Very cool new research from the Mellor lab continuing the BTSP story: CA1 OL-M neurons decrease their activity in novel environments, ungating EC inputs and enabling formation of new place fields. www.nature.com/articles/s41...

Another masterpiece from the Conant lab! Hapln2 is elevated in ApoE4 mice, yet another example of perineuronal net dysfunction in #Alzheimers www.biorxiv.org/content/10.1...

The Power Pixels pipeline just keeps getting better! The latest update comes with: - OpenEphys support - AP_Histology support - automatic high-frequency noise reduction - NWB format export option - zarr compression of raw data And, most importantly: a cool new logo! github.com/NeuroNetMem/...

#SfN25 attendees - make sure to head to the posters when you get to the meeting on Saturday afternoon (V7-V11: Gretchen, Megan, Margaret, Louisa, Bella) and Sunday morning (KK17: Micaela) to hear about our work. We're printing the posters now and they look rad.

Here's the full lineup of the Art of Neuroscience exhibitors at #SfN25 in San Diego #sciart 🧠

How does the brain find its way in realistic environments? 🧠 Using deep RL and neural data, we show that hippocampal-like networks support navigation, learning, and generalisation in partially observable environments—mirroring real animal behaviour. Now out: www.nature.com/articles/s41... #neuroAI

My co-authors have yet to move to Bluesky, so I'm pleased to announce our latest work has just been published in @nature.com Neuroscience. Amazing work led by Junheng Li, revealing that falling asleep follows a predictable bifurcation pattern #neuroskyence #sleep www.nature.com/articles/s41...

When the Black Lives Matter protests broke out around the nation, I was one of those who was challenged to look at my own life and what I could do to change the system. I wrote this piece, and every word remains as true today as it did in 2021 www.molbiolcell.org/doi/10.1091/... 🧪

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

Of all the amazing things that I've heard these past 2 days, I want to amplify this one in hopes that if there is a trainee out there that needs to hear this, it will reach them. Viviana is among the best minds of this era. Her story is telling. She said (and I endorse):

This recent survey by Nature reveals the happiest PhDs in the world👇 Brazil, Australia, and Italy report the highest PhD satisfaction, though for very different reasons.

Neuroscience projects last several years, and you are usually a bit jaded by the time you wrap it up. Not this one– spending several months on an island in the middle of nowhere, away from all the craziness of the world reminds you how beautiful the world really is. www.youtube.com/watch?v=46sv...

In this month’s “Liftoff,” @neurojacob.bsky.social talks about how there is no one “holy” method in neuroscience, and @izzynchristie.bsky.social reflects on her mentor’s advice and the value of persistence. By @franciscorr25.bsky.social #neuroskyence www.thetransmitter.org/liftoff-new-...

Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)

Want to make publication-ready figures come straight from Python without having to do any manual editing? Are you fed up with axes labels being unreadable during your presentations? Follow this short tutorial including code examples! 👇🧵

Foraging in conceptual spaces: hippocampal oscillatory dynamics underlying searching for concepts in memory www.biorxiv.org/content/10.1...

Distinct neocortical and entorhinal networks for time, space, and reward https://www.biorxiv.org/content/10.1101/2025.10.13.682150v1

New paper - Sex differences in healthy brain aging are unlikely to explain higher Alzheimer’s Disease prevalence in women: https://doi.org/10.1073/pnas.2510486122

Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine: www.nature.com/articles/s41... I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).

There is now strong, converging evidence that OFC neurons signal expected uncertainty. We manipulated probabilistic outcomes, and Zhang & Zhou changed reward delay and magnitude, finding OFC neurons dynamically modulate outcome-coding sensitivity based on variance www.science.org/doi/10.1126/...

🚀 New Preprint from our team: comparing place cells across species! Disentangling methods from biology provides a roadmap for cross-species insights into spatial coding 🌍 👉 www.biorxiv.org/content/10.1...

I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social ! With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

🚨 New paper in Nature Methods: HippoMaps: multiscale cartography of the human hippocampus Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG) Led by @jordandekraker.bsky.social docs: hippomaps.readthedocs.io paper: doi.org/10.1038/s415...

Information for the NIH Extramural Community During the Lapse of Federal Government Funding (as of October 1, 2025) grants.nih.gov/grants/guide...

1/8 How can the brain create countless unique memories using a single, universal metric of space? We’ve been waiting for the answer to this for two decades! Read it here: www.biorxiv.org/content/10.1...

1/ 🚨 New preprint! 🚨 Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇 📄 www.biorxiv.org/content/10.1... 💻 code + data 🔗 below 🤩 #neuroskyence

🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

@blackinneuro.bsky.social Good morning, and happy #BINW25 🎉 If you're joining on-line, check your inbox for your link to join the #BINW25 zoom. You can also follow along with livestream here: www.youtube.com/blackinneuro... If you're joining in person, can't wait to meet you! 🤩

Working with trainees is a highlight of my own research and a main goal of the New York Memory Hub. I'm looking forward to a great afternoon of discussion with a group of brilliant trainees. Space is limited, register soon!

Jewish High Holidays are coming up, so time for my annual PSA! Please consider avoiding scheduling major, unmissable events for: 🍎Tuesday, September 23 (Rosh HaShanah) 📯Thursday, October 2 (Yom Kippur) Many folks don't work those days, myself included.

Super excited to share the first cooperative foraging paradigm in freely interacting mouse pairs! Stable leader and follower roles emerge spontaneously and predict learning. Well-trained mice show stereotyped, role-specific “behavioral motifs” absent in naive animals (1/5) doi.org/10.1101/2025...

There's a very cool Buzsaki #neuroskyence paper out in Science this week, looking at hippocampal spatial information encoding by multiple interneuron subtypes in parallel. The brilliant @agonru.bsky.social and I wrote a wee perspective to go alongside it: www.science.org/doi/10.1126/...

Cool new findings on interneurons and spatial coding. Nice! www.science.org/doi/10.1126/...

A cell type is defined as the minimal unit to make a developmental biologist mad about a conversation

A great opportunity to work on stellar science with a magnificent mentor!

Feeling like a real PI this week: ✅submit my first >$1M grant ✅apply for a DEA license ✅buy my first roll of @parafilmm.bsky.social

This paper has everything: - a predator avoidance task with an eagle puppet 🦅 - rigid place coding and behavior in an #Alzheimer's model - another predator avoidance task, with a taxidermied weasel 👀 Run, don't walk, to read one of my favorite papers this year: www.cell.com/cell-reports...

The @flatironinstitute.org is hosting a 2-day workshop on Python packages for neural data analysis ( @pynapple.bsky.social NoMoS) prior to #SfN2025: neurorse.flatironinstitute.org/events/2025/.... Apps due Sept 8. And best of all, it's free, including meals and lodging! Go check it out!

this reminded me to post my 2-year reflections on starting a lab - perhaps useful? of course it's early days still so take all with a grain of salt 😬 www.gillespie-lab.com/year2reflect... (also tagging @marisosa.bsky.social and @emilyaeryjones.bsky.social )

👇Gold mine of advice for new PIs!

Thanks @avaskham.bsky.social & @thetransmitter.bsky.social for including me in this discussion of why individual differences matter. My work & others show that tracking individual behavior can reveal circuits & mechanisms that group averages miss #neuroskyence www.thetransmitter.org/animal-behav...

Great new review on neural manifolds by @juangallego.bsky.social and @mattperich.bsky.social. Amazing read. Lots of intuition and examples. Great synthesis of why manifold structure pops up everywhere in neuroscience, from motor control to cognitive tasks. www.nature.com/articles/s41... 🧠🧪 1/3

Hung-tu Chen, Nicolas Tritsch, Matt van der Meer, and I have submitted a new preprint (doi.org/10.1101/2025...) in which we use simultaneous hippocampal ephys and ventral striatal (VS) fiber photometry to establish a link between sharp-wave ripples (SWRs) and VS dopamine (DA) in mice. (1/9)

📢 Calling all senior neuro postdocs: SYNAPSES brings postdocs from around the world to Yale to share their work during an in-person symposium on October 23, 2025. Apply today to present your research, talk with faculty members in 1:1s, & interact with Yale postdocs! 🧠🧪 Deadline Sept 7. #neuroskyence

How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...

New paper from the lab, from Jeremy Biane and team, out today, characterizing the principles of stimulus feature coding in populations of ventral CA1 neurons.

It’s finally happening 🥹 save the date for our very first in-person event!! Fill out our interest form if you’ll be in SD for #sfn25 or otherwise, or fill it out even if you won’t be able to make it - we’re also gathering interest in a virtual streaming option!! Stay tuned for more details to come!!

Amidst everything, the lab's first preprint is out! It's just a methods paper, no scientific results (yet!), but it's still great to see it all pulled together. We hope that these open-source behavioral tools will be useful for others!

New cover "Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo" www.cell.com/neuron/fullt... #scArt #sciComm #neurons #neuroscience #neuroskyence

Excited to share our new preprint in which we propose a biologically plausible mechanistic solution to the problem of how the brain can flexibly learn and store new representations without forgetting previously learned information. www.biorxiv.org/content/10.1... Detailed 🧵 below 👇 1/12