Check out this great review by Osama Harraz et al., Brain Capillary Ion Channels: Physiology and Channelopathies ➡️ https://ow.ly/Jenc50YCOSA #BrainCapillaries #IonChannels

Very hot from the press ! Almost every topic we work in: #IonChannels #Leukocytes #CalciumSignaling T cell response depends on target-cell stifness to drive Piezo1- Orai1 membrane channels activation, softening of tumours prevents this response. Full www.science.org/doi/10.1126/... @science.org

Activation of the Piezo1 ion channel in a mouse model of Alzheimer's disease restored brain blood flow and improved neurovascular function, suggesting potential for future therapeutic strategies. doi.org/hbnvgf

Very excited to share our new manuscript – published today! Why are PIEZO1 and PIEZO2 are tuned to transduce different types of mechanical force? I was lucky to work with some extraordinary colleagues to begin to figure out why. www.nature.com/articles/s41... An overview of the results below ⬇️ ⬇️

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

I am delighted to host Dr. Stephen Liberles @harvardmed.bsky.social @hhmi-science.bsky.social as he presents the Pharmacology Department Seminar today April 9th at the @uvmlarnermed.bsky.social @uvmvermont.bsky.social “Mechanisms of body-brain communication”

Mesmerizing 🧠!

This recent study by Bianca Barreira of @ucm.es et al. investigates functional expression of inwardly rectifying and ATP-sensitive #potassium channels in human #pulmonary artery smooth muscle and endothelial cells 🔬 🫀 📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Check out this review on brain 🧠capillary ion channels in health and disease… a topic that has evolved (and continues to grow) dramatically over the past decade.🗓️📅

Please join us on February 24th for our next installment of the graduate students' CMB seminar! There will be excellent talks and discussions!! @devdoot.bsky.social @uvmcmb.bsky.social @msymeonides.bsky.social @karenglasslab.bsky.social @wargolab.bsky.social @osamaharraz.bsky.social

PIP2 corrects an endothelial Piezo1 channelopathy | PNAS www.pnas.org/doi/10.1073/...

🧠🆕Review article: "Brain Capillary Ion Channels: Physiology and Channelopathies." Osama F. Harraz and Ahmed M. Hashad https://ow.ly/MUCH50YbM0p. #BrainCapillaries #CerebralBloodFlow

📣 #CallForPapers 📣 on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on Ion Channels in Health & Disease” – w/ Guest Editors Jelena Baranovic, @osamaharraz.bsky.social, Conor McClenaghan, & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

📣 #CallForPapers 📣 Submit your research on the topic of the inaugural in-person Electrophysiology & Ion Channel (EpIC) meeting, “Emerging Research on #IonChannels in Health & Disease” – w/ Guest Editors Jelena Baranovic, Osama Harraz, Conor McClenaghan & Lejla Zubcevic 👉 rupress.org/JGP/pages/ca...

Leukocyte stalling in 🐭Retinal microvasculature 2PM In 20 s, "~7% tracked leukocytes stalled for at least one time along their path", up to 9 stalls 87% stalls occur at vessel junctions, where 71% occupied with #Pericyte ⏫RBC flow irregularity #JCBFM 2025 journals.sagepub.com/doi/10.1177/...

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My Name is Doddie Foundation Catalyst Awards 2026 are now open. Funding bold early stage MND research ideas with up to £100k to generate data and open new treatment pathways. www.dementiaresearcher.nihr.ac.uk/funding/my-n...

🎉 New Publication in @pnas.org Excited to share our lab’s latest research article: PIP₂ Corrects an Endothelial Piezo1 Channelopathy pnas.org/doi/abs/10.1... (Open Access)

Restoring levels of the phospholipid PIP₂ may help normalize brain blood flow and reduce symptoms in vascular dementia by regulating the activity of the Piezo1 protein.

When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

Grateful to @pewtrusts.org for funding our snow fly work, in collaboration with Sebastian Brauchi at Universidad Austral de Chile. We are now looking for post-docs to work on the biophysical mechanisms that allow snow fly neurons and muscles to function below zero. newsroom.uw.edu/news-release...

🧵Excited to share our work with the Bracko @bloodflowlab.bsky.social lab published in Alzheimer's & Dementia @alzassociation.bsky.social : Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease 🔗https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71016

#UVMLarnerMed research publication alert! #Brainresearch by authors Osama Harraz, Ph.D., and Ahmed Hashad, Ph.D., Department of Pharmacology, Larner College of Medicine, Vermont Center for Cardiovascular and Brain Health. @uvmvermont.bsky.social @apspublications.bsky.social

Excited to share the latest from our lab (final version, open access): Brain Capillary Ion Channels: Physiology and Channelopathies Physiology | @apspublications.bsky.social journals.physiology.org/doi/full/10.... @uvmlarnermed.bsky.social

Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6

The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

This is sad, to say the least...

I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!

Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!

Last week at the Dean’s Celebration of Excellence in Research, the annual #UVMLarnerMed Research Rally showcased inspiring research by faculty scientists. Learn more about #larnerresearch at go.uvm.edu/lcomresearch #medicalresearch #research @uvmvermont.bsky.social @osamaharraz.bsky.social

Received a Dean’s excellence in research award and I’m pretty chuffed about it. Thanks to friends, family and colleagues who keep me going.

Today, UVM President Marlene Tromp announced that the University of Vermont has named Richard L. Page, M.D., Dean of the Larner College of Medicine, as its inaugural Chief Medical Affairs Officer. Read more: go.uvm.edu/medaffairs @uvmvermont.bsky.social photo: Andy Duback

✨VERY EXCITED to share groundbreaking research by Luyue Zhang, Ana M. Franceschi, John Crary, Frank Provenzano✨Here, they suggest a previously unrecognized biomechanical contribution to initiation of tau pathology in aging & sporadic AD. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

We are delighted to welcome Caroline Kehlet to our lab. Caroline is an undergraduate student at UVM double majoring in Anthropology and Neuroscience. Welcome Caroline!

Membrane Biology: Nothing can replace polyunsaturated lipids Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane. buff.ly/qcLJNUN

The lab crew!

#FluorescenceFriday NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye doi.org/10.7554/eLif... @flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social

Thrilled to share this amazing work from Marie Blanchette & team in the Daneman Lab!!! We found that differences in the BBB across brain regions help regulate local brain function 🧠 Honored to have contributed to the study & to have had Marie as a mentor during my PhD💕 www.nature.com/articles/s41...

This is amazing. And it's not just math talent: she is a mature communicator now. She blossomed when moving from homeschooling to math communities in Chicago and at Berkeley. This is a story that should inspire us. 🧪

Delighted to share our latest review in Nature Reviews Neuroscience! We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies. www.nature.com/articles/s41...

We are excited to report: Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice Vittani et al. PNAS (2025) pnas.org/doi/10.1073/...

📰Latest from our lab (Open Access)! Brain Capillary Ion Channels: Physiology and Channelopathies This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries @apspublications.bsky.social journals.physiology.org/doi/abs/10.1...

Would you like to participate in the peer review process at Communications Biology? Please fill out this form to express your interest to act as a reviewer📝 We particularly encourage early-career researchers and applicants from underrepresented groups in research. forms.office.com/e/fv22f9aRt5

Don't miss this ⭐EpIC⭐ seminar TOMORROW! Dr. Olivier Romito (Trebak Lab) will present on endothelial Orai1 channels and their role in leukocyte adhesion. If you are not registered and interested, please register (sgp-epic-seminars.com) @sgpweb.bsky.social @lejlazubcevic.bsky.social

Interested in a neuroscience PhD or postdoc position in Germany? Check out the Brain Algorithms and Circuits Group opening at MPI this Fall!! And many congrats to my friend Gregor Schuhknecht on opening his lab 🥳 #Neuroscience #Zebrafish #NeuroJobs brain.mpg.de/schuhknecht

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

That's how I like to start the summer! Our story identifying decorin as a novel player in cardiovascular ageing just got published in #CardiovascularResearch 💃🏻💃🏻 Congratulations to all authors and thanks to @ekfstiftung.bsky.social that made this study possible academic.oup.com/cardiovascre...

It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩

Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium