An interesting new study, by Clare Smith’s lab and me, here at Duke. We found that during Mtb infection, CCR6 knockout mice (on a B6 background) form necrotic pulmonary granulomas, have increased IL17 production and have sex specific differences in susceptibility. journals.asm.org/doi/10.1128/...

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1

#OTD in 1964, Yvonne Barr co-discovered the Epstein-Barr virus, the first known 𝘩𝘶𝘮𝘢𝘯 tumor virus. She cultured the cell lines that allowed the virus be seen. Proving viruses cause human cancer is "one of the 20th century's most significant scientific discoveries." #WomenInSTEM #WomensHistoryMonth

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

New research from Duke University School of Medicine and UNC‑Chapel Hill shows how TB bacteria survive inside granulomas by activating stress‑response genes. The findings offer new insight into long‑term infection. 🔗 Read more: https://medschool.duke.edu/news/genes-help-tb-survive #MedSky

In this World View article, Ruslan Medzhitov discusses the perils of too much data and not enough theory in modern immunology rdcu.be/e2DCZ

Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!! Fantastic team effort ✨ #Tbsky #microsky

#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR http://dlvr.it/TQjZ0W

Given the weather today, it’s time to repost my favorite phase diagram: Nakaya’s snow crystal morphology. We are towards the bottom right today. 🧪 ⚛️ #cryoEM

Excited to share work led by the wonderful Gopi Viswanathan examining roles of granuloma neutrophils &defining bacterial transcriptional profiles within mycobacterial granulomas. Cool collab with Qingyun Liu at UNC for evolutionary analysis of granuloma-specific genes www.science.org/doi/10.1126/...

Human rights activist Rigoberta Menchú was born #OTD in 1959. She has dedicated her life to publicizing the rights of #Guatemala's Indigenous peoples & to promoting Indigenous rights globally. Deservingly, she was awarded the #Nobel Peace Prize in 1992 & is a UNESCO Goodwill Ambassador.

In a new study from Mbano, Liu, Leslie et al., single-cell and spatial transcriptomics of human #TB lung tissues from individuals in South Africa revealed that MMP1⁺CXCL5⁺ #fibroblasts & SPP1⁺ #macrophages are linked to TB disease & TB lung #granuloma rupress.org/jem/article/... #InfectiousDisease

Conversations are a key tool for reimagining the world we want together, and curious exploration can make those conversations successful even when people don't agree

Published version up at @natcomms.nature.com New data with Aspergillus getting into tuberculous granulomas and growing like it's a member of the extended Myco family doi.org/10.1038/s414...

Interested in Zebrafish brain imaging? We released a 3D printed mold that's is super helpful for us. Check it out Customizable FDM-based zebrafish embryo mold for live imaging www.biorxiv.org/content/10.1... Work by Marcela and Jaakko in the lab

A new study led by Harvard Chan School and @busph.bsky.social projects that U.S. funding cuts to global health aid will have a catastrophic effect on pediatric #tuberculosis.

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis. buff.ly/YOkDI4a

Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

New Element in the Philosophy of Biology series—free to download until October 6! Walter Veit examines the role of models in evolutionary biology: their types, testability, and interrelations 👇📕 www.cambridge.org/core/element... #philsci #HPBio #evobio

Really interesting work from our neighbor Clare Smith @dukemedschool.bsky.social starting from CC mice and linking Ctsz to TB infection outcome as well as functional variation in human populations (UW, Case Western, Uganda) and expression in human granulomas (@charliejpyle.bsky.social)

Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection. www.youtube.com/watch?v=VWCt...

You can now explore the mRNA expression of your favorite TB gene of interest in our recently published human pulmonary M.tb granuloma single-cell dataset at the Broad Single Cell PORTAL! @broadinstitute.org @wallacewly.bsky.social singlecell.broadinstitute.org/single_cell/...

Proud to present our latest work! @tobinlab.bsky.social @wallacewly.bsky.social @gregorylab.bskyverified.social Human TB granuloma transcriptional blueprints show they are dominated by SPP1 macrophages. spp1 is essential for granuloma formation in zebrafish. journals.asm.org/doi/10.1128/...

Symptomatic primary EBV infection generates B cell subsets that gain access to the CNS, attract T cells and thereby initiate multiple sclerosis @nature.com www.nature.com/articles/s41...

A review emphasizes the advantages of using zebrafish in research, outlines key differences in experimental approaches, and offers guidelines for designing studies in a way that enhances experimental rigor and reproducibility. www.nature.com/articles/s42...

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

When a person is diagnosed with #tuberculosis, one of their first questions is often, “Why did I get tuberculosis? Why me?” 💬 Explore a Seminar which aims to help healthcare providers identify those at risk of TB & address patient concerns: tinyurl.com/zb2bwces #MedSky

Researchers pinpoint the genes responsible for the final three pea traits studied by Gregor Mendel more than 160 years ago https://go.nature.com/3EC3eqT

Today is a great day to highlight what an incredible, extensive, and diverse learning resource MIT OpenCourseWare is! 🧪 #AcademicSky 🔗 ocw.mit.edu

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

Inspiring speakers highlighting the importance to our collective health as well as economic return on investment of basic, curiosity-driven research at yesterday’s @standupforscience.bsky.social Frightening to see active dismantling of decades of public investments in our health and futures.

Nancy By Ernie Bushmiller February 26,1954

Different flavors of #zebrafish. Credit to Renee Daigle & @margaritapk.bsky.social. #ZebrafishZunday 🧪

Potent & very personal insights from my graduate school mentor Larry Schlesinger on the absurdity of "taking a break" from infectious disease research to focus on chronic diseases. www.statnews.com/2024/12/16/c...

The US public health infrastructure was instituted as a mechanism to control TB, & it worked! Now in a time when the public goods of science and health services are under corporate raid we have a rash of TB outbreaks, this one in my local community. www.independent.co.uk/news/health/...

Public health is the responsibility of the government www.cjonline.com/story/news/p...

Designer Jeans by Tobin218