Check out our latest review "From Selective Permeation to Physiology in Potassium Channels" 🧪 journals.physiology.org/doi/full/10....

Check out our new publication "Cantu syndrome–associated SUR2[H60Y] mutation confers selective gain of function on Kir6.1 ATP-sensitive potassium channels" 🧪 www.jbc.org/article/S002... A 🧵 1/n

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice. A new study from Rosa Scala, Colin Nichols et al. @colinnicholslab.bsky.social rupress.org/jgp/article/... #IonChannels #MolecularPhysiology #Pathophysiology #SkeletalMuscle

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/... @colinnicholslab.bsky.social #IonChannels #Phospholipids

Check out our new publication "Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cantú syndrome" 🧪 @nature.com www.nature.com/articles/s41...

Check out our new publication "Molecular basis of TRPV3 channel blockade by intracellular polyamines" 🧪 www.nature.com/articles/s42...

In @jgp.org, Scala et al @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles show enhanced fatiguing that was reversed by the KATP inhibitor glibenclamide

Check out our new publication "Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice" 🧪 @rosca26.bsky.social A 🧵 1/n

New in @jgp.org: Zangerl-Plessl, Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/... @colinnicholslab.bsky.social

Check out our new publication "PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating" 🧪 A 🧵 1/n

We love it Stephen, thank you! 🧪

Check out our new publication "Paradoxical Maturity-Onset Diabetes of the Young Arising From Loss-of-Function Mutations in ATP-Sensitive Potassium Channels" 🧪 diabetesjournals.org/diabetes/art... @rosca26.bsky.social A 🧵 1/n

Next Monday! 🧪

Join us today for a new exciting CIMED seminar! 🧪 @osamaharraz.bsky.social

Join us today for a new exciting CIMED seminar! 🧪

🧪

Check out our new publication "Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels" www.sciencedirect.com/science/arti... A 🧵 1/n

Join us today for a new exciting CIMED seminar! 🧪

Join us today for a new exciting CIMED seminar!

📢 Nichols Lab is hiring! 📢 Join us at WashU & contribute to cutting-edge ion channel research. DM or email nicholslab.wustl.edu

Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" A 🧵 1 journals.sagepub.com/doi/10.1177/...