Sydney Miles
@sydneylmiles.bsky.social
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Studying Shigella sonnei pathogenesis and evolution @ LSHTM in the Mostowy Lab 🧬🐟
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Sydney Miles
LSHTM AMR Centre
7 months ago
🔊 Empowering women in science means amplifying voices, breaking barriers, and driving change. Ahead of
#IWD2025
, we celebrate Dr. Sydney Miles, whose career is a testament to perseverance, passion, and the power of representation in science. 🔗
bit.ly/4kwlPVl
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Empowering women in science: Sydney’s journey and impact | LSHTM
Empowering women in science: Sydney’s journey and impact | LSHTM
https://bit.ly/4kwlPVl
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Sydney Miles
MicrobesNG
7 months ago
Incredible
#MicrobialGenomics
research powered by MicrobesNG—highlights from our global community of researchers! 🌍🔬
@sydneylmiles.bsky.social
presents 15 complete epidemiologically relevant Shigella sonnei genomes, including critical pINV invasion plasmid
www.biorxiv.org/content/10.1...
#MicroSky
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A public resource of 15 genomically characterised representative strains of Shigella sonnei
Shigella sonnei is rapidly emerging as the dominant agent of shigellosis, an enteric disease responsible for a significant burden of morbidity and mortality worldwide. Whole-genome sequencing of S. so...
https://www.biorxiv.org/content/10.1101/2025.02.03.635664v1.abstract
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Sydney Miles
VinTorraca
7 months ago
There are still a couple of days to apply for this PhD project. A fantastic KCL-A*STAR partnership to study bacterial persistent infections!
@vintorraca.bsky.social
@oehlerslab.org
Project 4.1 of the project catalogue, page 10 Deadline to apply: 23rd February!
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As promised, part 2 here! 🐟 We found that isolates from the dominant lineage 3 of Shigella sonnei carry fewer genes encoding adhesins and fimbriae, but virulence-associated regions remain highly conserved - pointing towards immune evasion and host restriction
8 months ago
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Sydney Miles
bioRxiv Microbiology
8 months ago
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
https://www.biorxiv.org/content/10.1101/2025.02.05.636615v1
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Most Shigella sonnei experimental work relies on a 70yr old lab strain that doesn’t reflect those circulating today - we are excited to share a (soon to be) publicly available set of genomes and isolates to fill that gap! An exciting part 2 featuring our favourite fish to follow very shortly… 🐟
8 months ago
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Sydney Miles
bioRxiv Microbiology
8 months ago
A public resource of 15 genomically characterised representative strains of Shigella sonnei
https://www.biorxiv.org/content/10.1101/2025.02.03.635664v1
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Sydney Miles
Stefan Oehlers
8 months ago
Got anyone that you would want to banish to rainy London then sweltering Singapore with a risk of giving themselves a shigella infection? Exchange program PhD Project with me and Vincenzo Torraca on page 10
#zebrafish
at
@astar-idlabs.bsky.social
www.kcl.ac.uk/study-legacy...
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Joint A*STAR - King’s College London PhD Studentships in Biomedical Science 2025/26
King's College London is seeking outstanding and motivated students to join our university and the Agency for Science, Technology and Research (A*STAR).
https://www.kcl.ac.uk/study-legacy/funding/joint-astar-kings-college-london-phd-studentships-in-biomedical-science-and-natural-mathematical-science
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Sydney Miles
VinTorraca
8 months ago
Great opportunity for prospective PhD students! Join my lab at KCL and Stefan Oehlers lab at A*STAR to help us dissect how certain bacteria establish infections that are difficult to eradicate in vivo! Project 4.1 of the project catalogue, page 10 Deadline to apply: 23rd February!
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Sydney Miles
Kate Baker
9 months ago
Certain sublineages of antimicrobial resistant bacteria dominate the surveillance landscape, but what causes them to become resistant? Check out our latest work in Shigella to find out and/or read the thread below
www.medrxiv.org/content/10.1101/2024.10.27.24316207v2
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Sydney Miles
Zebrafish Rock!
10 months ago
Woohoo! Congrats, Dr. Miles 🎉
#PhDone
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What better occasion to mark my first Bluesky post than passing my PhD viva?! 🎓 A huge huge thank you to my supervisors
@sergemostowylab.bsky.social
and
@katholt.bsky.social
and of course the examiners
@jayhinton.bsky.social
and Lucy Weinert for making the defense a great experience!
10 months ago
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Sydney Miles
Serge Mostowy
10 months ago
www.nature.com/articles/s41...
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Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions - Nature Reviews Microbiology
In this Review, Scott et al. review our current knowledge of Shigella sonnei, highlighting recent insights into this globally disseminated antimicrobial-resistant pathogen and assessing how novel data...
https://www.nature.com/articles/s41579-024-01126-x
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Sydney Miles
Melanie Blokesch
10 months ago
Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n
www.biorxiv.org/content/10.1...
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Diverse phage defence systems define West African South American pandemic Vibrio cholerae
Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West ...
https://www.biorxiv.org/content/10.1101/2024.11.23.624991v1
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Sydney Miles
Phil Elks
10 months ago
An exciting PhD opportunity in a great collaboration between
@noelresearchlab.bsky.social
and my lab looking at heart infections in zebrafish. Details below. Deadline is the 13th December.
www.findaphd.com/phds/project...
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