A double-blind replication attempt of offline 5Hz-rTUS-induced corticospinal excitability pubmed.ncbi.nlm.nih.gov/41395365/ (tl;dr: it didn't work)

Noninvasive deep brain stimulation using theta-burst transcranial magnetic-acoustic coupling to modulate cortical rhythms in Parkinsonian mice pubmed.ncbi.nlm.nih.gov/41386342/

Even Nobel prizewinners can experience impostor syndrome. John looks as shocked here as he did on 7th October.

It seems a bunch of groups are leaping into tFUS for neuromodulation without assessing effects of tFUS on CBF with ASL, or on vascular territory effects using cerebrovascular reactivity. Seems like a giant oversight to me!!!! (My five bucks says tFUS is primarily vascular...)

Further proof, if it were needed, that Suffolk peaked 400 millenia ago and has been going downhill since. (Local radio peaked shortly thereafter, along with fashion.) www.nature.com/articles/s41...

Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation https://www.biorxiv.org/content/10.64898/2025.12.03.692212v1

Non-invasive modulation of brain activity and behavior by transcranial radio frequency stimulation https://www.biorxiv.org/content/10.1101/2025.11.27.691064v1

Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature www.nature.com/articles/s42...

Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability pubmed.ncbi.nlm.nih.gov/40899987/

Deep cerebellar tFUS engages cortical circuits via convergent local and sensory-driven mechanisms https://www.biorxiv.org/content/10.1101/2025.11.15.688639v1

For anyone now freaking out, remember there are three legs to the AI/ML/DL stool: 1. the hardware & power to do the computations, 2. the algo/model being deployed, and 3. the data. Collecting good data may never have been so important.

AI is Suddenly Surprisingly Good at Physics youtu.be/njNrTUMC6qE?...

Not quite ready for routine use, but a big step towards what would be a wonderful scan to include in all fMRI protocols. It gets a variable delay ASL, angio and variable contrast T1 anatomical all from the same set of data! pubmed.ncbi.nlm.nih.gov/40955094/

Calling electrical engineers, what do you think of the suggestion that there's a capacitive E field between the transducer and the brain which contributes at least some of the neuromodulatory effects of tFUS? Presumably this DC effect would manifest at the pulse repetition rate.

Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation https://www.biorxiv.org/content/10.1101/2025.11.02.685597v1

Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging pubmed.ncbi.nlm.nih.gov/41171932/

Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects #neuroskyence #PsychSciSky www.nature.com/articles/s41...

High frequency oscillations measured with optically pumped magnetometers from the human retina https://www.biorxiv.org/content/10.1101/2025.10.27.683907v1

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating https://www.biorxiv.org/content/10.1101/2025.10.24.684433v1

If metabolic water production rate can explain a good 90%+ of MSM washout from brain tissue then there isn't a whole lot of need for CSF influx (via glymphatic, perivascular or any other routes) to account for tissue clearance. Perhaps we've been barking up the wrong tree? (2/2)

Interesting observation du jour... In 2020 we reported MSM (aka DMSO2) washout from brain, getting a half-life of 72 hrs (10.1002/mrm.27997, Fig 5C). Metabolic water production of 0.11 µL/g/min (~15% wt/wt turnover per day) as estimated here accounts for almost all the MSM clearance we saw. (1/2)

A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep pubmed.ncbi.nlm.nih.gov/40329309/

Indirect Deuterium Displacement Exchange Imaging for Non-invasive High-Resolution CSF Production Mapping https://www.biorxiv.org/content/10.1101/2025.10.20.683579v1

Region-specific drivers of CSF mobility measured with MRI in humans pubmed.ncbi.nlm.nih.gov/41087750/

🎤 Calling Multi-Echo fMRI Researchers 🎤 Preparing for OHBM? Get expert feedback before the deadline! 🌟 Tedana devs will possibly host a multi-echo meeting on Dec 8th to make sure your abstract is perfect for submission. Interested? DM me or other tedana devs! #neuroskyence #neuroimaging

Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns pubmed.ncbi.nlm.nih.gov/41064374/

Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases https://www.biorxiv.org/content/10.1101/2025.10.07.680973v1

WATCH: 3 scientists who helped advance quantum technology win Nobel Prize in physics www.pbs.org/newshour/sci...

Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI pubmed.ncbi.nlm.nih.gov/41008269/

New paper in Imaging Neuroscience by Roza G. Bayrak, Catie Chang, et al: DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics doi.org/10.1162/IMAG...

Thinking about Angelo Mosso's brain balance method recently. There was a confound not mentioned in a 2014 review (pubmed.ncbi.nlm.nih.gov/23687118/). Blood is 1.06 X water density, but CSF will be forced out of the ventricles as CBV increases (Monro-Kellie doctrine) so net weight sensitivity is low.

Brain thermal response to low intensity focused ultrasound at the action potential level and neuron response to various stimulus pubmed.ncbi.nlm.nih.gov/40967140/

Really interesting info relevant to magnet safety: mriquestions.com/most-dangero...

Interesting approach to tissue-CSF water exchange, but someone please tell me how MT on/off difference images aren't affected by cardiac pulsatility in the perivascular spaces & lateral ventricles. How could we prove/disprove local motion effects? pubmed.ncbi.nlm.nih.gov/40950437/

Ultrasound system for precise neuromodulation of human deep brain circuits pubmed.ncbi.nlm.nih.gov/40913042/

We are looking for our next colleague. Feel free to reach out to me if you have questions!

Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults https://www.biorxiv.org/content/10.1101/2025.08.29.673075v1

Functional imaging of hippocampal layers using VASO and BOLD on the Next Generation (NexGen) 7T Scanner https://www.biorxiv.org/content/10.1101/2025.08.29.673151v1

Update on the reproduction and interpretation of DIANA fMRI https://www.biorxiv.org/content/10.1101/2025.08.31.673005v1

Functional MRI signatures of autonomic physiology in aging. pubmed.ncbi.nlm.nih.gov/40858848/

Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners https://www.biorxiv.org/content/10.1101/2025.08.25.672075v1

All the more reason to use VASO.

Vascular draining confounds laminar decoding in fMRI https://www.biorxiv.org/content/10.1101/2025.08.26.672278v1

For the laminauts. @layerfmri.bsky.social

Anyone ever come across a study which used a simple visible light bore camera (instead of an IR light source & camera) to assess pupil diameter during fMRI, e.g. for arousal or vigilance monitoring?

Please repost. The Centre for Functional and Metabolic Mapping is looking for a Preclinical MRI physicist (9.4T and 15.2T Bruker Advance Neo). You will join a team of 14 dedicated staff in Canada's National Ultra-high field MRI platform who also operate 3T and 7T human scanners in the same facility.

New paper in Imaging Neuroscience by Dinil Sasi Sankaralayam, Hanzhang Lu, et al: The dependence of CO2 cerebrovascular reactivity (CVR) on caffeine doi.org/10.1162/IMAG...

Read the whole thread. Beautiful work.

Nice work by @yoichimiyawaki.bsky.social showing the fMRI hemodynamic response contains enough info to decode stimulus type within 2sec. Happy to have helped with this project. www.biorxiv.org/content/10.1...