My lab website has launched!! sites.dundee.ac.uk/wataru-kobay...

I am excited to have been awarded a Wellcome Trust CDA fellowship. This award allows us to dissect the mechanistic basis for trophectoderm lineage commitment across scales, from atoms to embryos. I will start the recruitment for several positions. Stay tuned! www.dundee.ac.uk/news/wellcom...

This is a fascinating historical account of RecA-mediated D-loop formation. I was particularly surprised to learn that Meselson and Radding established the key HR model (Meselson-Radding model) in Scotland! www.pnas.org/doi/full/10....

NR5A2 overexpression improves SCNT efficiency and enhances ZGA by promoting H3K27ac deposition. Great work! journals.plos.org/plosbiology/...

Happy New Year! Check out 👀our new protocol paper on the analysis of transcription factor-nucleosome interactions! Hope you find it useful 🔬🧬Was a pleasure to write up with you @wkobayashi.bsky.social and Kikuë Tachibana!

Happy to share a protocol for analysis of TF-nucleosome interactions and cryo-EM structure determination in STAR Protocols. I had a great opportunity to describe this protocol with @aliciakmichael.bsky.social. Thank you very much, all! www.sciencedirect.com/science/arti...

Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...

Our first cell-free DNA paper is now published! Thank you to all co-authors and collaborators for their contributions.

I'm looking forward to presenting at the Third Scottish Cryo-EM Symposium tomorrow. A nice opportunity to meet cryo-EM folks in Scotland.

This method chapter describes the CUT&Tag approach for profiling transcription factors during murine ZGA. I hope it will be helpful for others studying TF binding profiles in similar contexts. link.springer.com/protocol/10....

I’m pleased to announce that I have now officially started my research group at the University of Dundee, UK. My laboratory focus on how transcription factors orchestrate epigenetic reprogramming in mammalian embryos.

Our study with Anjana Rao's lab was just published at NSMB 🥳 Shows how OGT prevents TET proteins from activating retrotransposons, particularly those in heterochromatin. Paper has 6-base and ONT sequencing data from OGT iKO mESCs, and also interesting OGT inhibitor data 👀. rdcu.be/efuho

Our second cell-free DNA manuscript is here! In collaboration with Dr. Takada’s group, we explore how abemaciclib treatment response in metastatic breast cancer can be monitored via circulating chromatin fragments: www.researchsquare.com/article/rs-5...

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development https://www.biorxiv.org/content/10.1101/2025.02.14.638292v1

🚀Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n) www.biorxiv.org/content/10.1...