In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!

Type 2 immunity is thought of as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective. Could it be harness to reimagine cancer immunotherapies? 🧪 @nature.com @natureportfolio.bsky.social www.nature.com/articles/s41...

Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different... #Immunosky #Immunology www.science.org/doi/epdf/10....

Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

A very entertaining paper to run a lab paper discussion group on! academic.oup.com/mbe/article/...

A cell photographed through a microscope. DNA in the nucleus (cyan), the powerhouses/overlords of the cell, mitochondria (yellow), and actin filaments (magenta) are shown. #Science #Biology #CellBiology #microscopy

Nice summary of the cool paper by @poholeklab.bsky.social's lab on IL-2 microniches in Th2 cell differentiation #ImmunoSky