/

In two individuals w/ small fiber neuropathy carrying the p.(Tyr66Ser) variant in SCN11A, van den Braak, Dohrn et al. @rwth.bsky.social observed on/off-like axon hyperexcitability upon sine-wave stimulation, correlating w/ patch-clamp results of the Naᵥ1.9 channel variant rupress.org/jgp/article/...

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. New study from Sho Horie, Katsunori Kitano, Masao Tachibana, Chieko Koike and colleagues (Ritsumeikan University): rupress.org/jgp/article/... #Neuroscience #Pathophysiology #CellularPhysiology

Latest in Research News: new study from Horie et al. (doi.org/10.1085/jgp....) explains why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, and suggests that the same mechanism causes similar oscillations in other outer retinal diseases. rupress.org/jgp/article/...

#SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1, say Aishwarya Chandrashekar, Leigh Plant and colleagues @nubouve.bsky.social: rupress.org/jgp/article/... #Pathophysiology #IonChannels #SignalTransduction #CellularPhysiology #MolecularPhysiology

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community. Hugues Abriel and Angelika Lampert (@lampertlab.bsky.social) introduce the Special Issue (rupress.org/jgp/search-r...) illustrating the richness and continuing momentum of this field. rupress.org/jgp/article/...

Horie, Kitano, Tachibana, Koike et al. show that TRPM1 deficiency in ON bipolar cells produces retinal ganglion cell oscillations in association with rod bipolar cell axon remodeling and reduced ON bipolar cell outputs rupress.org/jgp/article/... #Neuroscience

📣 #CallForPapers Reminder on the topic of SGP's (@sgpweb.bsky.social) 2025 Symposium “Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) Deadline: December 15. Learn more and submit your research. 👉 rupress.org/JGP/pages/ca...

Chandrashekar, Plant et al. @nubouve.bsky.social shows that #hypoxia-induced #SUMOylation and the Andersen-Tawil syndrome type 1-linked Kir2.1 mutation, R67Q, converge to impair channel function by destabilizing interactions with PIP₂. rupress.org/jgp/article/... #IonChannels

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice. A new study from Rosa Scala, Colin Nichols et al. @colinnicholslab.bsky.social rupress.org/jgp/article/... #IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle

Cortical spreading depression dynamics are altered by topical D2 receptor ligands, say Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, and Rubem Carlos Araújo Guedes rupress.org/jgp/article/... #Neuroscience #ComputationalBiology #MolecularPharmacology #SystemsPhysiology

This Special Issue rupress.org/jgp/search-r... brings together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, & structure-function analysis of voltage-gated sodium channels. Editorial by Abriel & @lampertlab.bsky.social: rupress.org/jgp/article/...

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/... @colinnicholslab.bsky.social #IonChannels #Phospholipids

A reminder to join us for the SGP Cranefield Award Talks, taking place tomorrow, 8 October, from 12:00 pm to 1:30 pm Eastern. Register (no fee) at bit.ly/sgp2025crane....

Check out our new publication "PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating" 🧪 A 🧵 1/n

Check out our new publication "Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice" 🧪 @rosca26.bsky.social A 🧵 1/n

Scala et al. @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles showed enhanced fatiguing that was reversed by the KATP channel inhibitor glibenclamide.

Scala et al. @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles showed enhanced fatiguing that was reversed by the KATP inhibitor glibenclamide.

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, and Rubem Carlos Araújo Guedes reveal that dopaminergic signaling influences cortical excitability and cortical spreading depression dynamics, offering new mechanistic insights into dopamine’s cortical role.

Want to learn more about the amazing work of our ⭐️2025 SGP #CranefieldAwards⭐️recipients @huanghe-lab.bsky.social and Man Si, published in @jgp.org? 👏Join us online on🗓️ Wednesday, 8 October, at ⏲️ 12:00 pm Eastern! Register🆓👉http://bit.ly/sgp2025cranefield.

Eva-Maria Zangerl-Plessl, Sun-Joo Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/... @colinnicholslab.bsky.social

We’re thrilled to welcome Teresa Giraldez (@giraldezt.bsky.social) from @itb-ull.bsky.social @ull.es to the JGP editorial team! Prof. Giraldez brings a wealth of knowledge on ion channels, signaling nanodomains, and neurological diseases 🙌 Read the full announcement: rupress.org/jgp/pages/gi...

For #PeerReviewWeek's AI focus, we want to take a moment to thank the people behind the peer review process. Our position is that rigorous peer review demands direct accountability that only human reviewers can provide. Thank you for all that you do!

#CallForPapers 📣 We're accepting submissions on the topic of @sgpweb.bsky.social's 2025 Meeting "Tracing the Path of Chloride: from Ion Channels and Transporters to Physiology & Therapeutics” (www.sgp2025.com) – with Guest Editors Anne Carlson and Zhaozhu Qiu! 👉 rupress.org/JGP/pages/ca...

NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/... #Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels

Investigating the Role of the I–II Linker in Nav1.5 Channel Function. New study from Emily Wagner, Jonathan Silva and colleagues @washuengineers.bsky.social: rupress.org/jgp/article/... #Biophysics #Pathophysiology #IonChannels

ICYMI: JGP 2025 Highlights Collection provides new insights into the mechanism of fast inactivation of voltage-gated sodium channels, the stoichiometry of pannexin channels, the modulation of ion channel properties by glycosylation and toxins, and more 👉 rupress.org/jgp/collecti... #SGP2025

What happened to the pursuit of truth? Eve Marder discusses a recent Viewpoint (rupress.org/jgp/article/... ) on the advent of #AI #LLM and their indiscriminate use to speed up the production of papers. rupress.org/jgp/article/... 📙 In JGP Highlights collection 2025: rupress.org/jgp/collecti...

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers. From Smriti Gupta, Douglas Bayliss and colleagues: rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/... #Evolution #IonChannels

PANX1 hexamers work but cells prefer heptamers. Andrew Harris provides commentary on work from Gupta et al. (rupress.org/jgp/article/...): rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Yichen Liu and Francisco Bezanilla show that a sodium channel mutant removes fast inactivation with the inactivation particle bound rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Hi1a reduces ischemic cell death by inhibiting ASIC1a channels. Berger & MacLean show each domain of Hi1a binds to the same site on ASIC1a subunits, accounting for this peptide’s unusual functional effects rupress.org/jgp/article/... 📙 JGP Highlights Collection 2025: rupress.org/jgp/collecti...

Wagner, Silva et al. @washuengineers.bsky.social show that deleting large sections of the Nav1.5 I–II linker does not affect voltage-dependent gating. But changes to the protein sequence does affect gating, showing how certain variants can alter channel function. rupress.org/jgp/article/...

Beaudoin, Jackson et al. investigate the structural effects of N-linked glycosylation on Naᵥ channels using molecular modeling and dynamics simulations. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Resolving zone-specific regulation of cardiac #myosin. Shane Nelson @uvmvermont.bsky.social provides commentary on work from Pilagov et al. (rupress.org/jgp/article/...) that explores role of MyBP-C in regulation of the myosin SRX state in cardiac muscle. rupress.org/jgp/article/... #Myofilaments

In this Viewpoint, Hull and @lampertlab.bsky.social explore the role of metaphors in the sodium channel fast inactivation mechanism-accessible to readers without a linguistics background. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Mercado-Perez, Beyder et al. show that some Piezo2 clusters in these cells interact with E-cadherin and #actin #cytoskeleton at the lateral wall. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

França & Monserrat discuss how large language models are likely to amplify the worst incentives of academia, greatly increasing the volume of scientific literature while diluting its quality. rupress.org/jgp/article/... 📙 In JGP Highlights Collection 2025: rupress.org/jgp/collecti... #SGP2025

Skeletal muscle gets some help down the stretch. Woods et al. (rupress.org/jgp/article/...) suggest that stretch activation is important in fatigued skeletal muscle when stretch-activated tension persists even as Ca2+-activated force production declines. In Research News: rupress.org/jgp/article/...

We’re pleased to present a special collection highlighting some of the most read and discussed papers published over the past 12 months. Gain new insights to accompany the 2025 Meeting of the Society for General Physiologists (@sgpweb.bsky.social) #SGP2025 👉 rupress.org/jgp/collecti...