Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Now published! Phosphorylation patterns modulate transient secondary structures of the intrinsically disordered CTD of RNA polymerase II www.sciencedirect.com/science/arti...

ICYMI: New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch

Open position in @ceesdekker.bsky.social lab! Apply if you are interested in nanopore sequencing!

Come join us!

Building a synthetic cell together - nice common perspective written by many leading scientists who gathered in Shenzhen China for the inaugural ‘SynCell Global Summit’. Check it out in Nature Comm: www.nature.com/articles/s41...

🏖️Back from an amazing vacation in 🌴Sanya🐟. Refreshed and recharged, ready to dive back to research!

Telomeres stall DNA loop extrusion by condensin

🤔 How do proteins fold while they're still being made? As the main project in my PhD, I developed "Arrest Peptide Profiling" to record proteins folding with as they emerge from ribosomes in living cells 🦠 - with single codon resolution! @natcomms.nature.com‬ 🧵 1/6 #ProteinFolding

Really appreciate your support on this project @ceesdekker.bsky.social ! Excited to make new discoveries!

New online: Q&A with Francesca Mattiroli

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

Here's a new very exciting paper from our #CDlab: www.cell.com/cell-reports... In an exemplary in vitro/in vivo study, 1st authors ‪@btanalikwu.bsky.social‬ & Alice Deshayes showed that dense linear protein arrays (e.g. telomeres) do stop loop-extruding SMCs! Great collaboration with Marcand lab.

The energy landscape of a single disordered protein (tau) and the impact of PTMs is resolved. An important step to understanding the function and dysfunction of disordered proteins from their conformational ensemble. Not yet peer reviewed. www.biorxiv.org/content/10.1...

“Research assistants, local collaborators & community partners, esp those from the Global South, are often seen as data collectors rather than co-creators of knowledge” A great piece on inclusive authorship & the need for flexibility @lseimpactblog.bsky.social blogs.lse.ac.uk/impactofsoci...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Preprint on hifiasm Nanopore-only assembly. Led by Haoyu Cheng: www.biorxiv.org/content/10.1...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

MINFLUX works well in theory, but system and sample imperfections can lead to suboptimal resolution. To address this, @jonasries.bsky.social and I developed SimuFLUX: www.biorxiv.org/content/10.1..., a realistic simulator to optimize MINFLUX experiments before samples go on the microscope.

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

A horse’s gallop was once a blur—until film revealed its rhythm. Sonja Schmid (@scisonja.bsky.social) draws a parallel to biomolecules: only by observing them one at a time can we understand their dynamics. Her team is developing a method using nanopores that let single molecules pass through.

If you're critical of the US government and you are planning to cross the US border any time soon, today is a good day to review EFF's border search pocket guide: www.eff.org/document/eff...

Out now! Our latest paper where we show a "one-pot" labelling technique which allows for simultaneous mechanical and fluorescent readouts from a protein (Hsp90): onlinelibrary.wiley.com/doi/10.1002/... Congratulations to everyone who worked on this, especially Laura!

We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes. Check it out and apply: ceesdekkerlab.nl/come-join-us/ RT=nice!

I regret to announce that the meme Turing Test has been passed LLMs produce funnier memes than the average human, as judged by humans. Humans working with AI get no boost (a finding that is coming up often in AI-creativity work) The best human memers still beat AI, however. arxiv.org/abs/2501.11433

A PhD position is open for this year. A candidate should have a background in programming skills.

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

Time to leave Bolzano, and I do that with a sense of great admiration for the field of single molecule protein sequencing #SMPS2025. A superfast moving field, and I’m asked looking forward to the next edition in Thailand. Hopefully I can present our contributions then as well!

Great #SMPS4 conference dinner last night. Very last minute, we organized an impromptu band (@xiuqichen.bsky.social AmitMeller, JavierAlfaro, me) and rented musical instruments to play -as requested by the organizers- some tango music, where conference participants were invited to dance.

Our editor, Raghav Palankar @palankar.bsky.social, is at the Single Molecule Protein Sequencing 2025, Bolzano, IT. www.smps2025.com/program Raghav will be happy to discuss all things single-molecule and nano or chat over a coffee about what professional editors do at scientific journals. #SMPS4

Over the moon at #SMPS4 in Bolzano. Photographer @jritmejeris.bsky.social

Follow by Chirlmin Joo: Decoding protein-peptide interactions with a sequencing platform #SMPS4

Sonja Schmid from University of Basel talking about: Nanopore trapping for protein identification & beyond #SMPS4

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

Day-1 workshop started #SMPS4

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

What a way to start 2025! Our review on the Known Unknowns of the Hsp90 Chaperone has been published! Huge thanks to Laura Silbermann and Benjamin Vermeer for all of their efforts, and to @scisonja.bsky.social for the great collaboration :) You can read it here: elifesciences.org/articles/102...

Today, we report a new discovery about this - a new twist to the story! These SMC motor proteins do not only extrude the DNA into a loop. While doing so, they also put TWIST into the extruded DNA loop! See our paper today in Science Advances: www.science.org/doi/10.1126/... 1/

🚨 ANOTHER JOB OPENING 🚨 We are looking for a Chief Editor for a new @natureportfolio.bsky.social journal launching in 2026: Nature Sensors 🧪 📍 Berlin or New York 🗓️ Closing date: Jan 05, 2025 🙏 Re-posts very much appreciated! springernature.wd3.myworkdayjobs.com/SpringerNatu... #Chemsky

Pod5Viewer: a GUI for inspecting raw nanopore sequencing data. #Nanopore #SequencingData #Bioinformatics #Genomics @nanoporetech.com 🧬 🖥️ academic.oup.com/bioinformati...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

Reply below if you want to be included in the #nanopore starter pack! go.bsky.app/VCoo6T