Preprint out arguing that we should build the techology to translate (compile) molecularly annotated connectomes into dynamics. I think this is incredibly important. arxiv.org/abs/2603.25713

This work started when Christian Pehle, @tonyzador.bsky.social, and I found that training sequentially (consuming/producing one spike at a time) in JAX was prohibitively slow. You certainly can consume multiple spikes in parallel—TLDR; just use an associative scan—but... 2/N

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

Our paper “Multifidelity Simulation-based Inference for Computationally Expensive Simulators” has been accepted at ICLR 2026! 🥳 We hope this can be a practical solution for anyone analysing and doing inference on computationally expensive simulators. Paper: openreview.net/pdf?id=bj0dc...

We have a new preprint examining single neuron responses in humans undergoing TMS (www.biorxiv.org/content/10.6...). The excellent Charlie Dickey led the way, and I had the privilege to co-supervise this work with @coreykeller.bsky.social and @aaronboes.bsky.social 🧵 (1/7) 🧠🟦 🧠💻

A Spatially Structured Spiking Network Model of Beta Traveling Waves and Their Attenuation in Motor Cortex https://www.biorxiv.org/content/10.64898/2026.03.18.712701v1

Pleased to share that our paper "Representation Biases: Variance is Not Always a Good Proxy for Importance" is now out as Theory/New Concepts paper in eNeuro! www.eneuro.org/content/13/3... 1/

Happy to share a new preprint from my PhD thesis! “A novel framework for expanding RNNs with biophysical detail to solve cognitive tasks” 🧠💻 📝 www.biorxiv.org/content/10.6... @jonescompneurolab.bsky.social

Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function https://www.biorxiv.org/content/10.64898/2026.03.13.711751v1

We've been saying for a while now that beta bursts might be functionally heterogeneous. Check out @quentinmoreau.bsky.social's paper where we show that different types of bursts have different relationships to behavior in a sensorimotor adaptation task 👇👇👇

Mission: record hippocampal place cells in zero gravity Crew: 3 rats with electrode arrays Vehicle: Space Shuttle Columbia Status: data now publicly available on DANDI, 28 years later The ratstronauts' mission is finally complete. 🐀🚀 h/t NASA about.dandiarchive.org/blog/2026/02...

underappreciated concept 🙂 for more dipoles: neighboring dipoles have different orientations & can have different stimulus preferences. so even though topographies look similar, subtle differences remain. maybe that's why it is possible to decode information from relatively few sensors?

The angle of the dipole obviously matters. If active dipoles in two conditions are slightly misaligned, a difference can be observed. However, this difference is not driven by differences in amplitudes, but only by differences in orientations. Here, I simulated such a scenario. #brainmovies

Excited to share our new findings: distinct neural dynamics in prefrontal and premotor cortex during flexible decision making, preprinted on biorxiv. www.biorxiv.org/content/10.6...

Do you have an open working memory dataset and want it to be findable and reused? You can now add it to the Open WM Data Hub: williamngiam.github.io/OpenWMData! The collection of datasets tagged with useful metadata is steadily growing thanks to a small team of volunteers!

Unit tests in research code feel like something that's slowing you down until they wind up saving you six months of suffering

PhD position in computational neuroscience/brain physics to work with us on biophysical modeling of electric and magnetic brain signals at University of Oslo as part of the Marie Curie EU project @neuronanotechdn.bsky.social. Application deadline: December 9th. www.jobbnorge.no/en/available...

📍Excited to share that our paper was selected as a Spotlight at #NeurIPS2025! arxiv.org/pdf/2410.03972 It started from a question I kept running into: When do RNNs trained on the same task converge/diverge in their solutions? 🧵⬇️

The Jones comp neuro lab is at #SfN25! Come check out our talks and posters to learn about our latest & greatest Science with HNN! All poster presentation times & locations can be found at jonescompneurolab.github.io/textbook/res...

Excited to release our new work: Petri Dish Neural Cellular Automata! pub.sakana.ai/pdnca We investigate how multi-agent NCAs can develop into artificial life 🦠 exhibiting complex, emergent behaviors like cyclic dynamics, territorial defense, and spontaneous cooperation.

No tricks, just brains in 3D 🧠🧟‍♂️ This cleared human brain slice (~10×7×0.3 cm) was imaged at 0.17 µm/pixel on the 3Di HOTLS lightsheet microscope. Sharp, transparent, undead-level perfection (Alpenglow Biosciences). #3Dtissueimaging #LightSheet #Halloween

Today at #PracticalMEEG2025 Nick @willenjoy.bsky.social and I will be conducting a tutorial on how to simulate EEG/MEG data with our toolbox meegsim. If you happen to be around, come to our virtual booth; we will tell scary stories.👻

Revised version of our #NeurIPS2025 paper with full code base in Julia & Python now online, see arxiv.org/abs/2505.13192

Check out our latest work led by @joeyzhou.bsky.social on alpha oscillatory networks in PLOS Biology! ➡️ journals.plos.org/plosbiology/... Do ongoing alpha activity fluctuations influence perceptual sensitivity or criterion?

🚨Postdoc job offer🚨 Are you interested in beta bursts? Want to help drive methods for laminar inference with MEG? Now hiring a postdoc: run head-cast MEG experiments, help build our laMEG toolbox, and collaborate across Lyon–Marseille–Strasbourg. emploi.cnrs.fr/Offres/CDD/U... Please repost! 🧠📈

Is the the neuroimaging community (broadly conceived) submitting to 𝗡𝗲𝘂𝗿𝗼𝗶𝗺𝗮𝗴𝗲 again????? Not to be publication police but the shift had seemed major 1-2 years ago. Looking at the editorial board it seems to have serious scientists once more. Curious about thoughts of the community.

𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻?? Astrocytes in the regulation of fear memories! www.nature.com/articles/s41... #neuroskyence h/t @claeneuro.bsky.social

Can AI simulations of human research participants advance cognitive science? In @cp-trendscognsci.bsky.social, @lmesseri.bsky.social & I analyze this vision. We show how “AI Surrogates” entrench practices that limit the generalizability of cognitive science while aspiring to do the opposite. 1/

Thrilled to share our new preprint highlighting distinct neurocomputational mechanisms underlying how reward and punishment determine adaptive cognitive control - a massive fMRI study and collaborative team effort with the @shenhavlab.bsky.social 🧠 Link here: www.biorxiv.org/content/10.1...

Map of spiking activity underlying change detection in the mouse visual system https://www.biorxiv.org/content/10.1101/2025.10.17.683190v1

Definitely looking forward to helping run this workshop!

📜🎉 I'm happy to share that my review of clinical research investigating aperiodic neural activity is now published! It examines 177 reports of aperiodic activity in clinical disorders summarizing findings, discussion topics, & making some recommendations! onlinelibrary.wiley.com/doi/10.1111/...

A glimpse at what #NeuroAI brain models might enable: a topographic vision model predicts stimulation patterns that steer complex object recognition behavior in primates. This could be a key 'software' component for visual prosthetic hardware 🧠🤖🧪

Rapidly Reconfigurable Dynamic Computing in Neural Networks with Fixed Synaptic Connectivity https://www.biorxiv.org/content/10.1101/2025.10.05.680523v1

Multi-stable oscillations in cortical networks with two classes of inhibition https://www.biorxiv.org/content/10.1101/2025.10.03.680414v1

Neuropixels Ultra! By @steinmetzneuro.bsky.social, who led a big collaboration www.sciencedirect.com/science/arti...

Really great article! I spent a lot of my PhD helping turn the HNN model into an open source python package We can boast that it’s super quick to install, definitely worth playing around with the GUI or python code if you’re interested in simulating EEG signals with biophysical neurons 🧠 🌊

If you’re a @cogneuronews.bsky.social member, check out and vote on the great lineup of symposia for 2026, and plz consider our symposium “Non-invasive meso-scale dynamics of perception and cognition”, organized by @adykstra.bsky.social including James Bonauito and @lonikefaes.bsky.social!

Thanks for organizing this awesome workshop @rdgao.bsky.social!

Our PhD student @ntolley.bsky.social successfully defended his thesis, "Bridging biophysics and emergent dynamics through deep learning assisted modeling of the neocortex", on July 9th, 2025. Congratulations Dr. Tolley!!! 🎉🎉

Postdoc job alert! I’m looking for someone with a PhD in neuroscience/psychology, psychiatry, biomed engineering, computational modeling or a related field to join my NIH-funded team at UCLA studying the neural & computational mechanisms of #interoception in anorexia nervosa 1/2

New preprint: SBI with foundation models! Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️

I’m quite excited to share that I successfully defended my PhD in Neuroscience at Brown University! I’ve been extremely fortunate to be advised by Stephanie Jones and Carlos Vargas-Irwin, who have been fantastic mentors at every stage. And of course a huge thank you to all my colleagues and friends.

Want a high-level overview of how HNN works? Check out this short comic by our lab manager Joyce (@kermieeart.bsky.social)! tinyurl.com/27xrksez #compneuro #sciart #comics

The geometry of the neural state space of decisions - looks like very cool new work, highlights utility of integrating response time distributions into neural modeling

I know it doesn't matter, but I am so confused by this idea floating around that a dynamical systems approach is somehow without representations. It is not how I nor many other computational neuroscientists I know would think of these things. www.cambridge.org/core/books/r...

Is our brain infinitely flexible or constrained? Oby & colleagues cleverly uses BCIs to test what cortical activity can/can't be generated quickly. Highly recommend! www.nature.com/articles/s41... And you can get a tl;dr + my takes on why this is exciting here: www.nature.com/articles/s41...

New 💥beta burst💥 paper! With Sotirios Papadopoulos, Jérémie Mattout of @cophy.bsky.social, and @maciekszul.bsky.social, we show how waveform-specific beta burst rates outperform classic motor imagery BCI approaches based on beta power direct.mit.edu/imag/article...

Congrats to Sam Mestern, Ph.D. student at @westernu.bsky.social, for winning the MapMySpikes challenge! His tool, PatchOTDA, excelled in mapping electrophysiological data to molecular properties. 🧠📈 More on his tool and the MapMySpikes challenge: alleninstitute.org/news/canadia...