Melissa Klingeberg
@melissaklingeberg.bsky.social
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spatial and single cell proteomics PhD student at Coscia lab, MDC Berlin
reposted by
Melissa Klingeberg
PastelBio
about 2 months ago
Pho-Tip: one-pot dephosphorylation for rapid and sensitive analysis of DIA phosphoproteomics data
www.biorxiv.org/cont...
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#proteomics
#prot-preprint
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reposted by
Melissa Klingeberg
Coscia Lab
10 months ago
Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions! We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
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Deep spatial proteomics of ovarian cancer precursor lesions delineates early disease changes and cell-of-origin signatures
High-grade serous ovarian cancer (HGSOC) is a devastating disease that is frequently detected at an advanced and incurable stage. Advances in ultrasensitive mass spectrometry-based spatial proteomics ...
https://www.biorxiv.org/content/10.1101/2025.03.19.643504v1
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reposted by
Melissa Klingeberg
Vadim Demichev
10 months ago
Our News & Views on the recent advances in high-coverage single-cell proteomics (on Orbitrap Astral)
www.nature.com/articles/s41...
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Entering the era of deep single-cell proteomics - Nature Methods
Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.
https://www.nature.com/articles/s41592-025-02620-7
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