Two new articles from our lab!! Davis et al identified epithelial transcription factor ELF3 as a key mediator of host-microbiota interaction in zebrafish tinyurl.com/pkavnxdp Morash et al revealed enteroendocrine cell subtypes in zebrafish & catalogued their peptide hormones tinyurl.com/bdzbm2xm

Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy link.springer.com/article/10.1... 🔓

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

Nov 18 is the deadline for short talk abstracts + scholarship apps for the Keystone Symposium on Islet Biology & Diabetes. Hear more from @linnemannlab.bsky.social: 🎥 youtu.be/4olDczSNJMo. Apply: keysym.us/KSDiabetes26 #KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social

The deadline for short talks at the Keystone Islet Biology symposium is approaching (Nov 18th) - submit it here: www.keystonesymposia.org/conferences/... For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives) novonordiskfonden.dk/en/grant/pos...

Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

🚨 Just out in Nature Communications: Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish We challenge old assumptions on liver regeneration! 🔗 nature.com/articles/s41... 🧵(1/8)

Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen www.nature.com/nchembio/vol... @ckarampelias.bsky.social @uu.se

Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment. Apply here: uu.varbi.com/en/what:job/...

We’re excited to share our recently published story “A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing” in @mucosalimmunol.bsky.social Fantastic work led by @ramoralescastro.bsky.social ! www.mucosalimmunology.org/article/S193...

What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues. www.science.org/doi/10.1126/... #academiasky

At the Stainier lab’s 30th year celebration, funtastic colleagues

Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted: uu.varbi.com/en/what:job/...

Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes... www.cell.com/cell/fulltex...

Deadline extended to March 23!!👇

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates www.science.org/doi/full/10....

Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!

Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...

Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities) www.uu.se/en/about-uu/...

Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)

Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social www.biorxiv.org/content/10.1...

Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-release...

2024 saw another record for bioRxiv postings. Thanks to all the CSHL staff, affiliates, authors, funders, and everyone who advocates for the project. Happy New Year and #letsmakethisthenorm ! 🧪

Up front & free to read in our Jan issue #editorspicks: Molecular mechanisms underlying glucose‑dependent insulinotropic polypeptide secretion in human duodenal organoids tinyurl.com/muc8sata