Join @cmaley.bsky.social, @lucielaplane.bsky.social, Joel Brown and Benjamin Spada for a live EvoChat discussion about "How we define cancer matters", hosted by the International Society for Evolution, Ecology and Cancer (ISEEC). Oct 1st at 8am PST, 11am EST, 5pm CEST ucsb.zoom.us/j/8313111375...

This is a disaster if the EU doesn't follow up by doubling the budget 😬🧪

The scent of silence! Cool research in Cell @cellpress.bsky.social to brighten up your day🌹. The mystery of why some roses are fragrant and others aren't has an answer. It's called SCREP: a rose-specific gene that evolved from non-coding DNA 16.8 million years ago 👇

Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

Domain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13

simply wonderful science 🤩

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

📢 We are recruiting! Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies. Please share and RT 🙏

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

Once a surfer's paradise, a string of deadly attacks made Réunion Island synonymous with one word only: sharks. But a team of scientists turned this tiny island into a hub of lifesaving research. For @science.org, I wrote about this fascinating place. www.science.org/content/arti...

Happy to share our recent publication on benchmarking peak calling methods for CUT&RUN. academic.oup.com/bioinformati... Published in @oxunipress.bsky.social Bioinformatics | led by aminnoorani.bsky.social #Epigenomics #Genomics #Bioinformatics #MachineLearning #CUTandRUN #CompBio #4DNucleome

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...

Why choose the Vienna BioCenter - Hear it directly from our fellows! The VIP³ call is open – 16 fully-funded, three-year postdoctoral fellowships in an interdisciplinary environment: training.vbc.ac.at/post-docs/vi... #VBCPostDoc

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

🎉 Congrats to our scientists at The Scotland Institute on their publication in the Journal of Medicinal Chemistry! They’ve developed reversible Ras inhibitors with tunable affinity for active & inactive forms, a big step in #DrugDiscovery. More: tinyurl.com/y45t4yy7 #OnMyHorizon @acs.org

Nice work from Du & Warmflash using micropatterned hESCs to dissect midbrain-hindbrain boundary formation Timing of WNT signalling, not strength or duration, specifies midbrain-hindbrain boundary Good example of recapitulating developmental signalling in vitro www.biorxiv.org/content/10.1...

We are highlighting Pleasantine Mill, 2025 @bsdb.bsky.social Wolpert Medal winner, as an extraordinary biologist this week. Pleasantine is also coordinating a @jcellsci.bsky.social Special Issue and co-organised the 2024 @dmmjournal.bsky.social‬ Journal Meeting. #100biologists @cilialab.bsky.social

Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish www.biorxiv.org/content/10.1... #sarcoma

Under pressure archaea develop tissue-like multicellularity! Fascinating! 👉🏻https://www.science.org/doi/10.1126/science.adu0047

This morning, at #ASCO25 in Chicago, Professor Robin Jones presents an oral session on advanced #Sarcoma ⬇️ meetings.asco.org/abstracts-pr...

Thanks to phenomenal work by @crg.eu and @irbbarcelona.org press offices, we got to communicate our findings on 🧬 methylation barcodes and 🩸 blood ageing to a wide audience. A cool experience! 🧵 with highlights in 5 languages and funny moments 😬😅 cadenaser.com/nacional/202... (1/n)

We were up and shining up on the stage at the “Impact Festival” yesterday 🐟🐟🐟🎉🎉🎉🤩🤩 Thank you for the nomination 🥰 Go Fish !

Expansion microscopy 🤩

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social. pubmed.ncbi.nlm.nih.gov/40436628/

I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com! 🔗 tinyurl.com/3jkzzy7d

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

Excited our paper is out in Cell @cp-cell.bsky.social! 🧬⚡ DNA photo-crosslinking proteomics in living cells 🎯 Pinpoints protein-DNA interactions to single amino acids 🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes 🔗 www.cell.com/cell/fulltex... 🧵

Cell cycle duration determines oncogenic transformation capacity Tumours usually originate from a specific cell type in a given tissue; cell types that have faster cycles are more likely to become cancerous 🧪 www.nature.com/articles/s41...

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics

To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...

📣 A reminder about an open postdoctoral position in our group! 🧫 Are you interested in mechanisms of gene regulation, human facial development and disease? How our DNA shapes the way we look? Do you love chromatin and enhancers? 🧬 If so, reach out for an informal chat! 💬 longlab.co.uk

Hey #HemeSky and #EpiSci folks! We are hiring! For our Translational Cancer Epigenomics team @dkfz.bsky.social and @nct-heidelberg.bsky.social we are looking for a talented postdoc interested in research on heme malignancies and #epigenetics. Interested? 👉See jobs.dkfz.de/en/jobs/1676... or DM me!

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

We were delighted to welcome @drscottarthurmp.bsky.social to IGC today where he met Neil Carragher, as well as @nsbenab.bsky.social and Val Brunton, to learn about research into rare cancers as part of his work on the #RareCancersBill: bills.parliament.uk/bills/3779 @cmvm-edinburghuni.bsky.social

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

🚨Our new prepint 🚨 ▶️ When a bromodomain goes rogue Rsc1 bromodomain 2 doesn’t bind acetyl-lysines. It grabs DNA instead — and yeast cells die 💀 without it. Plot twist? Read our preprint: 👉 www.biorxiv.org/content/10.1... #chromatin #bromodrama #DNAlover And a 🧵👇 1/5

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

Interested in rare models?🦇 Looking to diversify your research options? An EMBO workshop (9-13 June) led by IRR scientists is exploring how unconventional vertebrate models are becoming engines for new research directions in biomedicine. Find out more and register: edin.ac/4iLmGjW

4ème cours demain vendredi 10h sur la régulation génétique par les séquences enhancers @collegedefrance.bsky.social. Ortaugraf, sintax et gramère 😬 Sortie libre.

NCBI websites are patchy at present, but now feel far less secure for long-term storage than they used to. For sequencing datasets consider using ArrayExpress: www.ebi.ac.uk/biostudies/a... Many, if not all, GEO datasets are on there.

Haven't registered your place for the Beatson International Cancer Conference 2025 yet? Find out what delegates had to say about last year's event 📅Register by 21 March: beatsonconference.org #BICC2025

Paper is out! Great team effort led by Dominika Grzejda and Anton Heß @antonhess.bsky.social

Multiple zebrafish-adjacent projects with some outstanding #WomenInScience (see separate openings from @kaguelab.bsky.social 🖥️ 🦴 or @hannahlong.bsky.social 🧫 ) More details here: institute-genetics-cancer.ed.ac.uk/igc-graduate...

We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

Really delighted to show our first attempts at growing Wilms Tumour organoids (left) and the kidney (right) from paediatric patients by @maxpedsurg.bsky.social ,Zeynep Kaya and Kaitlin Marley. Funding from @littleprincesses.bsky.social Project here: www.littleprincesses.org.uk/news/innovat...