Only a few days left to apply for this PhD opportunity in my lab! More details and how to apply at: www.findaphd.com/phds/project...

This alternative view of “condensate” biogenesis is compatible with everything that LLPS claims for itself, including the apparent liquid-like behavior that people a bit ignorant of dynamics find so exciting. I explained this here www.embopress.org/doi/full/10....

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

70 teaspoons placed in tearooms around the institute & observed weekly over 5 months. 80% of spoons disappeared; spoon halflife~81 days. Communal room halflife lower than in specific labs. 250 spoons annually required to maintain 70 spoon population. pmc.ncbi.nlm.nih.gov/articles/PMC...

The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It… 1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.

I’ve been offline for a while for the reason below. But I’m back in the lab, with more motivation and joy than ever before! The last year has been a wild ride, but everything has worked out brilliantly!

Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology: www.ebi.ac.uk/training/onl... Including both molecular and epidemiological examples

It's more important than ever for students and educators to stay informed and proactive. That's why you're invited to our upcoming webinar “The Future of Graduate Education in Biophysics" September 4, 3:30-5:00PM USA Eastern my.biophysics.org/events/calen...

Starting off our NAF 2025 meeting with an introduction of the RSC Nucleic Acids Group's new chair, Marco Di Antonio! An exciting new era for our group begins! 🧬 @diantoniogroup.bsky.social

This is a proper tour de force of integrative structural biology and biochem! (Including from our own @eecutts.bsky.social @mcb-sheffield.bsky.social) so many crucial roles for SLiMs in fundamental cellular processes.

Condensin II activation by M18BP1: Molecular Cell www.cell.com/molecular-ce...

JOB OPENING for biochemist/-physicst 🧑‍🔬: This isn't an official job ad yet. We are looking for a postdoc working on large to high throughout single-molecule FRET on protein structures and dynamics. The project will be run in our lab and co-directed jointly with a team from big pharma/biotech. 1/2

Job Alert 🔊🔊 Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy

Looking for a senior lecturer (associate #professor) position in #biochemistry? Come and join our neighbouring department at Uppsala University: www.uu.se/en/about-uu/...

Less than two weeks to go! Thanks for all the donations! www.justgiving.com/team/thalia

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Fantastic new work on substrate recognition by separase! www.biorxiv.org/content/10.1...

Anyone looking for a PhD: the second deadline of the Yorkshire DTP closes this Friday, the 14th. Get in touch asap if you are interested in working with me on condensin complexes! www.findaphd.com/phds/project...

Deadline for abstract submission (for poster/short talk presentation) extended until March 14 - after that we will open registration for scientific participants without abstracts.

Another fave

Very happy to see this out! 😍 Tissue-like lipid networks with motile bacteria undergo large remodeling events, leading to active “hubs” & tissue fluidization! This was a super fun collab w Jan Steinkuhler lab! www.nature.com/articles/s41...

Don’t miss the early bird registration for this exciting meeting focused on neglected areas of genetics, cellular and structural biology. Lots of slots for speakers selected from abstracts. 2-4 April 2025 in Edinburgh.

Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details

Our first introductory episode will go live tomorrow! @timcoulson.bsky.social @sykhalid.bsky.social @streamingspires.bsky.social scienceofthetimes.transistor.fm

Happy to report our enzyme found a home! rdcu.be/eaGXG New kid on the block P450 O-demethylase SyoA-the specificity of a monooxygenase with the simplicity of catalysis driven by peroxide. Retrofit your P450 with this active site chemistry today! #lignin #syringol Out today in Nature Communications.

There are certainly worse office views

The UK&Ireland single-molecule meeting 2025 will be held in Oxford on May 14 and 15 - deadline for abstract submission March 7 - submit one and join us! Here is the link: lumicks.com/uk-single-mo...

Beautiful work showing how DSBs trigger de novo cohesin loops, positioned perfectly at break sites. RAD51 spreads ~Mb within TAD limits & loop extrusion actively drives homology search - distant HR repair drops when you kill cohesin loading by NIPBL! #DNArepair www.biorxiv.org/content/10.1...

Check out our journey to #BPS2025 See you there at Booth 410! Still a limited number of tickets for our happy hour available so come by the booth!

I play this fun game with my husband in the lead up to valentines where we joke about getting each other gifts/cards with the understanding that we do not do anything for Valentine’s Day. One day one of us might ruin it and buy something romantic, but for now it’s a fun game.

At #EMBOinsitu and looking for a motivated postdoc joining an interdisciplinary project in my lab: jobs.icr.ac.uk/vacancies/11... the-alfieri-lab.co.uk #cryoem #cryotem

I had a wonderful time presenting and talking to everyone at the University of Leeds! Thanks so much for hosting @qianwu5000.bsky.social

For anyone that was too busy at the end of last year to think about PhDs or are still looking for the right project/place, I have a project available in the second round of the Yorkshire Biosciences DTP scheme looking at the dynamics of human condensin: www.findaphd.com/phds/project...

My lab is #hiring! I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism. www.jobs.ac.uk/job/DLO693/r... www.jobs.ac.uk/job/DLP016/r... #Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS

EMBO Workshop – DNA topology and topoisomerases in genome dynamics. 15-19 September 2025 Szklarska Poręba, Poland REGISTRATION NOW OPEN Interested in attending? Visit the website: meetings.embo.org/event/25-dna... Register by: 15 March 2025

I'm excited to announce the 2025 Royal Society of Chemistry's Nucleic Acid Forum will take place on 11th July at Burlington House, London! Booking open's soon! @roysocchem.bsky.social @drzoewaller.bsky.social @diantoniogroup.bsky.social @yiliangding.bsky.social www.rsc.org/events/detai...

Re-upping this opportunity while the application window is still open!

Ummm, what? Unbelievable…

This looks like a great meeting!

📣 #EMBLSingleMolecule is open for registrations! Our aim is to catalyse the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma. 🧬🔍 👉🏼 s.embl.org/grg25-01-bl 📅 15 – 18 July 2025 📜 Submit your abstract by 8 April!

This sounds like a brilliant scheme, particularly for young scientists wanting to see the world and building an international network!

PhD Opportunity! Apply multiomics approaches to uncover how plants maintain fertility under heat stress. We're looking for enthusiastic applicants passionate about plant science! 🌾🧬🔬 Apply: bit.ly/TempResilien... Deadline: 03.02.2025 #PhDPosition #PlantScience #CropImprovement

“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽‍🔬

Reminder that @arianebriegel.bsky.social compiled a nice list of women in #cryoEM . I often get asked to recommend people and this is a great place to start 😀 briegel-lab.org/women-in-cry...

Two more weeks to apply to our opening for a senior postdoc in biophysics; work on exciting projects in DNA replication and/or chromatin organization from an interest in instrumentation! Deadline Jan 15 and application link: my.corehr.com/pls/uoxrecru...

If your new year resolution is doing a PhD, there is still time left to apply for a project in my group looking at how the condensin complex undergoes such large conformational changes while making loops. I mean look at how cool the starting model is: