Next up in the RSC Medicinal Chemistry Editor's Choice collection are Sally-Ann Poulsen's chosen articles! Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/11/1... And scan the QR code to see our collection as it grows👀

Thrilled to see our work on β-lactams and SARS-CoV-2 Mpro published in @rscmedchem.rsc.org! It’s been a pleasure contributing the computational modelling to this collaboration, which highlights how subtle chemical modifications can shift inhibition mechanisms. doi.org/10.1039/D5MD...

🔓Don't miss recent #OpenAccess work by Andrew G. Jamieson & co which reports the first lysine-targeting covalent inhibitors for malaria, showing promise for antimalarial drugs, as seen in our Kinases collection💡 pubs.rsc.org/en/content/a... 📍 @uofglasgow.bsky.social 🧪

As seen in our Kinases collection: Work by Partha Chakrabarti, Arindam Talukdar & co introducing a novel PROTAC-based strategy for the selective degradation of apoptosis signal-regulating kinase 1 (ASK1), a key mediator of MASH pathology. Read more here👇 pubs.rsc.org/en/content/a... 📍CSIR- IICB 🧪

Be sure to read this Review article by Selina Koch and Jürgen Bajorath which identifies and evaluates understudied protein kinases using biological and chemical criteria, featured in our Kinases themed collection⬇️ pubs.rsc.org/en/content/a... 📍 @unibonn.bsky.social 🧪

Check out this Review article by Mohamed S. Elgawish, Mohamed S. H. Salem & co on the advances in using artificial intelligence in the development of kinase inhibitors, as seen in our Kinases collection👇 pubs.rsc.org/en/content/a... 📍Suez Canal University and SANKEN The University of Osaka 🧪

📢We are delighted to share our latest themed collection on Kinases, guest edited by Hayley Binch, @heppnerd.bsky.social, Meizhong Jin and Philip Jones! Explore the articles that make up this fantastic collection, here👇 pubs.rsc.org/en/journals/... #chemsky 🧪

Time is running out to nominate for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship❗ ⌛Make sure you make your nomination before 31 October 2025! Find out how, here: www.rsc.org/standards-an... #chemsky 🧪

🔓Explore recent #OpenAccess work by @keanelab.bsky.social and colleagues where they describe a virtual screening approach to explore the druggability of the precursor structure of microRNA-31👀 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00553a 📍 @umich.edu 🧪

Had a great couple of days at #ELRIGDD25 representing @rscmedchem.rsc.org 💊 It was a great opportunity to chat with the drug discovery community about our journal and catch up with our Editorial Board members @lynjoneschembio.bsky.social and Sankar Guchhait in a briefly sunny Liverpool!

Have you submitted your nomination for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship yet⁉️ It’s open to any early-stage researcher working independently in the field of medicinal chemistry. More info here: www.rsc.org/standards-an... Nominations close 31 October 2025⌛ 🧪

Check out work by Raghu Raj, Vipan Kumar on the synthesis and anti-plasmodial profiling of oxalamide-linked 4-aminoquinoline-phthalimide hybrids👇 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00425j 📍Guru Nanak Dev University, Amritsar and DAV College 🧪

Don't miss recent work by Hao Wang, Xuehui Zhang, Jie Xia & co on using computer-aided drug design strategy to identify triazolothiadiazoles as DYRK1A-inhibitors for neuroprotective agents👏 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00289c 📍Shandong First Medical University and PUMCH 🧪

🔓Read this #OpenAccess Review by @moorelab.bsky.social and colleagues which explores the historic and recent progress in the discovery of small molecule drugs for Ebola virus disease⬇️ pubs.rsc.org/en/content/articlelanding/2025/md/d5md00533g 📍University of Illinois Chicago 🧪

Take a look at this Opinion article by Mike Hann which discusses the emerging opportunities in the rewiring of biology through proximity inducing small molecules💡 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00608b 🧪

On the front cover of issue 10 is work by Yosuke Demizu and colleagues on analysing the linker rigidity and improve intracellular behaviour of three novel PROTACs targeting H-PGDS, read more here👇 pubs.rsc.org/en/content/a... 📍National Institute of Health Sciences, Kanagawa 🧪

We are delighted to share our new collection: Highlights from Industry👀 Bringing together recent research and reviews by researchers in industry or as part of collaborations, we celebrate the innovations and discoveries from industry. Explore the collection so far👉 pubs.rsc.org/en/journals/... 🧪

🔓Check out this #OpenAccess Review article by Phanindra Kumar, Poulomi Sengupta and Sudipta Basu discussing small-molecule probes for imaging and impairing the Golgi apparatus in cancer 👏 pubs.rsc.org/en/content/a... 📍IIT Gandhinagar and Indrashil University 🧪

📢Calling all medicinal chemistry researchers from academia and industry 📢 Nominations for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship are open, and we’re excited to receive them! Deadline to nominate is 31 October 2025 ⏰ More info here: www.rsc.org/standards-an... #chemsky 🧪

Take a look at work by Jin-Bu Xu, Feng Gao & co on the synthesis and anti-proliferative activity of 3-aryl-evodiamine derivatives⬇️ pubs.rsc.org/en/content/a... 📍Southwest Jiaotong University 🧪

Don't miss recent work by @ritika7gautam.bsky.social & co on the development of next-generation gold(I)-NHC anticancer agents, particularly for treating apoptosis-resistant lung cancers👏 pubs.rsc.org/en/content/a... 📍IIT Kanpur 🧪

Be sure to read the latest work by Martin Hemmerling and colleagues where they optimised a series of BET PROTACs towards inhaled route of delivery furnished PROTACs with a picomolar degradation potency and full BRD4 degradation💡 pubs.rsc.org/en/content/a... 📍 @astra-zeneca.bsky.social 🧪

🔓Explore this #OpenAccess Review article by Ana Jug and Janez Ilaš which focuses on ATP-competitive inhibition in cancer therapy beyond kinases, highlighting recent advances and challenges in the field👇 pubs.rsc.org/en/content/a... 📍University of Ljubljana

We are delighted to announce that Professor Christina Chai from National University of Singapore has joined the RSC Medicinal Chemistry Editorial Board as an Associate Editor🎉 Read our blog post to find out more about Christina 👉 rsc.li/4pJ88oR #chemsky 🧪

Do you know an early career researcher working independently in the field of medicinal chemistry and drug discovery⁉ Why not nominate them for our 2026 Emerging Investigator Lectureship! Nominations close 31 October 2025🚨 More details here: www.rsc.org/standards-an... 🧪

Be sure to read the latest work from Kazuya Matsuo, Nobuyuki Tamaoki & co on report a photoswitchable CENP-E inhibitor that is controllable with low-energy blue-green light illumination, seen in our Photoswitches & Photopharmacology collection💡 pubs.rsc.org/en/content/a... 📍Hokkaido University 🧪

🔓Read #OpenAccess work by Sergii Afonin, Igor V. Komarov & co on the in vitro evaluation of immunogenic potential of gramicidin S and photocontrolled analogues, in our Photoswitches & Photopharmacology collection💡 pubs.rsc.org/en/content/a... 📍Taras Shevchenko National University of Kyiv, @kit.edu 🧪

Work from Subhas Samanta and colleagues on photoswitchable Stat3 inhibitors and their anticancer activity against 2D/3D breast cancer cell cultures is featured in our Photoswitches & Photopharmacology collection, read more here👇 pubs.rsc.org/en/content/a... 📍 University of Calcutta 🧪

Be sure to read recent work by Maikel Wijtmans, Rob Leurs & co on the synthesis of photoswitchable desloratadine ligands for histamine H1 receptor photopharmacology, as seen in our Photoswitches & Photopharmacology collection💡 pubs.rsc.org/en/content/a... 📍 @vuamsterdam.bsky.social 🧪

🔓Check out this #OpenAccess Review in our Photoswitches & Photopharmacology collection by P. K. Hashim & co discussing recent progress of using photomedicine for approaches in precision medicine and unprecedented treatment methods💡 pubs.rsc.org/en/content/a... 📍Hokkaido University

Don't miss the Editorial for the joint collection on Photoswitches & Photopharmacology from the guest editors🔦🔽 pubs.rsc.org/en/content/a...

📢 @orgbiomolchem.rsc.org & @rscmedchem.rsc.org are delighted to share our latest themed issue on Photoswitches & Photopharmacology, guest edited by Martina Cacciarini, @nadjasimeth.bsky.social, Wiktor Szymanski & Andrew Woolley! #chemsky Explore the collection here🔽 pubs.rsc.org/en/journals/...

Take a look at this Review article by Katrine Qvortrup & co discussing advances in developing small molecules targeting three virulence categories, a promising strategy to combat antibiotic resistant infections👀 pubs.rsc.org/en/content/articlelanding/2025/md/d5md00272a 📍Denmark TU 🧪

🔓The front cover of issue 9 is #OpenAccess work by Khondaker Miraz Rahman, Chris Pepper & co on a PBD-based PROTAC selectively degrading NF-κB subunit for RelA/p65-dependent tumour treatments, read it here👀 pubs.rsc.org/en/content/a... 📍 @kingscollegelondon.bsky.social, @bsmsmedschool.bsky.social🧪

In case you missed it: Nominations for the 2026 @rscmedchem.rsc.org Emerging Investigator Lectureship are now open👀 ⌛Deadline for nominations is 31 October 2025! Details about how to nominate are here: www.rsc.org/standards-an... 🧪

We’re excited to announce that nominations for our 2026 Emerging Investigator Lectureship are now open📢 Details about how to nominate: www.rsc.org/standards-an... We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD. Nominate before 31 October 2025! #chemsky 🧪

🔓Check out recent #OpenAccess work by Nils Metzler-Nolte and colleagues on a facile synthetic route, using click-able azido linkers, for di-pyridyl-thiosemicarbazone antibody–drug conjugates💡 pubs.rsc.org/en/content/a... 📍 @ruhr-uni-bochum.de 🧪

This week I am attending the EFMC-ASMC in Porto, representing @rscmedchem.rsc.org If you see me, come and say hello 👋 and keep a look out for our flyers for more information on the journal! #efmcasmc

🔓Read recent #OpenAccess work by Daohong Zhou, Guangrong Zheng & co on the potential of CRBN-recruiting Bcl-xL degraders as promising anticancer agents with improved efficacy and manageable platelet toxicity🔥 pubs.rsc.org/en/content/a... 📍 @ufresearch.bsky.social 🧪

🔓Be sure to read this recent #OpenAccess work by Nils Metzler-Nolte & co: "Glycosidase-activated prodrugs of a cytotoxic iron chelator for targeted cancer therapy"👀 pubs.rsc.org/en/content/a... 📍@ruhr-uni-bochum.de 🧪

📢Highlight your work on the cover of RSC Medicinal Chemistry! We are looking for vibrant, eye-catching artwork to feature on our upcoming covers. Check out some of our previous covers and the benefits you receive for them👇 Interested in amplifying your research with a cover? Please let us know!

🔓Explore this #OpenAccess work by Herman Sintim, Jie Wu and colleagues on the identification of alkynyl nicotinamide HSN748 as a RET solvent-front mutant inhibitor with intracranial efficacy👇 pubs.rsc.org/en/content/a... 📍@notredame.bsky.social and University of Oklahoma Health Sciences Center 🧪

Next up in the RSC Medicinal Chemistry Editor's Choice collection are Cynthia Dowd's chosen articles! Be sure to read our blog to see what she chose and why 👉 blogs.rsc.org/md/2025/08/2... And scan the QR code to see our collection as it grows👀

🔓Be sure to read this #OpenAccess Review by Radek Indra and Věra Černá exploring the role of CFTR in cell growth and cancer development and the relationship between cystic fibrosis and the predisposition to certain cancers⬇️ pubs.rsc.org/en/content/a... 📍Charles University 🧪

Don't miss this Review article by Tom Barlow, Ilse Rooman and Steven Ballet which discusses the recent advances in targeting mitotic kinases in PDAC and the clinical and therapeutic perspectives for each category of kinases👏 pubs.rsc.org/en/content/a... 📍Vrije Universiteit Brussel 🧪

Check out this Opinion article by Nishant Nitinidhi Kulshreshtha and Philippe Barthélémy discussing how locked G quadruplexes could be the key to new modalities in nucleic acid therapeutics💡 pubs.rsc.org/en/content/a... 📍IISER, Pune and @univbordeaux.bsky.social 🧪

This month's inside front cover features work by Partha Chakrabarti, Arindam Talukdar & co exploring a PROTAC-based strategy for the selective degradation of apoptosis signal-regulating kinase 1, towards targeted therapy in MASH. Take a look👀 pubs.rsc.org/en/content/a... 📍CSIR-IICB 🧪

🔓On the front cover is #OpenAccess work by Sergii Afonin, Igor Komarov and colleagues on the in vitro evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues, read it here⬇️ pubs.rsc.org/en/content/a... 📍 @kit.edu and Taras Shevchenko National University of Kyiv 🧪

Issue 8 is now online and ready to read👇 pubs.rsc.org/en/journals/...

Don’t forget! The Tri-Institutional Chem Bio Symposium is Aug 28 🧬 Proudly sponsored by RSC ChemBio + ‪@rscmedchem.rsc.org‬! 🗓️ Reg closes Aug 20 🧪 Posters welcome from all attendees 📍 At ‪@mskcancercenter.bsky.social‬ Be there! #ChemBio #MedChem #ScienceSymposium #RSCJournals