Excited to share my latest preprint on establishing a generalizable toolkit for decoding the gene regulatory landscape using two types of CRISPR screens. Big thanks to my amazing mentor @nevillesanjana.bsky.social for the in-depth thread below. Looking forward to feedback and comments!

Delighted to share new work from our lab: MultiPerturb-seq 🎛️ ❌ ↕️ Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O