📢DNA templates are no longer required for efficient nucleic acid ligation. 💡We introduce Charge-Transfer Assisted Ligation (CTAL): a new templated reactivity based on π-stacking donor–acceptor interactions (DAN/NDI), not base pairing. 📄 chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.10

Be sure to read research from Guillaume Clavé, @smietana-m.bsky.social & co. at @umontpellier.bsky.social on the synthesis, duplex-forming properties and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages #orgchem Find the full report here🔽

Had a great day visiting Francoise Debart and Michael Smietana @smietana-m.bsky.social at IBMM in Montpellier. 😊 Thank you for the invitation, the hospitality and the scientific discussions. 🧬🤩

Our lastest article has just been released (Org. Biomol. Chem): Synthesis, duplex-forming properties, and enzymatic resistance of oligonucleotides containing N-acylsulfonamide linkages pubs.rsc.org/en/content/a... @chembionac.bsky.social @umontpellier.bsky.social @cnrs.fr @ibmm-balard.bsky.social

Very happy to share our latest publication on the Synthesis and Base-Pairing Properties of Oligonucleotides Containing 5′-(R)- and 5′-(S)-C-Aryl-thymidine now in JOC pubs.acs.org/doi/10.1021/... @chembionac.bsky.social @cnrs.fr @umontpellier.bsky.social @ibmm-balard.bsky.social

We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)! Published in @chemicalscience.rsc.org Led by Disha Kashyap #chemsky 🧪 pubs.rsc.org/en/content/a...

Our work on Enantioselective Artificial PhotoDNAzyme now live on ChemRxiv tinyurl.com/mwtpd96u Our work merges synthetic transition-metal photocatalysis with the chiral environment of DNA to achieve visible-light-driven, enantioselective [2+2] cycloadditions.

The Institute of Biomolecules Max Mousseron (ibmm.umontpellier.fr) invites applications for 2 CNRS tenure-track positions. -> Glycochemistry -> RNA Chemistry contact : [email protected] To apply: carrieres.cnrs.fr/recrutement-postes-de-chaires/

WE RECRUIT: 18-month post-doctoral position + attractive salary + institutional support and training for grant applications. Research topic: dynamic combinatorial chemistry, peptides, and mechanochemistry. @ibmm-balard.bsky.social @umontpellier.bsky.social @fredlamaty.bsky.social

Two of our innovations, KapdiPhos and SerrKap palladacycle are now commercialised and are available from leading chemical vendors such as Merck, Strem, BLD Pharm and TCI. kapdigroupresearch.com

📢 Postdoc Opportunity: - main-group and @Boron-chemistry.bsky.social, - ERC project "B-YOND" @erc.europa.eu, - University of Namur, Belgium. 🇪🇺 Join us at the chemistry institute in a dynamic and supportive environment ! ⏳ Deadline: 15. April 2025. ⤵️ Link to apply: euraxess.ec.europa.eu/jobs/323190.

Very exciting scientific day on the occasion of Jean-Jacques Vasseur' retirement. Thanks to the speakers and thanks to all the participants. Happy retirement jacques !🌴🚴🥂 @umontpellier.bsky.social @chembionac.bsky.social @ibmm-balard.bsky.social

Fantastic lectures on photo-biocatalysis, transition-metal catalysis and organocatalysis at @UNamur.bsky.social chemistry department. Great dissussions with @GrimaudLaurence (ENS Paris), @smietana-m.bsky.social (Univ Montpellie), E McGarrigle (@McGarrigleGroup, UCDublin) and @OlivierRiant.

Mini-symposium at the chemistry department of @UNamur.bsky.social this Friday. Three invited speakers: Prof. Smietana (@Smietana-m.bsky.social), Grimaud (@Grimaud-Laurence.bsky.social) and McGarrigle (@McGarrigleGroup.bsky.social). Looking forward to welcome you and talk about chemistry!

Recent Development of DNA‐based Biohybrid Systems Driven by Light 👉https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202401297 @chembionac.bsky.social @ibmm-balard.bsky.social @chemistryeurope.bsky.social @umontpellier.bsky.social

Zachary Pastorel has successfully defended his PhD thesis on DNA-based asymmetric catalysis. Congrats Zach ! Many thanks to the committee members @borisvauzeilles.bsky.social Olivier Baslé, Marine Desage Sami Lakhdar @umontpellier.bsky.social @chembionac.bsky.social

Open position : Junior Professorship in Chemical Biology / RNA chemistry Please DM for more info @cnrs.bsky.social @umontpellier.bsky.social