Marc Williams
@marcjwilliams.bsky.social
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Marc Williams
Trevor Graham
7 months ago
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In
@nature.com
today led by brilliant
@calumgabbutt.bsky.social
www.nature.com/articles/s41...
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Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
https://www.nature.com/articles/s41586-025-09374-4
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Our paper on chromosomal abnormalities in normal breast tissue from BRCA carriers came out last week.
www.nature.com/articles/s41...
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Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations - Nature Genetics
Single-cell DNA sequencing identifies recurrent copy number changes in healthy breast tissue from women with wild-type or germline BRCA1 or BRCA2 mutations.
https://www.nature.com/articles/s41588-024-01988-0
over 1 year ago
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