If you are curious about how cohesin regulates chromosome contact dynamics and its role in enhancer-promoter communication, check out our latest work. It’s been really fun to work with @nesslfy.bsky.social and @lucagiorgetti.bsky.social. Hope you enjoy reading it!

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

We're excited to share our new preprint, "Joint decomposition of Hi-C maps reveals salient features of genome architecture across tissues and development", led by Thomas Reimonn. www.biorxiv.org/content/10.1...

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

following this week's JC - this latest preprint from Giorgetti lab is *extremely* intriguing! TLDR: enhancers wake up promoters from their rare-bursting sleep and put them into a frequent-bursting state. The timescale is surprising - an Enh 150kb away activates the gene once a day!!

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬 www.biorxiv.org/content/10.1...

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function. Deadline July 15th. www.mdc-berlin.de/career/jobs/...

I'm proud to announce the latest release of 🧬 #Oxbow 🏹, with new features to make NGS data analysis more powerful, efficient, and "composable". Learn more at: oxbow.readthedocs.io

We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested. www.fmi.ch/education-ca...

Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

We're hiring a postdoc! Come join my lab @Novartis Oncology in Basel 🇨🇭, and employ genome engineering and functional genomics approaches to study how oncogenic Transcription Factors function at the molecular level (and how to drug them) 3+1 years! Apply! Please RP www.novartis.com/careers/care...

Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social. pubmed.ncbi.nlm.nih.gov/40436628/

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May: www.findaphd.com/phds/project... Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social). Please share 🙏 #epigenetics

📣 A reminder about an open postdoctoral position in our group! 🧫 Are you interested in mechanisms of gene regulation, human facial development and disease? How our DNA shapes the way we look? Do you love chromatin and enhancers? 🧬 If so, reach out for an informal chat! 💬 longlab.co.uk

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

What happens if an expression construct has strong predicted splice donor sites inside the ORF? Would removing them increase protein expression?

Three-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it: doi.org/10.1093/nar/...

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

Help us decide! Where would it be easier for you to come and chat to us about using or contributing to Open2C software?

Hi all! Moved over from X/Twitter, looking forward to sharing our news and updates with everyone here!

Couldn't agree more with Paul Nurse that “Research institutes and units play a unique, beneficial role in the UK’s RDI landscape and this sector should be expanded....” So the MRC should rethink their regressive decision to close MRC Units. www.science.org/content/arti...

Last chance to apply for the 2025 edition of the Sci.STEPS program! Don't miss your opportunity to get career advice and guidance from one of our experienced mentors.

The deadline to apply to the Sci.STEPS program is approaching! Apply asap if you need help navigating your career in science.

We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.

Navigating your PhD? Sci.STEPS connects you with experienced peers who've navigated these waters before. From career paths to research challenges, having someone to talk to makes the difference. Join Sci.STEPS and set your course! Apply now 🧭✨

After a month of hard work to create a pool of over 50 fantastic mentors, we have opened the call for mentee applications! If you are an early career researcher and need help navigating the career path (be it academia or industry, or anything else), see if there is a mentor for you and apply!

Last day to apply as a mentor to the Sci.STEPS program! @academic-chatter.bsky.social #mentoring #science

🌟 if you're thinking about becoming a #mentor but unsure: Your unique experiences can guide and #inspire others! 💙 It might be intimidating to label oneself a "mentor", but mentoring is about sharing your journey, not having all the answers, and you can help at any stage of your #ScientificCareer

💡Language: The official language is English, but please specify additional languages you are comfortable mentoring in! Learn more about the call: scisteps.org/call-2025 Join us to make an impact on the next generation of scientists and enhance your own professional network 🌿

Program Details: 💡Duration: February to the end of April 2025 💡Commitment: Approximately 2 hours biweekly 💡Activities: Educational content, workshops, and personalized advising sessions with paired mentees based on your availability

🚀Join Us for the Season 2025 as a #Mentor! We are looking for mentors from diverse paths and stages of their #scientific careers to guide and inspire our #mentees. Want to become a mentor? ✏️Register here: tinyurl.com/sciSTEPS2025 🗓 Deadline: 17.11.2024

Now for a science question. Does anyone know of an alternative to ERT2/tamoxifen for tight control of protein activity (e.g. recombinase) in tissue culture cells? Tetracycin promoter could work for inducible transcription, but requires to express an extra protein, so less convenient.

For my first real post here, I want to advertise Sci.STEPS - an international mentoring program for scientists I am co-organizing. We are recruiting mentors right now! Check it out and join us for the next season. www.scisteps.org/call-2025 We welcome anyone related to science in any shape or form!

Hello, world! This place looks promising now! 😃