We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n

new out in Nature www.nature.com/articles/s41...

🚨 Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease? Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city. 🧵 1/4 Please repost 🙏

Thrilled to announce that I'm on Curious Cases tomorrow at 10am on BBC Radio 4! The episode - Immortal Jellies - looks at some remarkably long-lived species and what they can teach us about ageing. This is a key area of focus for our lab. www.bbc.co.uk/sounds/play/...

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Come to Germany and do a PhD with DKFZ. You'll be supported by an international community doing amazing science in a fantastic place. I joined the DKTK from the UK 3 months ago and couldn't be happier with how easy it has been fitting in. The quality of work here is phenomenal and you should apply!

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

Single cell whole genome and transcriptome sequencing links somatic mutations to cell identity and ancestry https://www.biorxiv.org/content/10.1101/2025.10.28.685157v1

Our latest collaboration with the talented Susi @sbantele.bsky.social and Jiri Lukas is out now @science.org 🤩. We reveal the hidden price for DNA repair, with potential implications for genome function, gene therapy and ageing👇

Explore the origins, patterns and consequences of mutations across biological systems! #MITS26 🗓️ Conference dates: 13-15 April 2026 Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬 Check out our exciting speakers ➡️ bit.ly/4hmbnyr#MITS26#Genomics

New preprint from another part of my PhD! 📝👇 Some mutations arise after fertilisation 🧬, so early they can appear in both a parent’s body and their germ cells. By analysing family trio genomes 👪, we built one of the largest catalogues of these “hidden” inherited variants yet. tinyurl.com/mvns2ytv

Mutations in Time and Space is headed to Cambridge, UK for 2026! You can check out the exciting list of invited speakers here: coursesandconferences.wellcomeconnectingscience.org/event/mutati... See you at the Wellcome Genome Campus, on 13–15 April? Nice one! ;-) #MITS26

Awesome @naxerova.bsky.social !!!!! It's been a bumper week for super cool cancer genetics papers!!

Now published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...

Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41... If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS @cancergrand.bsky.social @cmvm-edinburghuni.bsky.social

📢OUT @natgenet.nature.com 📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution. By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues. ⬇️ www.nature.com/articles/s41...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease. Explore the science behind it: www.biorxiv.org/content/10.1...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

New paper out today in @science.org! Very proud that my team was able to contribute to this fantastic work from @bethpsaila.bsky.social's group. In short: platelets contain a fair amount of cfDNA taken up from the surrounding! Read the summary by lead author @l-cmurphy.bsky.social:

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679... You'll learn a lot and it'll be fun and interesting! #DKTK @dkfz.bsky.social @lmumuenchen.bsky.social

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

new out in Nature yesterday www.nature.com/articles/s41...

Dive into the step-by-step choreography of transcription-coupled DNA repair. In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research! www.nature.com/articles/s41...

🚨 Looking for postdocs! I'm starting my lab at UT Southwestern this September. If you're interested in: 🧬 Somatic & germline mutagenesis 🐭 Evolution of mutation processes 🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining. Formal ad coming soon. DM me!

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. 👉 Early cancer detection 👉 Methylation drivers 👉 Epimutation rates 👉 CpG lineage tracing www.biorxiv.org/content/10.1...

Last but not least, if you're interested in somatic mutations, new technologies and computational genomics - we're hiring a postdoc in my brand new lab @emblebi.bsky.social! Reach out if interested or you have any questions, and apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

new out in Nature this week www.nature.com/articles/s41...

We’re hiring! Postdoc in Computational Genomics at @uoe-igc.bsky.social Focus: myeloma, structural variants, heterochromatin, multiomics Deadline: 9 July 2025, 23:59 GMT Apply: elxw.fa.em3.oraclecloud.com/hcmUI/Candid... #myeloma #postdoc #genomics #bioinformatics #epigenetics #codeandkilts

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...

If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...

Social media grump Kamila has finally made it onto Bluesky! Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news. I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.

We are hiring! Want to join my new group at the amazing @uoe-igc.bsky.social and perform ground-breaking studies in reproductive genomics and genomic medicine as a computational genomicist? Please DM me to discuss this, I will be attending #ESHG2025 elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy Published @natcancer.nature.com Melissa is an outstanding new clinician scientist.. one to watch. www.nature.com/articles/s43... @icr.ac.uk

🚨New preprint!🚨 Venturing out of the nuclear genome to explore #mtDNA: "Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis" www.biorxiv.org/content/10.1... Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️

With the brilliant @mlockley.bsky.social we've been exploring chemo resistance evolution in ovarian cancer. We find resistance has a fitness cost which means resistant cells are outcompeted by sensitive cells when treatment is stopped. aacrjournals.org/cancerres/ar... @icr.ac.uk @qmbci.bsky.social

Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1... #Genomics #SomaticEvolution

I had an incredible time at the Mutations in Time and Space conference last week! There were a ton of interesting talks and I so appreciate the engagement with my work. Excited for more! #MITS25

Proud to have Prof Nicky McGranahan #CRUKFunded who co-lead City of London Centre Cancer Evolution theme charing and speaking about immunology and somatic evolution at #AACR25!

If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...

New online! Advances in single-cell DNA sequencing enable insights into human somatic mosaicism