🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP

When a brain researcher solved a logistical problem by going rogue, the idea proved remarkably infectious. By @lyrebard.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

I’m very happy to share the latest from my lab published in @Nature Hippocampal neurons that initially encode reward shift their tuning over the course of days to precede or predict reward. Full text here: rdcu.be/eY5nh

📣 Our lab is hiring a full-time RA/lab manager! Join us in beautiful Santa Barbara to study the neural bases of affect-cognition interactions using fMRI and brain stimulation. Great stepping stone to a PhD in cognitive/affective neuro 🧠🐬🏖️ Apply by Jan 22: recruit.ap.ucsb.edu/JPF03048

Researchers using microprisms: I am planning to place a custom order from FST for 1.5 mm wide diamond knives with a 30 deg point (similiar to finescience.com/en-US/diamon... but with a 1.5mm wide blade), but there is a minimum lot number. Anyone else interested in purchasing one? Let me know!

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

Want to track the dynamics of estrogen in the brain across long periods of time? New paper as part of very fun collab with team UCLA Ed Van Veen and Steph Correa! We use a specialized optical reporter and show that this is possible and actually very easy! www.biorxiv.org/content/10.6...

Our lab is hoping to hire a long-term lab manager / research associate to help with admin tasks and neuroscience experiments (3-year minimum commitment). bilh.wd1.myworkdayjobs.com/External/job...

Excited to share my first PhD preprint! “How human aging disrupts the head direction network: evidence from VR experiments and mechanistic models” We investigated why our sense of direction becomes less stable as we age. Preprint: www.biorxiv.org/content/10.1... 1/ thread 🧵

Hearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers. I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research. As @jenna-m-norton.bsky.social put well: 1/

Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41... #blueprint 1/7

Six of the nine Nobel Prize winners this year work in the U.S. Three of the six were born outside the U.S., which is the pattern most years. No country has benefited more from welcoming immigrants from around the world. www.nobelprize.org

Exciting news: #UCSB physicists John Martinis and Michel Devoret have been awarded the 2025 #NobelPrize in Physics. They were lauded for work that, according to the Royal Swedish Academy of Sciences, "revealed quantum physics in action." Full story: https://ow.ly/TH7K50X7ULp#UCSB

With the power of the people behind it, the California legislature just passed the Menopause Care Equity Act. This is history in the making—finally addressing a health gap that touches millions of women. Now, it’s down to one signature. @governor.ca.gov, the pen is in your hand. 🖊️

🧠✨ Women in Neuroscience History: The Pioneers Who Changed Everything Incredible stories of 11 women who revolutionized brain science, often against impossible odds. Meet trailblazers of sleep research, memory science, neuroplasticity, and neurosurgery — from Maria Manasseina to May-Britt Moser 🧠

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

Following up: searching for the distribution of estrogen receptors in the brain, I realized the Allen Brain Atlas is male only. How is it possible that something this fundamental is still missing?

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

Our latest profile just dropped! Dr. Emily Jacobs (‪@emilyjacobs.bsky.social‬) studies how hormonal fluctuations influence the brain. Follow the link below to listen to the full interview! www.storiesofwin.org/profiles/202... #WomenInNeuroscience #StoriesOfWiN

Excited to announce that my lab has moved to UC Berkeley Dept of Neuroscience and Dept of Statistics! I will be continuing to collaborate with colleagues and students in TX at UT Austin and Baylor College of Medicine, and will start new collabs in the Bay. Will be taking new grad students this fall!

I’m excited to share my final co-first author paper from my postdoc in Dan Dombeck's lab! We explored how behavior, senses, and neurons influence how much information in the brain changes over time. www.nature.com/articles/s41... #science #research #neuroscience #hippocampus #placecells

Took a break from worrying about funding to do some climbing in Squamish! (Elowen’s first multi-pitch)

A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently. Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries. www.biorxiv.org/content/10.1...

Can your AI beat a mouse? Mice still outperform our best computing machines in some ways. One way is robust visual processing. 10 years ago I decided to work on HARD behavior driven by COMPLEX visual processing. And that risk is paying off now. #neuroAI 1/n

The FY26 budget will devastate our innovation driven economy. A summary in 3 parts... Part 1 - The White House vision for dismantling science, as described in one simple plot, means slashing budgets of NIH, NASA, NSF & going back 25 years (or more). joshuasweitz.substack.com/p/the-white-...

Very happy to see a Transmitter (@thetransmitter.bsky.social) piece on our recent work on estrous cycle modulation of hippocampal structure and function. Thanks to Sydney Wyatt (@sydneywyatt.bsky.social) for covering the work and its context: www.thetransmitter.org/neuroendocri...

Riddle: When is an "optical invariant" is not so invariant? How can you get a larger field-of-view for free? No change in resolution or scan speed. No more stitching needed! For #MicroscopyMonday here's a new preprint to check out. 1/9

Now out in @natcomms.nature.com‬: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7) www.nature.com/articles/s41...

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd. It's not just budgets but research, institutions, expertise, and training the next generation.

We’re international students at Harvard. We’re afraid to write this. But we have to speak up. www.washingtonpost.com/opinions/202...

Huge congrats, Will! Can't wait to see the work from your lab!

Online now:

🚨Very excited to share a new paper from our lab in Neuron (@cp-neuron.bsky.social) on the influence of the estrous cycle on structural and functional plasticity in the hippocampus: www.sciencedirect.com/science/arti... Thread below 🧠🧪🧵:

Join us in beautiful Santa Barbara! We're hiring a full-time junior specialist/research technician to play a central role in data collection & analysis of brain imaging studies of pregnancy & menopause. Learn more & apply at: recruit.ap.ucsb.edu/JPF02974 Or help us spread the word 💫

🚨New paper from the Epp and Sargin Labs!🚨 We identified early sex- and region-specific impairments to parvalbumin interneurons (PV-INs) during Alzheimer’s Disease (AD) pathogenesis www.science.org/doi/10.1126/... Simplified highlights below: 🧵/15

🚨new paper alert Blind mice use stereo olfaction, comparing smells between nostrils, to maintain a stable sense of direction. Blocking this ability disrupts their internal compass. Kudos to @kasumbisa.bsky.social! Another cool chapter of the Trenholm-Peyrache collab😉 www.nature.com/articles/s41...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12

Check out our new paper, that reveals both the striking generality of cortical circuit organization, but also what we think are key differences in the scales of local excitatory and inhibitory networks across cortical areas. www.jneurosci.org/content/45/1...

Sex Differences Research Saves Lives! #OSSD #BoSD #SBN #SWHR #science please share rdcu.be/ecZXa

“[T]his is a moment to speak publicly about why universities matter. They promote public health, economic growth and national security. They are the largest employers in some regions. They are an unmatched, if imperfect, engine of upward mobility that can alter the trajectory of entire families.”

New "version of record" of our article on the effect of robust within-module grid cell variability on spatial coding in @elife.bsky.social. Check out @wtredman.bsky.social's explainer thread below:

1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social Video: www.youtube.com/watch?v=yw_4... Paper: www.nature.com/articles/s41...

Neuropixels and Optogenetics are delighted to announce the birth of Neuropixels Opto Combining high-resolution electrophysiology and optogenetics Today in bioRxiv 960 sites, 28 emitters, 2 colors By Lakunina, @karolinazsocha.bsky.social, Ladd, et al www.biorxiv.org/content/10.1... (1/2)

New preprint from the lab: Disrupted spatial and contextual memory encoding in the hippocampus of 5xFAD mice precedes cognitive impairment. Yimei Li, Mary Ann Go, Hualong Zhang, Simon Schultz. www.biorxiv.org/content/10.1...

Perfect periodicity in grid cells would make decoding locations degenerate in large spaces. Slight distortions in grid patterns, as observed in vivo, solve this problem, enabling precise spatial navigation. Final version of the manuscript is now available 👇 elifesciences.org/reviewed-pre...

Early morning panel on Spatial Perception, Memory, and Navigation today @ 7:30am in the Pyramid Peak room! #wcbr

The antidote for despair is action ❤️ * Dial (202) 224-3121 * Enter zip code * Leave voicemail * Say “My name is ___, I’m a constituent in [town]. (If clinician/scientist, say so) “The NIH freeze harms research and patients and must be lifted immediately.” Be brief. Staffers tally all calls. Go! ✅