@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Come to Germany and do a PhD with DKFZ. You'll be supported by an international community doing amazing science in a fantastic place. I joined the DKTK from the UK 3 months ago and couldn't be happier with how easy it has been fitting in. The quality of work here is phenomenal and you should apply!

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

The exciting next instalment of Mutations in Time and Space... Open for registration now

WEEKEND LISTEN This year, the Trump admin threw everything it had at the nation's oldest and richest university 3 Harvard profs tell the story of what they saw @naxerova.bsky.social @ryanenos.bsky.social & Kit Parker www.wnycstudios.org/podcasts/otm...

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. www.biorxiv.org/content/10.1...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

Welcome @timcoorens.bsky.social ‪ ‬🇳🇱, our new Research Group Leader. Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease. www.ebi.ac.uk/about/news/p... 🖥️🧬

Thank you for thinking of us. It’s been a rough ride. My lab lost two R01s, and as painful as that is for us, we are just one drop in a big bucket of terminations. HMS is doing everything they can to help us in the short term, but we need long term solutions - please keep up the conversation.

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

Very cool!

Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx. 👉 Early cancer detection 👉 Methylation drivers 👉 Epimutation rates 👉 CpG lineage tracing www.biorxiv.org/content/10.1...

We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!

To what extent is cancer development deterministic and predictable..? Does the germline genome affect that predictability...? Preprint: www.biorxiv.org/content/10.1...

🚨 Looking for postdocs! I'm starting my lab at UT Southwestern this September. If you're interested in: 🧬 Somatic & germline mutagenesis 🐭 Evolution of mutation processes 🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining. Formal ad coming soon. DM me!

Social media grump Kamila has finally made it onto Bluesky! Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news. I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.