Gregor Diensthuber
@gdiensthuber.bsky.social
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PhD student @NovoaLab @CRGenomica |Wet-Lab 🔁 Dry-Lab | RNA modifications | Method Development 🧬⚒
reposted by
Gregor Diensthuber
Cees Dekker
14 days ago
Latest
#CDlab
paper on nanopore protein sequencing on
@biorxivpreprint.bsky.social
:
www.biorxiv.org/cgi/content/...
Here, Justas Ritmejeris,
@xiuqichen.bsky.social
, collaborator
@albadalab.bsky.social
and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
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Awesome place to do a PhD with exciting labs, a truly supportive PhD community, and the most scenic morning views you can imagine! 🌅 10/10
add a skeleton here at some point
about 1 month ago
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reposted by
Gregor Diensthuber
Martin Steinegger 🇺🇦
about 1 month ago
End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐
evedesign.bio
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reposted by
Gregor Diensthuber
Ferriol Calvet
about 2 months ago
Very excited to share our new paper on the influence of biological sex and smoking in the clonal landscape of normal human bladder, just published in Nature. A big thank you and congrats to all the authors, specially to
@raquelbmi.bsky.social
for all the shared efforts in this journey! ⬇️More info⬇️
add a skeleton here at some point
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reposted by
Gregor Diensthuber
Novoa Lab @CRG
about 2 months ago
Novoa Lab joined the PRBB Open Day 2025🔬🧬🌊
@prbb.org
to share our passion for RNA research with the public. Thanks to everyone who came to explore science with us and thanks organisers for making this event possible!
#PRBBOpenDay
#OpenScience
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reposted by
Gregor Diensthuber
TanentzapfLab
4 months ago
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
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reposted by
Gregor Diensthuber
4 months ago
Looks like private funders, HHMI,CZI etc., are not going to “save” US research. Europe is setting up mechanisms to attract US researchers & it may work. But, common, target junior talent, don’t shower money on superstars who will be flying professors & return to US when the science winter passes.
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reposted by
Gregor Diensthuber
Ryan Flynn
4 months ago
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie
@vinnieviruses.bsky.social
and in collaboration with
@vijayrathinam.bsky.social
in
@nature.com
www.nature.com/articles/s41...
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reposted by
Gregor Diensthuber
Javier Santoyo
4 months ago
Systematic benchmarking of basecalling models for RNA modification detection with highly-multiplexed nanopore sequencing.
#DirectRNAsequencing
#DRS
#RNAmodifications
#Nanopore
#Genomics
#Bioinformatics
#ModelBenchmarking
#Basecalling
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
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🚨 New preprint alert 🚨 We systematically benchmarked
@nanoporetech.com
's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
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Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
https://bit.ly/4lXqNul
5 months ago
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reposted by
Gregor Diensthuber
Novoa Lab @CRG
5 months ago
Another epic Novoa Lab retreat in the books! A big thank you to everyone who made it such a success — from the science-packed discussions and hands-on workshops to the brainstorming, games, sunny pool sessions, and delicious BBQs. And special thanks to the organizers!⚘️
@evamarianovoa.bsky.social
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reposted by
Gregor Diensthuber
Cell - a Cell Press journal
5 months ago
Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
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Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds that poor nuclease processing and selective TLR avoidance drive this evasion, offering insight into the molecular basis of immune tolerance to pseudouridine-containing RNA.
http://dlvr.it/TLbY2b
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reposted by
Gregor Diensthuber
Centre de Regulació Genòmica (CRG)
6 months ago
Endinsa’t en una vivència sensorial única que connecta ciència i art immersiu. “SEEING: Un ull i una caixa” arriba del 5 al 14 de juny al Centre Cívic Convent de Sant Agustí (Carrer del Comerç 36, Barcelona).
www.crg.eu/en/event/see...
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reposted by
Gregor Diensthuber
Sebastiaan van Heesch
7 months ago
### PhD position alert ### Please repost! I'm excited to announce a new *PhD position* within our group. We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!
werkenbijprinsesmaximacentrum.nl/en/vacancy/p...
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PhD Position: Unraveling the Dark Proteome in Pediatric Cancer - Werken bij Prinses Maxima Centrum
Background For decades, vast stretches of the genome were dismissed as non-functional ‘junk’. However, our group and others have revealed that these regions harbor numerous non-canonical open reading ...
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/phd-position-unraveling-the-dark-proteome-in-pediatric-cancer/
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reposted by
Gregor Diensthuber
Carolyn Bertozzi
7 months ago
Check it out - amazing new work by
@raflynn5.bsky.social
and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy!
www.nature.com/articles/s41...
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Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
An RNA-binding protein on leukemia cells provides an effective target in mouse models.
https://www.nature.com/articles/s41587-025-02648-2
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reposted by
Gregor Diensthuber
Böke Lab
10 months ago
This was a fun interview by
#FelixSchmidtner
of Austrian
@derstandard.at
- EB
www.derstandard.at/story/300000...
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Was Eizellen zu einem Wunder der Natur macht
Eizellen können mehrere Jahrzehnte alt werden und verfügen auch sonst über Tricks, die sie von allen anderen Zellen im Körper abheben. Vieles bleibt dennoch unverstanden
https://www.derstandard.at/story/3000000250162/was-eizellen-zu-einem-wunder-der-natur-macht
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How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by
@evamarianovoa.bsky.social
and I now live in Molecular Cell
#RNAsky
#RNA
#nanopore
authors.elsevier.com/a/1kS2f3vVUP...
10 months ago
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reposted by
Gregor Diensthuber
Frances Yap
12 months ago
rRNA fingerprinting by Nanopore sequencing reveals cell type biosignatures. 🧪
#RNASky
www.cell.com/molecular-ce...
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Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures
Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.
https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00919-5
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Elegant work from the labmate
#IvanMilenkovic
showing that 'epitranscriptomic fingerprints' of highly modified rRNAs can classify tissues / dev. stages / cell types and even health/disease status!
#notstatic
www.cell.com/molecular-ce...
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Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures
Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints,” are sufficient to accurately identify tissue of origin and tumorigenicity, from as few as 250 reads.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00919-5
12 months ago
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reposted by
Gregor Diensthuber
David Eccles 🌻🇵🇸7x🩹🛡️
about 1 year ago
New paper from Eva Maria Novoa's lab, demonstrating how barcoded direct RNA reads can be demultiplexed on
#nanopore
github.com/novoalab/Seq...
www.biorxiv.org/content/10.1...
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SeqTagger, a rapid and accurate tool to demultiplex direct RNA nanopore sequencing datasets
Nanopore direct RNA sequencing (DRS) enables direct measurement of RNA molecules, including their native RNA modifications, without prior conversion to cDNA. However, commercial methods for molecular ...
https://www.biorxiv.org/content/10.1101/2024.10.29.620808v1
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