Congratulations to Martin Taylor for being shortlisted in this year’s #CancerGrandChallenges! The CAUSE team will now compete for the chance to receive up to £20m to make radical progress against cancer’s toughest challenges: bit.ly/41KM1DS @cancergrand.bsky.social @cmvm-edinburghuni.bsky.social

📢OUT @natgenet.nature.com 📰DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution. By Francisco Gimeno-Valiente, Nnennaya Kanu and colleagues. ⬇️ www.nature.com/articles/s41...

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

An innovative and fascinating sequencing tech detects DNA changes before they lock in as mutations... offering fresh insight into cancer, aging, & genetic disease. Explore the science behind it: www.biorxiv.org/content/10.1...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

New paper out today in @science.org! Very proud that my team was able to contribute to this fantastic work from @bethpsaila.bsky.social's group. In short: platelets contain a fair amount of cfDNA taken up from the surrounding! Read the summary by lead author @l-cmurphy.bsky.social:

Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679... You'll learn a lot and it'll be fun and interesting! #DKTK @dkfz.bsky.social @lmumuenchen.bsky.social

New paper from our lab - ‪@bbglab.bsky.social‬. Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection academic.oup.com/nar/article/... Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

new out in Nature yesterday www.nature.com/articles/s41...

Dive into the step-by-step choreography of transcription-coupled DNA repair. In our new review published in Nature Cell Biology, we explore what we know and what’s next in this exciting field of research! www.nature.com/articles/s41...

🚨 Looking for postdocs! I'm starting my lab at UT Southwestern this September. If you're interested in: 🧬 Somatic & germline mutagenesis 🐭 Evolution of mutation processes 🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining. Formal ad coming soon. DM me!

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. 👉 Early cancer detection 👉 Methylation drivers 👉 Epimutation rates 👉 CpG lineage tracing www.biorxiv.org/content/10.1...

Last but not least, if you're interested in somatic mutations, new technologies and computational genomics - we're hiring a postdoc in my brand new lab @emblebi.bsky.social! Reach out if interested or you have any questions, and apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

new out in Nature this week www.nature.com/articles/s41...

We’re hiring! Postdoc in Computational Genomics at @uoe-igc.bsky.social Focus: myeloma, structural variants, heterochromatin, multiomics Deadline: 9 July 2025, 23:59 GMT Apply: elxw.fa.em3.oraclecloud.com/hcmUI/Candid... #myeloma #postdoc #genomics #bioinformatics #epigenetics #codeandkilts

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

. @pnas.org just published the final version of our manuscript on how generation time and effective population size interact to shape vertebrate germline mutation rates, led by Luke Zhu and Annabel Beichman: www.pnas.org/doi/10.1073/...

If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...

Social media grump Kamila has finally made it onto Bluesky! Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news. I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.

We are hiring! Want to join my new group at the amazing @uoe-igc.bsky.social and perform ground-breaking studies in reproductive genomics and genomic medicine as a computational genomicist? Please DM me to discuss this, I will be attending #ESHG2025 elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy Published @natcancer.nature.com Melissa is an outstanding new clinician scientist.. one to watch. www.nature.com/articles/s43... @icr.ac.uk

🚨New preprint!🚨 Venturing out of the nuclear genome to explore #mtDNA: "Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis" www.biorxiv.org/content/10.1... Led by Dr. Maëlle Daunesse and @paulflicek.bsky.social - and many other #LCEConsortium members ⬇️

With the brilliant @mlockley.bsky.social we've been exploring chemo resistance evolution in ovarian cancer. We find resistance has a fitness cost which means resistant cells are outcompeted by sensitive cells when treatment is stopped. aacrjournals.org/cancerres/ar... @icr.ac.uk @qmbci.bsky.social

Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1... #Genomics #SomaticEvolution

I had an incredible time at the Mutations in Time and Space conference last week! There were a ton of interesting talks and I so appreciate the engagement with my work. Excited for more! #MITS25

Proud to have Prof Nicky McGranahan #CRUKFunded who co-lead City of London Centre Cancer Evolution theme charing and speaking about immunology and somatic evolution at #AACR25!

If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...

New online! Advances in single-cell DNA sequencing enable insights into human somatic mosaicism

Thank you to the Mutations in Time and Space #MITS25 organisers (and fellow attendees!) for a fantastic few days of Dynamic, Exciting, and Interesting science and people @broadinstitute.org A great week with old friends and collaborators, and making new ones... See you again in 2026 💙

Mutations in Time and Space 2025 #MITS25 was a fabulous meeting! So much science to digest over the weekend. Special thanks to the Broad for hosting. A special art connection between the MIT campus and the Allen Institute (my next door neighbor) in Seattle. Shared Jaume Plensa sculptures.

Bye Boston. It was a great conference. #MutationsInTimeAndSpace

This meeting wouldn't have been possible without our amazing sponsors and all the great attendees. Thanks everyone!! #MITS25

The best speaker prizes go to Jennifer Ziegenfuss and Sarah Carioscia!! #MITS25

Well done to the poster prize winners #MITS25 Daan Andel Bradley Class Duncan Odom Sean Laidlaw

That's a wrap! Thanks for all your work Tim, Kristin and Brady for leading the organisation #MITS25

Last talk! Bob Handshaker from Steve McCarroll's lab is taking us through mosaicism in Huntington's disease. #MITS25

Jennifer Ziegenfuss from UMass is up next, telling us about neurodegeneration in Parkinson's #MITS25

Henry Lee-Six is up next at #MITS25

I'm biased, but I loved it, great talk!! Don't forget @s-j-aitken.bsky.social is hiring! She's a great scientist and person- you couldn't find a better PI.

Nicole Rockweiler is chairing the last part of #MITS25 kicking off with @s-j-aitken.bsky.social Sarah Aitken's phenomenal work 👏

Jimmy Bennett from University of Washington is being very supportive of #MITS25 before taking us through pediatric cancers...

Maria Torra I Benach is teaching us about Teratomas- awesome! #MITS25

Martin Bloomer shows us the Naxerova lab's cool methods for finding subclonal selection in colorectal cancer. Very cool #MITS25

It's a full house for Melissa Davis, who kicks off the last day of #MITS25 in the somatic mutations and disease session chaired by Martin Taylor.

New @science.org Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective www.science.org/doi/10.1126/...