Huge congratulations to the lead applicants to our Development Fund 2025 on their innovative ideas! 👏 Özgen Deniz; Jonathan Fisher; Paul Grevitt; Jit Sarkar; Adam C Sedgwick; Emmanouil Stylianakis; and @zaccasimo.bsky.social 🎉 Find out more about their projects here: www.colcc.ac.uk/development-...

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

🚨 We're hiring a sequencing technician in #TRACERx! Join world-leading teams at @TheCrick & @uclcancer, working at the forefront of cancer research. Want to apply cutting-edge genomic tech to understand cancer evolution? Apply now! 👉 www.ucl.ac.uk/work-at-ucl/... #Genomics #CancerResearch

1 in 2 people will get cancer in their lifetime. Our team'll still run @cancerresearchuk.org Muddy Race also this May to highlight the importance of funding cancer research and improving patient outcomes Please support us if you can! #RaceforLife 👉 fundraise.cancerresearchuk.org/team/computa...

Not only are you a brilliant PI and an incredible mother, but you’re also a role model for women in science. Your strength and dedication inspire us all!

I'm attending #ISMBECCB2025 in Liverpool, United Kingdom from July 20-24. Who else is going? Register here and don't miss it! invt.io/1bxbyktm0wq

Huge congratulations to now PhD @alexsteinresearch.bsky.social and supervisor @benjaminwerner.bsky.social , well deserved! It has been a pleasure to listening to and discussing such a great amount of work and how it all came together

To what extent is cancer development deterministic and predictable..? Does the germline genome affect that predictability...? Preprint: www.biorxiv.org/content/10.1...

A big moment for our Centre - the first algorithm to identify cells responsible for aggressive tumour growth. SPRINTER can measure proliferation of distinct clones within the same tumour, using DNA sequencing data. This could facilitate better prediction of cancer progression, informing treatment.

How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this Cancer Research commentary, @zaccasimo.bsky.social and I discuss a recent Nature Biotech benchmarking paper exploring this question: bit.ly/3VAMRQs

🚨 Very proud of this commentary led by @rijazaidi.bsky.social reasoning on the impact of methods and experimental design on cancer evolution understanding, motivated by the outstanding work of @TheBoutros, @VanLooLab, @kellrott et al Original work 👉 doi.org/10.1038/s415... Our Commentary 👇

Reposting this list of #cancer #evolution scientists, in case its useful for the many newcomers.

So proud that our paper introducing SPRINTER to characterise clone proliferation through cancer evolution is out in Nature Genetics!

🎉 Hugely honoured & happy to be selected for the @embopress.org EMBO Young Investigator Programme 2024! Exciting opportunity for our group @ccg-ucl.bsky.social & grateful for the support of @uclofficial.bsky.social @uclnews.bsky.social & funders @cancerresearchuk.org www.embo.org/press-releas...

We are so grateful to @qianxidu.bsky.social for this outstanding News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here: 👉 doi.org/10.1038/s415... 🧵 Dive into SPRINTER's work: 👉 bsky.app/profile/zacc...

Our paper on chromosomal abnormalities in normal breast tissue from BRCA carriers came out last week. www.nature.com/articles/s41...

What an absolute pleasure to be collaborating with such an incredibly talented team!! SPRINTER out today in Nature Genetics 🧬

A great pleasure to work with @zaccasimo.bsky.social and his team on this elegant data and tool.

Single cell genomics was a breakthrough in understanding cancer heterogeneity. Incredible work by Lucas et al. in breaking the next barrier, cancer proliferation heterogeneity tinyurl.com/mjuuk7kt Honoured I was invited to write the News&Views. tinyurl.com/yc27a4ac Both out now in Nature Genetics!

🚨So proud to present the first study from our @ccg-ucl.bsky.social group together with @charlesswanton.bsky.social @NnennayaKanu and led by @ojlucas.bsky.social with key collaboration @sophie-ward.bsky.social and fundamental support @rijazaidi.bsky.social @abibunkum.bsky.social & others Out now👇 🧵👇