Beautiful work from James Li’s lab, out in @natneuro.nature.com, dissecting the role of FOXP genes [mostly, FOXP1 and FOXP2] in regulating Purkinje cell diversity and cerebellar hemisphere developnent 🧪🧠🧬 www.nature.com/articles/s41...

Sarah characteristically turning a bonkers story into a fascinating one.

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Happy 99th birthday to the man who gave voice to the wild. 🎉 Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace. You've inspired generations to fall in love with nature.

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Great study by @nataliabaumann.bsky.social @djabaudon.bsky.social & collaborators, showing how regional differences in progenitor metabolism shape brain growth during development @cp-cell.bsky.social www.cell.com/cell/abstrac...

🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...

It’s been a hectic few days, here’s a quick thread on our latest endeavour exploring GABAergic neurogenesis in the human cerebellum published in @pnas.org. Key takeaways: Purkinje cells are born very early in human development — much earlier than previously appreciated. www.pnas.org/doi/10.1073/...

Inspired by Cajal, the Hansel lab’s new work in @eLife provides a comparative histological analysis of human and mouse Purkinje cell morphology. Following our 2023 study, we detail differences of scale and kind between the neurons of the two species 🧵⬇️ elifesciences.org/articles/105...

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

Please be a kind and considerate reviewer, even if you have criticism (think of the first author who poured their heart and soul into the work). Also, read the paper or revisions and make sure you don't suggest experiments that are already in the manuscript... 😂

Great paper by @noonanlab.bsky.social, now out in Cell, on the role of “human accelerated regions” in human brain evolution; showing they altered the expression of ancestral gene targets shared between human and chimpanzee rather than by gained new targets in human 🧪🧠🧬 www.cell.com/cell/abstrac...

Someone in 1st Century India got human embryonic limb development perfectly right. The progressive emergence of parts, even the timing, exactly right. Today, I'll start a new thing about the ancient origins developmental biology, the science of embryos. 🧵1/15 #TheLongBibliography #DevBiol #SciHist

It's becoming increasingly apparent that people with knowledge need to respond quickly and forcefully in the face of false rumors. (Recent "drone" hysteria in New Jersey is just one example.) Here, Nicole Rust on the necessity of scientific outreach in 2025: www.thetransmitter.org/craft-and-ca...

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip www.nature.com/articles/s41...

Excited to announce the publication of our team's work suggesting a new framework for understanding hashtag#synapse hashtag#development and diversity in the mammalian hashtag#brain in Nature Neuroscience rdcu.be/d2100 🧵

We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social

Latest paper in Nature this week: an atlas integrating 36 single-cell datasets spanning 26 protocols for making neural #organoids Effort led by B. Treutlein, @fabiantheis.bsky.social and @graycamplab.bsky.social

Annual morbidity in the 20th century, before and after vaccines: Measles: Before: 530,000, After: 47 Mumps: Before: 160,000, After: 429 Rubella: Before: 50,000, After: 3 Diphtheria: Before: 20,000, After: 2 Smallpox: Before: 30,000, After: 0 Polio: Before: 16,000, After: 0

I'm thrilled to announce that the review I wrote with @brainevodevo.bsky.social is now online @Nature Review Neuroscience: www.nature.com/articles/s41... We cover mechanisms of prolonged human neuronal maturation, integrating lessons from model organisms with studies on species differences.

Nice new #brainorganoid preprint from @knoblich-lab.bsky.social, providing evidence for generation of large portionsof fetal brain cells across several pluripotent stem cell lines, across 4 protocols. Very valuable resource for the field:

Hi Bluesky 🧪🧠, Let me introduce my second postdoctoral piece published a couple of weeks ago, under the direction of @vanderhaeghenp2.bsky.social, with @franckp.bsky.social and Cécile Charrier, in #Neuron @cellpress.bsky.social 🧵: doi.org/10.1016/j.ne... #neuron #neoteny #human #SYNGAP1