Aleksandra Galitsyna
@agalicina.bsky.social
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PhD 路 scientist @ MIT 路 curious human being
https://aleksandra-galitsyna.com/
reposted by
Aleksandra Galitsyna
Nick Adams
9 days ago
Why are pDCs so good at producing type I interferons? We set out to address this long unanswered question in our
@cp-immunity.bsky.social
study. A great collaboration between the Reizis Lab @NYU
@uchicagocoi.bsky.social
and
@agalicina.bsky.social
& Leonid Mirny @MIT 1/
www.cell.com/immunity/ful...
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Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells
Powerful interferon (IFN)-I-producing capacity distinguishes plasmacytoid dendritic cells (pDCs) from related innate cells. Adams et al. find that, during pDC development, the locus encoding IFN-I gen...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00561-8
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One of the first in vivo demonstrations that cohesin loss in non-dividing cells can hit hard physiologically, impairing immune function of dendritic cells in mouse. Out in Science Immunology, major contributors:
@nickadams-phd.bsky.social
, Boris Reizis, Leonid Mirny
www.science.org/doi/10.1126/...
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Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells
Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.
https://www.science.org/doi/10.1126/sciimmunol.adx4622
10 days ago
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reposted by
Aleksandra Galitsyna
Nick Adams
12 days ago
Excited to share our work published yesterday (and featured on the cover!) of
#ScienceImmunology
. This was a true team effort between the Reizis lab at NYU
@uchicagocoi.bsky.social
and Sasha Galitsyna & Leonid Mirny at MIT 1/
www.science.org/doi/10.1126/...
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reposted by
Aleksandra Galitsyna
Job Dekker
16 days ago
Terrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains
add a skeleton here at some point
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Have you wondered how the rules of chromatin folding have evolved? Well, this task is not easy to formalize. But here is our take on it: train species-specific DNA-to-chromatin encoder, apply to DNA of unseen species, and build chromatin rules-based tree of life. Have a look:
doi.org/10.1093/nar/...
24 days ago
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Three-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it:
doi.org/10.1093/nar/...
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Convergent pairs of highly transcribed genes restrict chromatin looping in Dictyostelium discoideum
Abstract. Dictyostelium discoideum is a unicellular slime mold, developing into a multicellular fruiting body upon starvation. Development is accompanied b
https://doi.org/10.1093/nar/gkaf006
about 1 year ago
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