Evolution of oncogene amplification across 86,000 cancer cell genomes www.biorxiv.org/content/10.6...

doi.org/10.1016/j.aj... Dominant and recessive ATOH1 variants cause distinct neurodevelopmental disorders with hearing loss

Another great paper from @ckadoch.bsky.social lab, congrats! doi.org/10.1126/scie...

Somatic evolution following cancer treatment in normal tissue www.nature.com/articles/s41...

RNA-binding proteins mediate the maturation of chromatin topology during differentiation www.nature.com/articles/s41...

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do www.cell.com/neuron/fullt...

Cell-type-specific enrichment of somatic aneuploidy in the mammalian brain www.cell.com/neuron/fullt...

www.biorxiv.org/content/10.1... SRRM1 coordinates an alternative splicing program that promotes expression of oncogenic protein isoforms

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice www.nature.com/articles/s41...

Large-scale discovery of chromatin dysregulation induced by oncofusions and other protein-coding variants www.nature.com/articles/s41...

Gene context drift identifies drug targets to mitigate cancer treatment resistance www.cell.com/cancer-cell/...

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis www.biorxiv.org/content/10.1...

🧪 New paper alert! In new work led by Adele Mossa out now in @natcomms.nature.com, we find that the #autism risk gene #DDX3X is a critical regulator of sexual dimorphisms in neuronal neurodevelopment 🧬 🧠 www.nature.com/articles/s41...

Radiation-induced amphiregulin drives tumour metastasis doi.org/10.1038/s415...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

📆 5-6 juin 2025 : Paris Kids Cancer, co-dirigé par l’ @ap-hp.bsky.social , @gustaveroussy.fr, l’Institut National du Cancer et l’Institut Curie, organise son 1er symposium sur le système immunitaire chez l'enfant et sa dysrégulation ℹ️ plus d'information : curie.fr/symposium-paris-kids-cancer-2025

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressure www.cell.com/cell-reports...

Spatial mapping of transcriptomic plasticity in metastatic #PancreaticCancer 🧪 www.nature.com/articles/s41...

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth www.nature.com/articles/s41...

Congratulations @haldipur.bsky.social, It's great to see it out! 🧠 Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum doi.org/10.1073/pnas...

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

🔴 Dans un entretien à @lexpress.bsky.social, Yasmine Belkaid DG @pasteur.fr, Bana Jabri DG @institutimagine.bsky.social et Alain Puisieux, Pdt du Directoire de l’Institut Curie, lancent un appel pour défendre la #science face aux menaces qui pèsent sur elle. ➡️ www.lexpress.fr/sciences-san...

The path to leptomeningeal metastasis www.nature.com/articles/s41...

✨So happy to see part of my PhD work with @lippilab.bsky.social out today in @cp-neuron.bsky.social! ✨ We developed new tools to study microRNA-target networks with greater spatial and temporal resolution and found neuronal subtype- and developmental stage-specific roles:

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors doi.org/10.1016/j.im...

Cool feature, let's try it! Thanks to @sjgreenwood.bsky.social and @nkgarg.bsky.social

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Intrinsic electrical activity drives small-cell lung cancer progression www.nature.com/articles/s41...

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements Really excited to see this fascinating work on @biorxivpreprint.bsky.social! Huge congrats to Ashu and Anindya and the entire team for this masterpiece, bravo! www.biorxiv.org/content/10.1...

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. https://go.nature.com/41a7Zzj

NOVA1, a neuron-specific RNA binding protein & splicing factor, likely impacted language function in human evolution. Human NOVA1 is unique (vs mammals, Neanderthals), & it changes vocalization in CRISPR’d mice! TY @NatureComms @RockefellerUniv team, collaborators @erichjarvis @asiepel labs 🧵👇

Developmental Origins and Oncogenesis in Medulloblastoma www.annualreviews.org/content/jour...

Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...

ProtGPS: Protein codes promote selective subcellular compartmentalization www.science.org/doi/10.1126/...

🔥 Quantifying cell divisions along evolutionary lineages in cancer www.nature.com/articles/s41...

Proud to share this preprint on behalf of Nico, Daren and team with some insights that we hope will be helpful to those modeling K27M mutations in histone proteins. #BandoLab www.biorxiv.org/content/10.1...

The NIH Sexual & Gender Minority Research Office website has been taken down. LGBTQ+ people are disproportionately subjected to violence, discrimination & stigma, affecting their health outcomes. Ignoring these facts endangers us all. #MedSky #LGBT #LGBTQ #NIH #research #science

😦 😦

Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity www.nature.com/articles/s43...

🚨 We are hiring! We are looking for motivated bioinformatician to join our team “Genomics and Development of Childhood Cancers" at Institut Curie, Paris, France. The interested candidates should apply by sending an email with their CV and motivation letter

High cellular plasticity state of medulloblastoma local recurrence and distant dissemination www.cell.com/cell-reports...

It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!

Cancer statistics, 2025 acsjournals.onlinelibrary.wiley.com/doi/10.3322/...

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: @danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org www.science.org/doi/10.1126/...

Molecular and cellular dynamics of the developing human neocortex www.nature.com/articles/s41...

🚨 We are hiring! We are looking for motivated bioinformatician to join our team “Genomics and Development of Childhood Cancers" at Institut Curie, Paris, France. The interested candidates should apply by sending an email with their CV and motivation letter

ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip www.nature.com/articles/s41...

Delighted to highlight our new paper in @natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...