How do cells control protein production? This review from the #RNASpecialIssue explores how Ribo-seq and live single-molecule imaging are bringing together genome-wide and real-time views of mRNA translation. Access now: bit.ly/4mjjI8B

Nancy Wexler has spent a lifetime advancing our understanding of Huntington’s disease. In this moving NY Times profile, she reflects on the personal and scientific journey behind her new memoir, "My Life, My Science", published by CSHL Press. Read the article (free access): bit.ly/wexlernytimes

How do researchers make sense of data from millions of individual cells? This review from the #RNASpecialIssue explores how AI and machine learning methods help uncover patterns in single-cell RNA sequencing data, revealing insights into cell identity, function, and disease: bit.ly/4eboUJF

🌟G&D SPOTLIGHT 🌟 G&D is pleased to present a collection of recent articles on RNA biogenesis and regulation. Learn more about small RNA biogenesis, target-mediated miRNA degradation, RNA splicing, ribonucleoprotein granules, and more. ➡️ https://genesdev.cshlp.org/site/misc/collection_rna.xhtml

How can poly(A) site usage be controlled? This review from the #RNASpecialIssue examines strategies to modulate cleavage and polyadenylation sites, highlighting applications in studying alternative polyadenylation and developing new therapeutic approaches. Read more: bit.ly/4sthgOt #RNA #RNABiology

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on allele-specific splicing in Alzheimer's disease, tissue-specific gene regulation by vitamin B, and more! tinyurl.com/Genome-Res-3...

Can we map miRNAs and their targets in brain tissue? Current spatial transcriptomics methods can't simultaneously measure miRNAs and their target 3′UTRs. This review from the #RNASpecialIssue explores the challenge and emerging solutions: bit.ly/4sv5Dq1 #RNABiology #MicroRNA

RNA function is defined by its interactions. This review from the #RNASpecialIssue surveys new methods to map protein–RNA and RNA–RNA contacts, helping reconstruct RNA interaction networks at transcriptome scale. bit.ly/41KDfWl #RNAbiology #Interactome #Genomics

How well can machine learning predict RNA secondary structure? This review in the #RNASpecialIssue examines current approaches—from deep learning to hybrid models—while exploring the field’s “generalization crisis” and the rise of RNA foundation models. bit.ly/4spSj6s

How well do deep learning models generalize in RNA secondary structure prediction? This Perspective from the #RNASpecialIssue explores the “generalization gap” limiting current methods and how AI is reshaping RNA structure prediction. bit.ly/4dx1lec #RNABiology #RNAstructure #Bioinformatics

Nanopore direct RNA sequencing is reshaping epitranscriptomics — enabling direct detection of RNA modifications and RNA damage across entire transcriptomes with long-read sequencing. New review from the #RNASpecialIssue: bit.ly/3POaGo9 #RNA #Epitranscriptomics #Nanopore

What’s next for RNA biology at system scale? In this Special Issue editorial, the editors frame a shift toward quantitative, integrative approaches, highlighting advances in measuring, modeling, and ultimately manipulating RNA across biological systems. bit.ly/41hv9UJ #RNASpecialIssue

We're pleased to feature a recent Special Issue of RNA showcasing advances in system-level RNA biology—from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond. A strong snapshot of where the field is heading. bit.ly/RNAspecialis...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on somatic mutant alleles in bulk tumor samples, honey bee gut microbiota, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on chromosome engineering in 8p syndrome, convergent evolution in arid rodents, and more! tinyurl.com/Genome-Res-3...

Vulnerable to Huntington’s Disease, Nancy Wexler devoted her life to research that revealed the HD mutation and produced a test for susceptibility. Read her powerful autobiography published by CSHL Press: "My Life, My Science: Pursuing a Cure for Huntington’s Disease". Pre-order at: amz.cx/3c1w

A new issue of CSH Protocols is out! @cshlpress.bsky.social The cover image highlights the work by Moss et al., who describe how to use fluorescence flow cytometry and specific AuxInYeast strains to study #maize auxin perception. ⬇️Links below

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on transposable elements in pancreatic cancer, genomic evolution in living fossils, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research the 3D genome organization in breast cancer, assisted reproductive technology mutation rate, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch is now live. Follow the link to new research on wheat centromere adaptation, Quadrupia - a G-quadruplex database, and more! tinyurl.com/Genome-Res-3...

Now Available! “Epigenetics: History, Molecules, and Diseases” cuts through hype to trace the field from its origins to today’s genomic landscape. A clear, authoritative guide to what epigenetics is—and is not. Now in print + eBook formats: bit.ly/epigeneticsb...

Coming Soon: 'Epigenetics: History, Molecules, and Diseases' by John Greally. A clear-eyed, provocative journey through one of biology’s most captivating and misunderstood ideas. Available in print, eBook, and Kindle formats Tuesday, October 21. #Epigenetics #MolecularBiology #CellBiology #Genomics

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on microglia in neurodegenerative diseases, intron retention in nuclear RNA complexes, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on HER2 isoform diversity and drug resistance in breast cancer, off-target site detection in prime editing, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on oxygen stress and gene regulation in the brain, a new C. elegans reference genome, and more! tinyurl.com/Genome-Res-3...

New issue of Genes & Development! Inspired by the 2025 CSHL Symposium on Aging & Senescence, this issue features a collection of Outlook, Perspective, and Review articles on the impact of aging on metabolism, immunity, reproductive health & cancer. Online now: genesdev.cshlp.org/content/39/15-16.toc

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on single-cell multiomics of muscle response to endurance exercise, a method for Nanopore data compression, and more! tinyurl.com/Genome-Res-3...

The new issue of @genomeresearch.bsky.social is now live. Follow the link to new research on TP53 regulation of transposable elements in cancer, gut microbiome–associated protists, and more! tinyurl.com/Genome-Res-3...

Call for Papers! @genomeresearch.bsky.social is now encouraging submissions for a Special Issue on The Genetics and Genomics of Somatic Mosaicism, Guest Edited by Drs. Gilad Evrony, Eunjung (Alice) Lee, and Raheleh Rahbari. tinyurl.com/Call-for-pap... #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

The new issue of Genome Research is now live! Follow the link to a new ultra-long nanopore sequencing toolkit, a unified analysis of atlas single-cell data, and more! tinyurl.com/Genome-Res-3...

📽️ G&D Tapes 📽️ G&D author, Jelani Lyda talks about a new study in #GenesDev by Riley et al. reporting the role of ClpCP protease and novel protein MdfA in driving metabolic differentiation and dormancy during bacterial sporulation. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352535

SF3B1: from core splicing factor to oncogenic driver — this #RNASpecialIssue article explores how SF3B1-mutant splicing drives cancer, with insights into prognosis, phenotypes & the need for targeted therapies. bit.ly/4bqmRy2

RNA-binding proteins at the crossroads of disease: Fragile X & SMA. This #RNASpecialIssue article traces how SMN complex, RNP assembly, and more emerged from curiosity-driven, collaborative RNA research. bit.ly/3Xv2hGX

SPECIAL ISSUE Part 2! This month @genomeresearch.bsky.social publishes a diverse collection of articles offering novel biological and clinical insights gained using long-read DNA and RNA sequencing technologies and other long molecule approaches. tinyurl.com/Genome-Res-3...

Connecting genotype and phenotype in minor spliceosome diseases. This article from the #RNASpecialIssue outlines the current structural and functional knowledge of the minor spliceosome, and discusses emerging challenges in connecting molecular dysfunctions to clinical phenotypes. bit.ly/4bt3aWz

This Perspective from the #RNASpecialIssue summarizes the current knowledge of translation dysregulation in cancer, with emphasis on the eukaryotic translation initiation factor 4F complex. It outlines recent endeavors to develop novel treatment strategies to combat cancer: bit.ly/3F4Sv8g

Adenosine-to-inosine RNA editing by ADARs, first discovered in the 1980s, plays a complex role in disease. This #RNASpecialIssue review explores current knowledge, therapeutic potential, and key unanswered questions. bit.ly/3F3Vqy1

Exploring the therapeutic potential of modulating nonsense-mediated mRNA decay. This paper from the #RNASpecialIssue explores promising approaches employed to regulate NMD for therapeutic purposes, and highlights potential challenges in future clinical development. bit.ly/3F86Ron

This review from the #RNASpecialIssue discusses the distribution, regulation, and mechanisms of cytoplasmic polyadenylation element-binding proteins (CPEBs), highlighting their dual roles in either promoting or repressing gene expression depending on cellular context. bit.ly/41pFqhp

🧬 This National Children's Book Day, meet the tiny heroes inside us all! Stem Cells to the Rescue from CSHL Press is a science adventure that shows kids how our bodies heal. #ChildrensBookDay #STEMforKids #CSHLPress www.cshlpress.com/default.tpl?...

Alternative splicing (AS) is vital for heart function, and its disruption is linked to disease. This #RNASpecialIssue article highlights nonsplicing roles of AS factors and proposes a novel disease mechanism involving pathogenic RNA granules and disrupted AS factor localization. bit.ly/3DkHM9d

Cytoplasmic viruses alter nuclear trafficking, causing RNA-binding proteins (RBPs) to relocate and act as antiviral defenses. This article from the #RNASpecialIssue explores host–virus interactions and the unanswered questions about their mechanisms. bit.ly/3QJOjNG

This article examines how RNA sensors bind ligands and trigger type I interferon-stimulated genes. It also explores how mutations in RNA sensors and RNA homeostasis genes are linked to autoimmune and autoinflammatory diseases. bit.ly/4bowQEb #RNASpecialIssue

Viral quasispecies are dynamic mutant distributions that arise from high RNA replication error rates. This article from the #RNASpecialIssue reviews the molecular basis of mutant swarm formation, its role in viral disease and epidemics, and more: bit.ly/4kovSf0

This article examines RNA gain-of-function mutations from expanded short tandem repeats (STRs) in developmental and degenerative diseases. It discusses STR roles in RNA processing, their impact on myotonic dystrophy, and relevance to other STR expansion disorders: bit.ly/4igE5jS #RNASpecialIssue

🧪Awesome Lizzie from the press office @kingsnmes.bsky.social has written a story about our new papers in Genes & Development @cshlpress.bsky.social which identify MdfA, a new protein that helps bacteria shut down their metabolism as they transform into spores: www.kcl.ac.uk/news/scienti...

Fragile X syndrome (FXS) is caused by CGG repeat expansion in FMR1, leading to DNA methylation and loss of FMRP. This #RNASpecialIssue paper explores how splice-switching ASOs and kinase inhibition can restore FMR1 expression, offering new therapeutic potential: bit.ly/4i2UpF2 #FragileX #RNAsplicing

The new issue of @genomeresearch.bsky.social is now live! Follow the link to new research on mitochondrial–nuclear gene expression regulation, guppy Y Chromosome genomics, and more! tinyurl.com/Genome-Res-3...

YTHDF2, a key m6A reader, regulates the m6A-modified epitranscriptome in development, stem cell expansion, and immune evasion. This #RNASpecialIssue review explores its mechanisms and therapeutic potential in cancer treatment. Read more: bit.ly/4knZut8

Modifications of mitochondrial tRNA (mt-tRNA) are crucial for decoding and stabilizing tRNA. This review from the #RNASpecialIssue examines their roles in disease and emerging therapies. bit.ly/3EYriE3