🔓Don't miss this #OpenAccess review from Kagan Kerman & co. @chemuoft.bsky.social in our latest issue exploring the latest developments in modulators, antibody therapy and gene therapy targeting BACE1 #medchem Check it out in full on our website🔽 pubs.rsc.org/en/content/a...

📢 We are excited to announce this year’s Chemical Science symposium on the topic of digital chemistry in the age of AI and machine learning! Find out more at rsc.li/chemscisymp2026 The symposium will be held in London, UK on the 29th and 30th of October 2026 in person only. #ChemSciSymposium

📢Our latest issue is now online! Check out the research behind the cover by Paul Harris, Margaret Brimble, Alan Cameron & co. @aucklanduni.bsky.social introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B to combat Gram -ve pathogens #medchem pubs.rsc.org/en/content/a...

🔓Read #OpenAccess research by @smietana-m.bsky.social, @jeanyveswinum.bsky.social et al. @umontpellier.bsky.social in our latest issue harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases #medchem Find it in full here🔽

Don't miss research in our latest issue by @wmwuest.bsky.social, Kevin P. C. Minbiole & co. @villanovapr.bsky.social & @emoryuniversity.bsky.social investigating octenidine and isooctenidine analogs as potential disinfectants #medchem Check out the full article below👇

🔓Check out this #OpenAccess review by Xinuo Li, Zheying Zhu & co. from China Pharmaceutical University & @uniofnottingham.bsky.social in our latest issue discussing PROTAC-mediated multi-target protein degradation in Alzheimer's disease #medchem Read it in full here🔽

Take a look in our latest issue at research from Marcin Feder et al. on the design and biological evaluation of triagonist GLP-1R/GCGR/GIPR peptides as potential therapeutic agents for diabetes and obesity #medchem 📍Adamed Pharma

🔓Read this #OpenAccess review from Antonios Kolocouris et al. at the University of Athens in our latest issue looking at the structure-based design, biological evaluation & synthetic approaches for adamantane-based inhibitors of influenza A #medchem Find in full here🔽

Don't miss research in our latest issue from Angel H. Romero, Hugo Cerecetto & co. at Universidad de la República reporting in vitro and in vivo studies of dehydroxylated-isoquines and -isotebuquines against trypanosomatids #medchem Check it out on our website👇

🔓Check out a #OpenAccess paper by @stevehusbands.bsky.social et al. from @uniofbath.bsky.social & @umich.edu in our latest issue describing the synthesis & evaluation of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydromorphinone derivatives #medchem Read it here🔽

Take a look in our latest issue at research from Henrik Franzyk & co. reporting novel scaffold-based peptidomimetics as potential antibacterial agents #medchem 📍University of Copenhagen, @uio.no

🔓Be sure to read this #OpenAccess review by Qian Chu et al. from China Pharmaceutical University in our latest issue discussing peptides as multifunctional linchpins in targeted drug conjugates #medchem Find the full article on our website🔽

Don't miss research behind the inside front cover of our latest issue by Monalisa Mukherjee, Brajendra K. Singh, Virinder S. Parmar & co. at University of Delhi reporting biocompatible de novo indolylchalcones as potential cardiovascular & wound-healing agents #medchem pubs.rsc.org/en/content/a...

⏳Only one week left until registration for the Medicinal Chemistry Summer School 2026 closes on 8 May! #medchem ❗Act now to secure your place on an exciting five-day programme of hands-on tutorials and lectures from leading experts in drug discovery. Register now: invt.io/1bxb8q8mdr1

📢Our latest issue is now online! Check out the research behind the front cover by Moustafa T. Gabr & co. @weillcornell.bsky.social using DNA-encoded library screening to discover a CHI3L1-targeted small molecule modulating neuroinflammation in Alzheimer's #medchem pubs.rsc.org/en/content/a...

🔓Take a look in our latest issue at this #OpenAccess paper by Anna K. H. Hirsch et al. reporting the design and optimization of simplified inhibitors targeting Escherichia coli and Klebsiella pneumoniae IspE #medchem 📍 @helmholtzhips.bsky.social

Be sure to read research from Zuojin Liu et al. at Chongqing Medical University in our latest issue describing how Kupffer cell M2-like polarization increases liver metastatic burden via the uptake of exosomal KRAS mutant protein #medchem Find it in full here🔽

Don't miss this Opinion article in our latest issue by Susanta Samajdar at Aurigene Oncology Ltd. providing a dialogue on innovation in anticancer drug discovery #medchem Check it out in full below👇

🔓Check out a #OpenAccess paper from @cjserpell.bsky.social, @shepherdlabkent.bsky.social & co. at @kent.ac.uk & @ucl.ac.uk in our latest issue investigating how madecassic acid inhibits bacterial respiration #medchem Read their full report on our website🔽

Take a look in our latest issue at research from Timo Heinrich et al. using phenotypic screening hit optimization to develop the CNS penetrant TEAD1,2,4 inhibitor MSC-4070 #medchem 📍 @merckgroup.bsky.social

⏳There is only one week left to get your early bird registration for the Medicinal Chemistry Summer School 2026! #medchem Don't miss your chance to increase your understanding of the factors governing modern drug discovery Register now: invt.io/1bxbmhriegz

Be sure to read this review by Zunyuan Wang & co. at Hangzhou Medical College in our latest issue covering recent progress in the design, optimization and potential applications of METTL3 inhibitors as cancer therapeutics #medchem Find it in full here🔽

Don't miss in our latest issue this paper from Haytham O. Tawfik et al. at Tanta University exploring pyrazoline-thiophene hybrids as CDK2 inhibitors #medchem Check it out in full below👇

🔓Check out #OpenAccess research by Iwan J. P. de Esch & co. @vuamsterdam.bsky.social in our latest issue leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands for the histamine H1 receptor #medchem Read their full report on our website🔽

Take a look at this review in our latest issue by Jian Zhang, Mingliang Wang et al. providing a perspective on SIRT3 modulators in disease treatment #medchem 📍Shanghai Institute of Materia Medica, Shanghai Jiao Tong University

🔓Be sure to read this #OpenAccess paper by Susanna H. Wood & co. @unistrathclyde.bsky.social in our latest issue reporting efficient log P determination by automated, spatially encoded 19F NMR spectroscopy #medchem Find it in full on our website👇

🔓Don't miss the #OpenAccess research behind the inside front cover of our latest issue by Maria L. Di Gioia et al. from the University of Calabria presenting the integration of green synthesis and liquid–liquid extraction of lidocaine in deep eutectic solvents #medchem pubs.rsc.org/en/content/a...

📢Our latest issue is now online! Check out the review behind the cover by Konrad Kowalski & co. from University of Łódź looking at ferrocenyl ferroptosis inducers as an emerging class of anticancer agents #medchem pubs.rsc.org/en/content/a...

Be sure to read this review from Tu M. Ho & Francis K. Yoshimoto @utsaroadrunners.bsky.social in our latest issue discussing strategies to inhibit steroid cytochrome P450 enzymes to benefit human health #medchem🧪 Find the full article here🔽

🔓Check out this #OpenAccess research by Matthias Schild & Dennis Gillingham @unibas.ch in our latest issue exploiting intracellular oncogenic proteins for the intracellular delivery and release of cytotoxins #medchem🧪 Read it in full on our website🔽

📢We are delighted to announce that @fleurmferguson.bsky.social (@ucsandiego.bsky.social) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship! Please join us in congratulating her 🎉 #medchem #chemsky Find out more about Fleur here🔽 blogs.rsc.org/md/2026/03/1...

Take a look at this review in our latest issue from David Rudd, Manuela Jörg & co. discussing strategies for for early screening of pharmaceutical persistence, toxicity and bioaccumulation using in silico and analytical tools #medchem🧪 📍 @monashuniversity.bsky.social

Read research in our latest issue from Yuheng Yang, Xiaoyong Xu et al. from East China University of Science and Technology using a stacking-based machine learning model to guide discovery of novel polymyxin E adjuvants against A. baumannii #medchem 🧪 Find it in full🔽

🔓Don't miss this #OpenAccess Opinion article, part of our Sustainable Medicinal Chemistry collection, by @mlbolognesi.bsky.social & co @unibo.it providing their personal experience on the many facets of sustainability in medicinal chemistry #medchem 🧪 Check it out here👇

📢Know someone worthy of the @rscbmcs.bsky.social Hall of Fame? Nominations are open for the 2026 inductee recognising a prominent chemist for outstanding, sustained contributions to areas of interest to the BMCS #chemsky #chembio #medchem Find out how to nominate🔽 www.rscbmcs.org/awards/hallo...

🔓Check out #OpenAccess research from Hwan Jung Lim, Seong Jun Park et al. at KRICT in our latest issue describing N-cyano sulfoximine-mediated thiazole ligation with N-terminal cysteine under mild aqueous conditions #medchem 🧪 Read their full report on our website🔽

🔓Take a look in our latest issue at #OpenAccess research by Sigrid Lacaille & Andreea R. Schmitzer reporting mitochondria-targeting symmetric diiminoguanidines as potent and selective anticancer agents against pancreatic tumors #medchem 🧪 📍 @umontreal.ca

Read this review, part of our 5th Anniversary collection, by Shams Aaghaz, Ahmed Kamal et al. at BITS Pilani in our latest issue providing an overview of recent advancements in targeted cancer therapies & their potential clinical impact #medchem 🧪 Find it in full below👇

📢We are delighted to announce our #OpenCall for papers to our Macrocyclic Peptide & Peptidomimetics themed collection #chemsky #medchem Guest Editors: Sandro Cosconati, Cameron Pye, @danithechemist.bsky.social & Philip Thompson Deadline: 31st July 2026 Find out more🔽 www.rsc.org/publishing/j...

🔓Don't miss this #OpenAccess paper in our latest issue by @andysuth14.bsky.social & co @uofgchem.bsky.social & @edinburgh-uni.bsky.social on the synthesis of enantiomeric quinoline-2-carboxamides as PET imaging agents for the translocator protein #medchem Check it out🔽

📢Our latest issue is now online! Check out the review behind the cover by @sculpturatus.bsky.social & co. at @uarizona.bsky.social looking at the history, synthesis and medicinal use of cantharidin, LB-100, and their analogs #medchem pubs.rsc.org/en/content/a...

Take a look at research in our latest issue by Jeffrey M. Axten & co. on the discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors #medchem 🧪 📍 @gsk.bsky.social

Read research reporting how novel small molecule derivatives improve survivability in the cellular model of Huntington's disease via improving mitochondrial fusion by Tanmay Chatterjee, Shuvadeep Maity et al. from BITS Pilani in our latest issue #medchem 🧪 Find in full🔽

Don't miss this review in our latest issue by @rutledgends.bsky.social, Louis M. Rendina et al. at @sydney.edu.au highlighting the recent advances and medical chemistry opportunities of boron cluster compounds #medchem 🧪 Check it out in full below👇

🔓Check out #OpenAccess research by John C. Vederas & co. from @ualberta.bsky.social in our latest issue exploring pharmaceutical potential of retro-inverso apelin peptides, part of our 5th Anniversary collection #medchem 🧪 Find in full on our website🔽

Take a look in our latest issue at research from Natalia P. Alza, María Belén Faraoni et al. describing the synthesis and evaluation of lupeol-derived triterpenic azines as potential neuroprotective agents #medchem 🧪 📍Universidad Nacional del Sur

🔓Be sure to read this #OpenAccess article from Philip Reigan et al. @cuanschutz.bsky.social investigating the structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition #medchem 🧪 Find their full report👇

Don't miss research by Yu Zhang, Jun Luo & co. at Nanjing University of Science & Technology in our latest issue using peripheral tailoring of pentacene to develop next-generation organic sonosensitizers for cancer sonodynamic therapy #medchem 🧪 Check it out here🔽

Check out research by Trevor J. Kilpatrick, Jonathan B. Baell et al. from @monashuniversity.bsky.social reporting fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development #medchem 🧪 Read in full below👇

🔓Take a look in our latest issue at this #OpenAccess review by Franck Amblard, Raymond Schinazi & co. providing an overview of prodrug strategies in developing antiviral nucleoside analogs #medchem 🧪 📍Emory University