New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

Our Spring PhD call is OPEN! 30+ fully funded positions in diverse life science disciplines. Explore projects in Biochemistry, Biophysics, Structure: www.vbcphd.at Apply by 9 April Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...

Apply to the scientific programmer/bioinformatician position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/scientific-programmer-bioinformatician-gerlich-lab #research #jobs #europe #biology

We are hiring! Join the Gerlich lab as a scientific programmer/bioinformatician and join an interdisciplinary team studying fundamental mechanisms of chromosome organization, DNA repair, and cell division.

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

1/ New preprint alert! In collaboration between the Rosen, Redding, Collepardo-Guevara & Gerlich labs, we uncover a surprising principle of chromosome organisation: electrostatic repulsion positions centromeres at the chromosome surface during mitosis. 🔗 doi.org/10.1101/2025...

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025...

1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! www.biorxiv.org/content/10.1...

New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social! How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair! Read more 👉 https://doi.org/10.1101/2025.02.10 Follow along for key insights! 🧵

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...