Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of mouse and human brain function @adamqbauer.bsky.social @jordacular.bsky.social @realjoshsiegel.bsky.social @oliverk28.bsky.social www.nature.com/articles/s41...

A study in Nature Neuroscience finds psychedelics disrupt the relationship between neuronal activity and blood flow in humans and mice. This suggests fMRI results under psychedelics may reflect vascular effects as much as neural ones and should be interpreted with caution. go.nature.com/47hqVPH 🧪

And the story continues to grow!!!

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬 We found that psilocybin prolongs the neurovascular response, independent of neural activity. This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging